Abstract | OBJECTIVES: DESIGN AND METHODS: RESULTS:
TBARS concentrations were significantly increased, while erythrocyte GPX and SOD activities were significantly decreased in the prostate cancer group versus controls (P < 0.001) and BPH group (P < 0.05). Zn levels were lowered in prostate cancer patients versus controls (P < 0.01) with no significant changes between BPH and cancer groups. Similarly, lipid peroxidation was increased (P < 0.05) with decreased SOD activity and Zn level (P < 0.05) in BPH versus controls. CONCLUSION: These results reveal an alteration in the lipid peroxidation index, with concomitant changes in the antioxidant defense system in prostate cancer patients compared to BPH patients. We hypothesize that an altered prooxidant- antioxidant balance may lead to an increase in oxidative damage and consequently may play an important role in prostate carcinogenesis.
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Authors | Ahmet Aydin, Zorica Arsova-Sarafinovska, Ahmet Sayal, Ayse Eken, Onur Erdem, Koray Erten, Yaşar Ozgök, Aleksandar Dimovski |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 39
Issue 2
Pg. 176-9
(Feb 2006)
ISSN: 0009-9120 [Print] United States |
PMID | 16413012
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Thiobarbituric Acid Reactive Substances
- Copper
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Zinc
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Topics |
- Aged
- Aged, 80 and over
- Antioxidants
(metabolism)
- Catalase
(blood)
- Copper
(metabolism)
- Erythrocytes
(metabolism)
- Glutathione Peroxidase
(blood)
- Humans
- Lipid Peroxidation
- Male
- Middle Aged
- Oxidative Stress
- Prostatic Hyperplasia
(blood)
- Prostatic Neoplasms
(blood)
- Superoxide Dismutase
(blood)
- Thiobarbituric Acid Reactive Substances
(metabolism)
- Zinc
(metabolism)
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