Abstract | PURPOSE OF REVIEW:
Lipoproteins play a critical role in the development of atherosclerosis, which might result partly from their capacity to induce specific intracellular signaling pathways. The goal of this review is to summarize the signaling properties of lipoproteins, in particular, their capacity to induce activation of mitogen-activated protein kinase pathways and the resulting modulation of cellular responses in blood vessel cells. RECENT FINDINGS: SUMMARY: The main blood vessel cell types have the capacity to activate protein kinase pathways in the presence of lipoproteins. This induces cell proliferation, hyperplasia and migration, known to be dysregulated in atherosclerotic lesions.
|
Authors | Iveta Dobreva, Gérard Waeber, Christian Widmann |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 17
Issue 2
Pg. 110-21
(Apr 2006)
ISSN: 0957-9672 [Print] England |
PMID | 16531746
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- Lipoproteins
- Mitogen-Activated Protein Kinases
|
Topics |
- Animals
- Atherosclerosis
(metabolism)
- Humans
- Lipoproteins
(metabolism)
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinases
(metabolism)
|