Vascular Diseases (Vascular Disease)

Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.

Also Known As:

Networked: 10289 relevant articles (350 outcomes, 1085 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Atherosclerosis
2.	Stroke (Strokes)
3.	Hypertension (High Blood Pressure)
4.	Inflammation
5.	Cardiovascular Diseases (Cardiovascular Disease)

Experts

1.	Chalmers, John: 33 articles (10/2015 - 01/2003)
2.	Woodward, Mark: 27 articles (10/2015 - 06/2003)
3.	Visseren, Frank L J: 22 articles (10/2015 - 02/2007)
4.	Lip, Gregory Y H: 21 articles (12/2015 - 06/2004)
5.	Patel, Anushka: 21 articles (12/2014 - 08/2006)
6.	Hultberg, Björn: 21 articles (01/2013 - 01/2005)
7.	van der Graaf, Yolanda: 20 articles (02/2015 - 02/2007)
8.	Poulter, Neil: 19 articles (01/2015 - 04/2009)
9.	Yusuf, Salim: 19 articles (12/2014 - 03/2002)
10.	Nilsson, Karin: 19 articles (01/2013 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Diseases:

1.	CollagenIBA 01/01/2012 - "Although chest radiography is most often used for screening and monitoring of thoracic alterations, high-resolution computed tomography can provide additional information about lung involvement in collagen vascular diseases and may be especially helpful for differentiating specific disease patterns in the lung. " 12/01/1979 - "Treatment of the underlying collagen-vascular disease improved the eruption, while recurrence coincided with exacerbation of the systemic disease. " 01/01/2014 - "Thoracic Imaging Findings of Collagen Vascular Diseases: A CT Study." 01/01/2014 - "The proposed in vitro study using bio-inspired collagen films could potentially be used in the size- and ligand-based design of drugs to treat endothelial dysfunction caused by circulatory vascular diseases." 01/01/2014 - "21 fetuses of pregnant women with collagen vascular diseases were included in the study group and 59 healthy fetuses served as controls. "
2.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/2006 - "Forty two percent of patients were regular aspirin users, and were comparable to the non aspirin group, apart from having a significantly greater prevalence of atherosclerotic vascular disease. " 01/01/2005 - "Aspirin reduces the risk of thrombotic events in a broad range of patients with vascular disease and, in selected individuals, is beneficial for primary prevention. " 10/01/1994 - "Although both high- and low-dose aspirin therapies are effective for secondary prophylaxis in patients with atherosclerotic vascular disease, the acute response to low-dose aspirin therapy is controversial. " 01/01/2014 - "Aspirin (ASA) is the mainstay of treatment in cerebrovascular and systemic vascular disease. " 11/01/2010 - "Aspirin is effective for the prevention of cardiovascular events in patients with a history of vascular disease, as so-called secondary prevention. "
3.	Retinaldehyde (Retinal)IBA 01/01/2012 - "Improved knowledge of these features may be important for understanding pathogenic mechanisms underlying retinal vascular diseases." 01/01/2013 - "ASCs may represent an innovative cellular therapy for protection against and repair of DR and other retinal vascular diseases." 05/01/2013 - "Future studies should focus on the role of this cell type for regulating retinal blood flow and for retinal vascular disease." 12/01/2012 - "The proposed method aims to restore the topology of the vascular trees with anatomical realism for clinical studies and diagnosis of retinal vascular diseases, which manifest abnormalities in either venous and/or arterial vascular systems. " 01/01/2012 - "The results obtained from the present studies may help our understanding the pathogenesis of the retinal vascular disease associated with high levels of CRP."
4.	CholesterolIBA 03/01/2011 - "Vascular disease: cholesterol-efflux capacity might be the key to the protective effects of HDL." 03/01/2014 - "Large-scale randomized controlled trials (RCTs) have well demonstrated the beneficial effects of cholesterol-lowering treatment with statins in patients at high risk of vascular disease. " 11/01/2013 - "Selection criteria included English language, peer-reviewed studies that quantitatively examined the relationship between noninvasively measured skin cholesterol levels and indices of vascular disease or cardiovascular risk factors in human subjects. " 01/01/2013 - "The purpose of this study was to investigate FA and cholesterol synthesis in individuals with type 1 diabetes, a group at elevated risk for vascular disease, using stable isotope analysis. " 02/01/2010 - "Predicted effects of 5 mmHg reductions in mean systolic blood pressures and 0.5 mmol l(-1) reductions in mean total blood cholesterol concentrations on deaths and years of life lost (YLL) per 100,000 person-years from vascular diseases were modelled using proportional risk coefficients from meta-analyses of cohort studies and randomized controlled trials. "
5.	HomocysteineIBA 11/01/2000 - "However, the evidence needs to be strengthened by a systematic review of all comparable studies and the demonstration, in randomised trials, that lowering total homocysteine is followed by a significant reduction in atherothrombotic vascular disease. " 10/01/2004 - "Homocysteine is a risk factor for vascular diseases, and lowering of plasma total homocysteine (tHcy) may be beneficial for health. " 05/01/2000 - "To date, no randomized clinical trial has demonstrated that lowering of homocysteine levels is beneficial in terms of reducing the prevalence of vascular disease. " 02/01/1990 - "These data show that a substantial proportion of patients with early-onset vascular disease have impaired homocysteine metabolism, which may contribute to vascular disease, and that the impaired metabolism can be improved easily and without side effects." 12/01/2012 - "To elucidate this, a retrospective statistical analysis was done of data generated in the course of our study on homocysteine and vascular disease. "
