Thymidine Monophosphate (TMP)

03/01/2001 - "Although not optimal treatment, administration of TMP-SMZ is effective against chlamydial infection. "
06/01/1997 - "Intermittent low-dose TMP-SMZ seemed very effective for the prevention of recurrent urinary infection in children with ureteral reflux even of higher grades."
12/01/1996 - "However, they showed marked improvement following TMP-SMZ therapy, which was started for methicillin-resistant Staphylococcus aureus (MRSA) infection. "
03/01/1993 - "It is concluded that SMM-TMP administered orally once a day at 20 mg and 4 mg kg-1 bodyweight, respectively, maintains therapeutic concentrations, whereas twice daily intramuscular administration would be more effective for treating systemic infections in the horse than the once a day regimen usually adopted in veterinary practice."
02/01/2009 - "This case suggests that the combination of VCM, RFP, and SMZ/TMP may be effective for the treatment of severe MRSA infections."

01/01/2000 - "These findings reconfirm the efficacy of TMP-SMZ in preventing community-acquired pneumonia. "
09/01/1992 - "carinii pneumonia were much improved in the group of combination therapy of TMP-SMZ with IFN-gamma. "
01/01/1984 - "Five patients with Nocardia pneumonia were treated with TMP-SMZ and all were cured. "
04/01/1995 - "carinii pneumonia while receiving TMP-SMZ. "
07/01/1994 - "carinii pneumonia but was better tolerated than TMP-SMZ."

01/01/1984 - "Best results (lesser percentage of failures and lesser number of urinary tract infection cases per month of observation) were achieved in the second and third groups, probably due to a high percentage of resistance cases against TMP-SMZ found during prophylactic treatment (72.07)."
03/01/1982 - "TMP alone also was effective in urinary prophylaxis; only three of 39 children experienced a recurrence of urinary tract infection during a total of 309 months of prophylaxis in 1978-1980. "
03/01/1982 - "With the exception of one study in which use of TMP singly for 28 days for treatment of recurrent urinary tract infections selected resistant nonfermenting bacteria, the use of TMP singly for treatment of urinary tract infections has not resulted in selection of resistant Enterobacteriaceae. "
02/01/1979 - "The authors study "in vitro" effects of sulfamethoxazol-trimethroprime (SMZ-TMP) on 1 078 bacterial strains isolated from urinary-tract infections during january 1974, the second trimester 1974 and january 1975. "
12/01/1985 - "Most isolates were from urinary tract infections and showed high-level resistance (minimal inhibitory concentration of TMP greater than 1,000 micrograms/ml). "

01/01/1989 - "It is concluded that for most patients with AIDS and PCP, treatment and secondary prophylaxis with TMP-SMZ is safe and effective."
07/01/1998 - "TMP-SMZ seems to be an efficient therapy for TE in AIDS patients, although further prospective, randomized therapeutic trials are required to confirm these results."
05/01/1992 - "At the end of the study period, 43 TMP were in CDC stage II, 23 in CDC stage III and 13 in CDC stage IV, including seven AIDS cases, of whom three had died. "
09/01/2003 - "HIV/AIDS was not an independent risk factor for TMP-SMZ nonsusceptibility. "
09/01/2003 - "Certain serotypes (serotypes 6A, 6B, 9N, 9V, 18C, 19A, 19F, and 23F) were more common among patients with HIV/AIDS than in adults with no underlying disease (P<.05, vs. serotype 4), even when TMP-SMZ-nonsusceptible isolates were excluded. "

12/01/2002 - "The authors' proposed threshold value for assigning positive results for TMP and SMX hypersensitivities was 22.5%. "
01/01/1992 - "Prophylaxis was very well tolerated; none of the 66 recipients of TMP-SMZ, who took the drug for an average of 8.9 months, was withdrawn from the study because of hypersensitivity or toxic side effects. "
01/01/1993 - "Five out of 31 (16%) patients developed hypersensitivity to TMP, and two ceased TMP as a result. "
08/01/1992 - "In our patients skin prick tests with TMP were useful in TMP hypersensitivity diagnosis."
03/01/1991 - "Initially described in patients treated with SMX-TMP for PCP, allergy is now known to involve a multitude of drugs. "