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Bone Resorption

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Bone loss due to osteoclastic activity.

Also Known As:

Bone Losses, Osteoclastic; Bone Resorptions; Loss, Osteoclastic Bone; Losses, Osteoclastic Bone; Osteoclastic Bone Losses; Resorption, Bone; Resorptions, Bone; Bone Loss, Osteoclastic; Osteoclastic Bone Loss

Networked: 12154 relevant articles (385 outcomes, 1266 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteoporosis
2.	Neoplasm Metastasis (Metastasis)
3.	Neoplasms (Cancer)
4.	Hypercalcemia (Milk Alkali Syndrome)
5.	Pain (Aches)

Experts

1.	Iwamoto, Jun: 40 articles (01/2013 - 01/2002)
2.	Delmas, P D: 31 articles (09/2008 - 01/2000)
3.	Garnero, P: 28 articles (02/2011 - 02/2000)
4.	Sato, Yoshihiro: 27 articles (01/2013 - 01/2004)
5.	Zaidi, Mone: 26 articles (07/2013 - 09/2002)
6.	Takeda, Tsuyoshi: 26 articles (09/2012 - 01/2002)
7.	Väänänen, H Kalervo: 25 articles (09/2015 - 01/2002)
8.	Terpos, Evangelos: 25 articles (01/2015 - 01/2003)
9.	Kim, Hong-Hee: 23 articles (12/2015 - 04/2004)
10.	Lewiecki, E Michael: 23 articles (04/2015 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bone Resorption:

1.	DiphosphonatesIBA 07/01/2012 - "The antireabsorptive action of bisphosphonates has been considered the most effective in the disorders characterized by an excessive bone resorption. " 01/01/2005 - "Bisphosphonates are proven to be effective in the treatment of benign or malignant skeletal diseases characterized by enhanced osteoclastic bone resorption. " 01/01/2004 - "Bisphosphonates have been used effectively in adults and children to treat other bone disorders, since they have been proven to increase bone density through inhibition of bone resorption. " 09/01/1998 - "Bisphosphonates (BPs) are potent inhibitors of bone resorption and are therapeutically effective in disease of increased bone turnover, but their mechanism(s) of action remain to be elucidated. " 10/01/1993 - "The general availability of an ever-expanding range of increasingly potent bisphosphonates has resulted in a dramatic improvement in the treatment of increased bone resorption associated with malignancy. "
2.	CalciumIBA 11/01/2002 - "Adding three servings of yogurt to the daily diet of older women with habitually low calcium intakes resulted in a significant reduction in urinary excretion of N-telepeptide, a marker for bone resorption. " 05/01/1982 - "After short-term therapy (6-8 months), calcium absorption was normal (27 +/- 3%, P less than 0.001 for difference from base line), calcium balance had improved (+2 +/- 26 mg/day, P less than 0.05), and bone resorption rate (195 +/- 35 mg/day, P less than 0.01) had decreased more than bone formation rate (197 +/- 26 mg/day, NS). " 06/01/1991 - "There was evidence of an immediate reduction in bone resorption, with increased calcium absorption (delayed in Patient 1), improved calcium balance and maintained or improved bone density indices in the axial and peripheral skeleton. " 01/01/2015 - "This study showed that a calcium-rich pre-exercise breakfast meal containing ~1350 mg of calcium consumed ~90 min before a prolonged and high intensity bout of stationary cycling attenuates the exercise induced rise in markers of bone resorption--PTH and CTX-I. Australian New Zealand Clinical Trials Registry ACTRN12614000675628." 06/01/2012 - "The aim of the present study was to assess whether a dipeptidylpeptidase (DPP)-4 inhibitor affects markers of bone resorption and calcium homeostasis. "
3.	Alendronate (Alendronate Sodium)FDA LinkGeneric 09/01/2010 - "This prospective study, in the very early phase after initiation of glucocorticoid (GC) treatment, showed that alendronate was effective in suppressing accelerated bone resorption and subsequent decrease in bone mineral density (BMD) at the lumbar spine of patients with high-dose GC treatment. " 10/01/2010 - "After 3 months of alendronate, there was no significant reduction in the number of osteoclast precursors, osteoclast formation and viability, and cytokine levels, whereas, there was a significant reduction of bone resorption markers. " 09/01/2010 - "Alendronate was effective in suppressing bone resorption and subsequent BMD decrease at the lumbar spine in patients with high-dose GC treatment." 05/01/2000 - "The present study was designed to examine histopathologically whether local delivery of aminobisphosphonate (alendronate) could be effective in preventing the alveolar bone resorption associated with mucoperiosteal flaps. " 01/01/2001 - "Alendronate sodium (Fosamax) is a commonly used antiresorptive agent effective in osteopenic women for reducing bone resorption, increasing bone density, and decreasing fracture incidence. "
4.	pamidronate (APD)FDA LinkGeneric 10/01/1989 - "Dimethyl-APD therapy was highly effective in inhibiting bone resorption. " 01/01/1989 - "Dichloromethylene bisphosphonate and aminobisphosphonate, especially APD, were shown to inhibit bone resorption with no noticeable inhibition of bone formation, and were highly effective in the long-term treatment of Paget's disease. " 04/01/2002 - "This report describes a case of refractory HPOA with complete remission following the administration of IV pamidronate, which is a potent inhibitor of osteoclastic bone resorption. " 08/01/1988 - "Due to the important and sustained inhibition of bone resorption induced by AHPrBP, a single infusion of 60 mg of the bisphosphonate leads to a rapid decline in activity and a long-standing remission of moderate Paget's disease, without significant side effects." 01/01/1997 - "Pamidronate seems to be more effective in inhibiting bone resorption in bone that undergoes rapid turnover (i.e. "
5.	Biological Markers (Surrogate Marker)IBA 05/01/2008 - "Since the anti-fracture efficacy of inhibitors of bone resorption or stimulators of bone formation appears to be largely independent of baseline bone turnover, biochemical markers do not appear to play a significant role in the selection of one particular drug, for an individual patient. " 10/01/2001 - "Treatment with SB-357114 (12 mg/kg subcutaneously) resulted in a significant reduction in serum markers of bone resorption relative to untreated controls. " 04/16/1997 - "Efficacy of both the treatment can be assessed after 6 months using a biochemical marker of bone resorption and after 2 years using dual-energy x-ray densitometry." 09/01/2015 - "The purpose of this study was to investigate the use of saliva as a medium for the identification of biomarkers associated with bone resorption and formation. " 12/01/2014 - "This study investigated breast milk and maternal serum concentrations of biochemical markers of bone resorption, which may be implicated in both maternal and neonatal bone metabolism. "
