Abstract | BACKGROUND: METHODS AND RESULTS: Short-term treatment (21 days) of healthy subjects (n = 10) did not significantly change blood glucose levels or lipid profile. In contrast, rosiglitazone significantly increased flow-mediated, endothelium-dependent vasodilation already within the first day from 5.3+/-2.7% at baseline to 7.8+/-2.6%, further increasing it to 9.4+/-3.0% at day 21. In addition, the early improvement of endothelium-dependent vasodilation was paralleled by a rapid reduction of serum levels of the biomarkers C-reactive protein (CRP), serum amyloid A (SAA), and sE- selectin. Moreover, after drug withdrawal all markers remained suppressed for the whole follow-up period of 7 days. In contrast, rosiglitazone treatment did not significantly affect tumor necrosis factor ( TNF)-alpha, interleukin (IL)-6, sICAM-1, sVCAM-1, and sCD40L levels. CONCLUSIONS: Our study suggests a direct effect of TZD treatment on endothelial function and inflammatory biomarkers of arteriosclerosis, promoting the concept that TZDs, independent of their metabolic action, may exhibit protective effects in the vessel wall.
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Authors | Jürgen Hetzel, Bernd Balletshofer, Kilian Rittig, Daniel Walcher, Wolfgang Kratzer, Vinzenz Hombach, Hans-Ulrich Häring, Wolfgang Koenig, Nikolaus Marx |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 25
Issue 9
Pg. 1804-9
(Sep 2005)
ISSN: 1524-4636 [Electronic] United States |
PMID | 16002742
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- E-Selectin
- Hypoglycemic Agents
- Serum Amyloid A Protein
- Thiazolidinediones
- Rosiglitazone
- C-Reactive Protein
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Topics |
- Adult
- Atherosclerosis
(drug therapy, immunology)
- Biomarkers
- C-Reactive Protein
(metabolism)
- E-Selectin
(blood)
- Endothelium, Vascular
(drug effects, immunology)
- Humans
- Hypoglycemic Agents
(administration & dosage)
- Male
- Rosiglitazone
- Serum Amyloid A Protein
(metabolism)
- Thiazolidinediones
(administration & dosage)
- Vasculitis
(drug therapy, immunology)
- Vasodilation
(drug effects)
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