Abstract | BACKGROUND:
Nephrolithiasis is a common, high costing pathology of the urinary tract. The most common urinary abnormalities are fasting hypercalciuria, hypercalciuria and hypocitraturia. This study aimed to identify the principal urinary abnormalities in our patients. METHODS: Ninety-eight patients (pts) (43 females, 55 males) with recurrent calcium nephrolithiasis underwent metabolic evaluation. In two 24-hr urine collections the following parameters were evaluated: calcium, phosphate, sodium, potassium, chloride, magnesium, citrate, oxalate, uric acid, creatinine (Cr), urea, ammonium and pH; blood measurement of calcium, phosphate, sodium, potassium, chloride, magnesium, uric acid, Cr, urea, acid-base balance ionized calcium and intact parathyroid hormone (iPTH) were also performed. A first morning voided urine sample was collected for measuring the urinary cross-links and fasting calciuria. The tubular threshold of phosphate ( TmP) was calculated according to Walton and Bijovet. Metabolic evaluation was repeated in 63/98 pts after 7 days on a low calcium diet. RESULTS: CONCLUSIONS: Fasting hypercalciuria was the most frequent urinary abnormality and it was not corrected with a calcium-restricted diet. In fasting hypercalciuric patients, increased bone resorption activity could be responsible for higher citraturia levels.
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Authors | Beatrice Damasio, Fabio Massarino, Felice Durand, Riccardo Banchero, Paolo Bottino, Vincenzina De Franchis, Giorgio Carmignani, Giuseppe Cannella |
Journal | Journal of nephrology
(J Nephrol)
2005 May-Jun
Vol. 18
Issue 3
Pg. 262-6
ISSN: 1121-8428 [Print] Italy |
PMID | 16013013
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Calcium, Dietary
- Citrates
- Calcium
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Topics |
- Calcium
(urine)
- Calcium, Dietary
(administration & dosage)
- Citrates
(urine)
- Dose-Response Relationship, Drug
- Fasting
(urine)
- Female
- Follow-Up Studies
- Humans
- Kidney Calculi
(diet therapy, epidemiology, urine)
- Male
- Middle Aged
- Monitoring, Ambulatory
- Outpatients
- Prevalence
- Recurrence
- Retrospective Studies
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