6.	deoxypyridinolineIBA 05/01/2008 - "Furthermore, markers of osteoclastic bone resorption, including osteoclast number, osteoclast surface, and urinary deoxypyridinoline excretion, were again significantly greater only in the triply NOS(-/-) mice. " 02/01/2002 - "Urinary deoxypyridinoline, an index of bone resorption, was significantly greater in TS rats, but unaltered by (-)Cu. " 01/01/2009 - "Deoxypyridinoline (DPD) is a derivative of hydroxypyridinium, which is released during bone resorption into the blood stream and is eliminated unmodified with urine. " 10/01/1994 - "We now describe the development of an immunoassay (ELISA) based on a monoclonal antibody for free deoxypyridinoline (Dpd) and its use in healthy individuals and patients with bone-related disorders to measure the urinary excretion of Dpd as an improved assessment of bone resorption rate. " 09/01/2008 - "Femur bone density decreased, and urinary excretion of deoxypyridinoline, an index of bone resorption capacity of osteoclasts, increased in ovariectomized animals at the end of the study. "
7.	Vitamin D FDA LinkGeneric 09/01/2003 - "These material properties, together with indications of decreased bone resorption in secondary spongiosa and increased cortical periosteal bone formation, appear to contribute to the improved mechanical properties of their long bones and suggest an important physiological role of the vitamin D-endocrine system in normal bone mineralization." 04/01/1997 - "Also the vitamin D-supplemented animals exhibited significantly greater levels of bone resorption. " 03/01/2014 - "The vitamin D treatment is accompanied by reduced bone resorption and improved bone mineral density before operation." 01/01/2014 - "Several studies have been performed to elucidate the mechanism by which active vitamin D compounds suppress bone resorption in vivo. " 11/01/2008 - "Studies in hypercalciuric TRPV5 knockout (TRPV5(-/-)) mice, which display significantly increased vitamin D levels, showed that TRPV5 ablation increases number and size of osteoclasts but impairs osteoclast-mediated bone resorption. "
8.	Estrogens (Estrogen)FDA Link 12/01/2012 - "Oral doses of BSSF in the preclinical setting are effective in preventing estrogen deficiency-induced bone loss by dual action: inhibition of bone resorption and stimulation of new bone formation." 01/01/2003 - "Estrogen has protective effects on the skeleton via its inhibition of bone resorption. " 07/01/2010 - "Our cell-based and mouse genetic studies have shown that FSH stimulates bone resorption by osteoclasts directly in a pituitary-bone axis, independently of the estrogen effect. " 01/01/2005 - "It has been shown in recent animal studies that increased B lymphopoiesis induced by estrogen deficiency is involved in the mechanism of stimulated bone resorption. " 04/01/2002 - "Recent studies have shown that estrogen (E) likely plays a dominant role in inhibiting bone resorption in normal elderly men. "
9.	risedronic acid (risedronate)FDA LinkGeneric 02/01/2012 - "We previously reported that risedronate improved the structural parameters of the proximal femur, as well as lumbar spine and proximal femoral bone mineral density (BMD), after 1 year of therapy by suppressing bone resorption in patients with an increased risk of fracture. " 01/01/2007 - "At the spine, however, this correlation exists down to a 40% fall in bone resorption markers; larger drops did not provide further protection against fractures in patients taking risedronate in one evaluation of this relationship. " 09/01/2014 - "Under the metabolic profile, these studies have also shown that risedronate activity can reduce bone resorption markers and increase bone density values at lumbar and femoral level. " 12/01/2001 - "In the clinical trials reviewed here, antiresorptive therapy using the bisphosphonate, risedronate, significantly reduced the incidence of vertebral and nonvertebral fractures, increased BMD in both early and late menopausal women, and decreased biochemical measures of bone resorption. " 01/01/2000 - "In this early phase II study, we analyzed the effects of short-term, high-dose treatment with risedronate, a potent pyridinyl bisphosphonate, on markers of bone resorption and formation. "
10.	Alkaline PhosphataseIBA 01/01/2009 - "Although bone resorption markers gradually decreased throughout the study period, bone alkaline phosphatase significantly increased during the first 4 weeks and then gradually decreased. " 12/01/2014 - "In patients with monostotic disease who have a normal serum total alkaline phosphatase, we suggest that a specific marker of bone formation and bone resorption be measured, although these may still be normal. " 12/01/2014 - "After diagnosis of Paget's disease, we recommend measurement of serum total alkaline phosphatase or, when warranted, a more specific marker of bone formation or bone resorption to assess the response to treatment or evolution of the disease in untreated patients. " 11/01/2011 - "Serum levels of bone resorption marker cross-linked amino-terminal telopeptide of type I collegen (NTx), and bone formation marker bone alkaline phosphatase (BAP) were measured in both groups by enzyme-linked immunosorbent assay. " 04/01/2009 - "Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. "