6.	Lipoproteins (Lipoprotein)IBA 01/17/2000 - "Elevated levels of plasma high density lipoprotein (HDL) are strongly predictive of protection against atherosclerotic vascular disease. " 01/01/2013 - "This study indicates that a long-term exposure to pesticides may play an important role in the development of vascular diseases via metabolic disorders of lipoproteins, lipid peroxidation and oxidative stress, inhibition of BChE and decrease in thiolactonase-PON levels. " 12/01/2009 - "Finally competing risk, conditioning the timing and occurrence of vascular events in our study population, could be a correct approach for evaluating the role of Lp(a) lipoprotein in vascular disease among elderly people." 12/01/2005 - "Despite this evidence and the national clinical guidelines recommending lipid-lowering treatment and low-density lipoprotein (LDL) goal attainment in patients with clinically evident atherosclerotic vascular disease or similar risk, study after study has documented low treatment rates. " 04/15/2004 - "In OC and HRT users, this leads to a range of different lipoprotein profiles, which may differ from those evaluated with respect to vascular disease risk in population studies. "
7.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 04/01/2011 - "Results of the main randomized clinical trials that evaluated the benefit of ACE inhibitors in patients with vascular disease are discussed in this editorial. " 05/01/2010 - "Some studies have also demonstrated the statistical equivalence of ARBs to ACE inhibitors in certain populations (e.g., among post-MI patients in VALIANT and among a broad population of patients with vascular disease or diabetes in the ONTARGET). " 04/01/2005 - "ACE inhibitors in patients with vascular disease: should the PEACE trial change medical practice?" 02/01/2002 - "A large body of experimental evidence reporting that ACE inhibitors limit these effects has formed the rationale for major clinical trials of these drugs in the management of atherosclerotic vascular disease. " 11/21/2001 - "Recent trials of ACE inhibitors in patients with vascular disease who do not have the traditional indications for ACE inhibition have shown a reversal of endothelial dysfunction and a reduction in adverse clinical endpoints. "
8.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 12/01/2004 - "Antiplatelet agents are effective in preventing recurrence of vascular events among patients with established vascular disease or with multiple risk factors. " 10/20/2004 - "Antiplatelet agents, used alone or in combination, are effective in preventing recurrent vascular events among individuals with established vascular disease. " 01/01/1985 - "We conclude that this study should provide definitive data on the efficacy of these antiplatelet agents in preventing further vascular disease in this patient group. " 12/01/2011 - "Sophisticated imaging protocols have minimized the need for invasive methods, and the efficacy of medical therapy (with newer antiplatelet agents and statins) has improved outcomes related to vascular disease. " 02/01/2013 - "Studies of inherited platelet disorders have led to major advances in our knowledge of platelet physiology, thus permitting the development of antiplatelet agents that are now widely used to treat vascular diseases. "
9.	clopidogrel (Plavix)FDA Link 08/15/2004 - "Clopidogrel is superior to ASA in patients with high risk of recurrence due to concomitant vascular disease or multiple risk factors. " 03/01/2002 - "These results demonstrated that long-term administration of clopidogrel was effective in preventing ischaemic events in patients with atherosclerotic vascular disease including PAD. " 05/01/2008 - "Clinical trials have helped clarify the efficacy of clopidogrel for the treatment and prevention of vascular disease. " 05/02/2007 - "Large multi-center clinical trials have indicated significant clinical benefits for patients with atherosclerotic vascular diseases receiving clopidogrel therapy. " 06/01/2014 - "Clopidogrel therapy has recently been shown to reduce cardiovascular events in patients with stable vascular disease. "
10.	LDL CholesterolIBA 06/01/2012 - "Statins are widely used and have been proven to be effective in the prevention of atherosclerotic vascular disease events, primarily by reducing plasma low-density lipoprotein cholesterol concentrations. " 08/11/2012 - "The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials." 12/01/2015 - "With the goal of decreasing low-density cholesterol (LDL-C) to mitigate risk of both primary and secondary cardiovascular outcomes, statins have been the cornerstone of therapy, significantly reducing the incidence of coronary atherosclerotic vascular disease. " 03/09/2015 - "Normal genetic variations in PCSK9 have a great impact on low-density lipoprotein cholesterol levels and hence the risk of cardio-vascular disease. " 02/15/2015 - "In the present prospective cohort study of 4,645 patients with established vascular disease without DM at baseline, 3,057 patients used statins at baseline, of whom 1,608 used intensive statin therapy, defined as statin therapy theoretically lowering low-density lipoprotein cholesterol with ≥40%. "