Therapies and Procedures

1.	Ovariectomy (Oophorectomy) 03/01/2010 - "The purpose of this study was to characterize the patterns of osteocyte apoptosis in relation to bone resorption following ovariectomy to test whether osteocyte apoptosis occurs preferentially in areas known to activate resorption. " 05/01/2004 - "The results of this study emphasize that oil extract of garlic possibly has a positive role in suppressing ovariectomy-induced bone resorption." 02/01/1994 - "The present study thus indicates that an increase of bone resorption which was evaluated by urinary HP and LP occurs in the early stage after oophorectomy. " 12/01/1991 - "In previous studies, we have shown that ovariectomy accelerates bone resorption and 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) inhibits ovariectomy-accelerated bone resorption in female Wistar adult rats. " 01/01/1989 - "Women with increased bone resorption induced by bilateral oophorectomy 1-5 years previously (of a total of 48 women in the study, 20 were controls, and 28 were the treatment group) were studied during a 3 year follow-up. "
2.	Transplants (Transplant) 04/01/2003 - "The process of photooxidation decreased the speed of bone resorption in osteochondral grafts and, thus, improved graft stability and cartilage survival. " 10/01/1987 - "Toothless is an osteopetrotic mutation in the rat characterized by reduced bone resorption, few osteoclasts and failure to be cured by bone marrow transplants from normal littermates. " 04/01/2015 - "The purpose of this study is to evaluate the vertical and horizontal graft bone resorption (GR) in grafted maxillary sinuses and the marginal bone loss (MBL) around implants placed in the sinuses with different prosthetic connections and to determine the effect of other clinical factors on these tissue responses at 6 and 18 months postloading. " 03/01/2015 - "The objectives of this study were to evaluate: (1) the clinical outcome of fresh frozen human allogeneic bone grafts (FFB) used for the reconstruction of severely atrophied edentulous ridges; (2) the survival rate of implants placed in the reconstructed areas; and (3) bone resorption. " 01/01/2015 - "Results of this study seem to demonstrate that FFB does not represent a reliable alternative to AB blocks because of the higher rate of bone exposure and partial loss of the grafts, the lower implant survival, and the higher peri-implant bone resorption in FFB patients."
3.	Injections 01/01/1989 - "In the present study, rats were pretreated with either 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP, 10 mg/kg.day sc), with prevailing inhibitory action on bone mineral formation, or dichloromethylene bisphosphonate (Cl2MBP, 10 mg p/kg.day sc) with prevailing action on bone resorption, or NaCl injections (controls) for 7 days. " 06/01/2009 - "We histomorphometrically evaluated bone resorption at sites of T cell injections and examined the influence of T cells from LPS-immunized mice on osteoclastogenesis in vitro. " 03/01/2006 - "Alveolar bone resorption in normal mice, in SCID mice that lack both B and T cells, and in B cell-reconstituted SCID mice was compared histopathologically after repeated injections of lipopolysaccharide (LPS) into the gingiva. " 01/01/2004 - "In animal models OPG prevents bone loss, and in humans bone resorption can be reduced by injections of OPG. " 06/01/2003 - "Bone resorption markers were significantly reduced during the injection period, but returned to baseline levels after the injections were stopped. "
4.	Tooth Movement 05/01/2004 - "Thus, 1,25-DHCC was found to be more effective in modulating bone turnover during orthodontic tooth movement, because its effects on bone formation and bone resorption were well balanced." 12/01/2009 - "After an overview of histological and biological principles of orthodontically-induced tooth movement, this study focuses on the recent data concerning the occurrence and the treatment of bone resorption associated with orthodontic treatment." 08/01/2009 - "Further, OPG was locally present in excess amounts over RANKL and an increased RANKL/OPG in the study groups could be correlated with an increased bone resorption activity during orthodontic tooth movement." 09/01/1994 - "The purpose of this study was to examine the effect of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate (AHBuBP), a potent blocker of bone resorption, on orthodontic tooth movements in rats. " 07/01/1991 - "This study was undertaken to investigate the stress-strain levels and distribution within the periodontal ligament for various types of physiological and orthodontic force systems, assuming that the bone resorption process, leading to tooth movements, is partly controlled by those conditions. "
5.	Arthroplasty 07/01/2014 - "The aim of this study was to assess the timing and location of cortical bone resorption after total shoulder arthroplasty with an uncemented rectangular stem and investigate its effect on shoulder function up to 5 years after implantation. " 03/01/2008 - "This study compared proximal femoral bone resorption in hybrid total hip arthroplasty cases that had poor or good contact between the collar and proximal medial femoral neck. " 06/05/1998 - "This study demonstrates the use of a molecular biological technique to investigate the possible role of NO in prosthetic loosening and periprosthetic bone resorption following total hip arthroplasty. " 03/01/2015 - "The shape and geometry of femoral implant influence implant-induced periprosthetic bone resorption and implant-bone interface stresses, which are potential causes of aseptic loosening in cementless total hip arthroplasty (THA). " 01/01/2015 - "Bone resorption in the proximal femur due to stress shielding has been observed in a number of conventional cementless implants used in total hip arthroplasty. "