Therapies and Procedures

1.	Transplants (Transplant) 10/01/2015 - "Donor AAC is predictive of renal vascular disease and may help to improve the screening of potential donors and inform post-transplant management." 03/11/1982 - "We hope that such transplants may ultimately provide an improved outlook for selected terminally ill patients with pulmonary vascular disease and certain other intractable cardiopulmonary disorders." 06/01/2015 - "This is the first study to describe a significant regional change in the pulmonary vessels of patients without known pulmonary vascular disease who undergo liver transplant." 03/01/2014 - "Our study highlights the role of macrophages in directing vascular stem/progenitor cell lineage commitment through TNF-α-mediated TNF-α receptor 1 and nuclear factor-κB activation that is likely required for endothelial repair in vascular diseases such as vein graft." 03/01/2011 - "This review describes the mainly in vitro and in vivo studies used to define the molecular role hemodynamics have in vascular disease and its usage in developing tissue engineered vascular bypass grafts."
2.	Transplantation (Transplant Recipients) 01/01/1994 - "In humans, the cerebral cortex can be affected by a variety of diseases (vascular, traumatic, neurodegenerative, etc.) and, therefore, several experimental studies have been undertaken to determine to what extent transplantation of cortical neurons could prove a useful treatment for cerebral cortical damage. " 03/01/2010 - "Despite improved medical therapy, transplantation (Tx) represents the only option for end-stage pulmonary vascular disease. " 01/01/2012 - "Orthotopic aortic transplantation in mice for the study of vascular disease." 09/01/2008 - "This study was designed to address characteristics of extracoronary vascular disease in heart transplant recipients. " 06/01/2015 - "As vascular diseases are becoming more prevalent among renal transplant recipients, complications related to renal artery anastomosis are likely to occur more often. "
3.	Stents 05/04/2010 - "The use of stents for vascular disease has resulted in a paradigm shift with significant improvement in therapeutic outcomes. " 04/01/2002 - "Vascular stents have emerged as an effective treatment for occlusive vascular disease. " 12/05/2005 - "Other animal studies have shown that vascular stents used to relieve arterial obstruction can also be used as gene delivery systems to provide therapeutic vector constructs that can both locally prevent post stenting reobstruction, known as in-stent restenosis, and treat the underlying vascular disease. " 02/01/2005 - "With the recent advances in renal artery stent revascularization, a procedure that can be accomplished with <1% major complication rate, 90-95% success rate and 10-15% restenosis rate, multiple studies have reported the salutary hemodynamic benefits and increased awareness of prevalence of RAS in patients with vascular disease. " 01/01/2015 - "The physical properties of the stent surface influence the effectiveness of vascular disease treatment after stent deployment. "
4.	Amputation 09/01/2014 - "The purpose of this study was to explore the perspectives of patients who have undergone a major lower limb amputation as a result of vascular disease, regarding the information healthcare professionals should provide to them during their acute hospital stay. " 01/01/2012 - "The study design was a multicenter prospective cohort study of individuals undergoing their first major lower-limb amputation because of vascular disease and/or diabetes. " 06/01/2011 - "The study comprised 28 individuals (20 males, eight females, mean age 49 years) with a unilateral amputation due to reasons other than vascular disease and 31 healthy volunteers (20 males, 11 females, mean age 47 years). " 04/01/2010 - "The results of this study help to understand the challenge of every-day live after a lower limb amputation caused by vascular diseases, which should serve for a basis of support for these people." 04/01/2010 - "This study examines how people with a lower-limb amputation caused by vascular diseases experience and manage their every-day life. "
5.	Angioplasty (Angioplasty, Transluminal) 12/01/1990 - "We recommend angioplasty as the first line treatment for ischaemic or neurological symptoms in upper limb vascular disease." 01/01/1983 - "We evaluated the diagnostic accuracy and complications of digital subtraction angiography (DSA) in a series of clinical trials conducted on patients primarily with cerebral vascular disease and those evaluated before and after surgery or percutaneous transluminal angioplasty. " 04/01/2013 - "The authors envision that DCB angioplasty will evolve to a major paradigm shift in the endovascular treatment of occlusive vascular diseases." 01/01/2010 - "Angioplasty of the coronary arteries has made significant headway in the past 20 years as a treatment for atherosclerotic vascular disease. " 08/01/2009 - "We conclude that TA should be investigated further as a potential tool for the prevention and treatment of proliferative vascular diseases, particularly in the setting of post-angioplasty restenosis."