Selectins

Transmembrane proteins consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable number of domains that are homologous to complement regulatory proteins. They are important cell adhesion molecules which help LEUKOCYTES attach to VASCULAR ENDOTHELIUM.

Also Known As:

Networked: 1898 relevant articles (65 outcomes, 283 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Borsig, Lubor: 23 articles (01/2020 - 02/2002)
2.	King, Michael R: 19 articles (12/2017 - 11/2007)
3.	Konstantopoulos, Konstantinos: 17 articles (11/2017 - 08/2003)
4.	Schumacher, Udo: 14 articles (11/2022 - 05/2011)
5.	McEver, Rodger P: 14 articles (01/2020 - 09/2002)
6.	Schalkwijk, Casper G: 13 articles (01/2022 - 03/2004)
7.	Stehouwer, Coen D A: 12 articles (01/2022 - 03/2004)
8.	Nomura, Shosaku: 12 articles (01/2018 - 02/2003)
9.	Wicklein, Daniel: 10 articles (06/2022 - 08/2012)
10.	Kannagi, Reiji: 10 articles (01/2020 - 07/2002)

Related Diseases

1.	Inflammation (Inflammations) 07/01/1995 - "Selectin-directed therapeutic agents are now proven to be effective in blocking many of the pathological effects resulting from leukocyte entry into sites of inflammation. " 02/14/2008 - "We also found a significant negative association between sE-selectin and FMD, indicating an possible association between inflammation and dysfunction of the vascular endothelium; however further studies are required to confirm this preliminary finding." 04/01/2004 - "The aim of this study was to investigate whether sCAMs, sICAM-1, sVCAM-1, and sE-Selectin were present in GCF in both periodontal health and disease and to examine their relationship with periodontal inflammation. " 11/01/2003 - "Studies in several models of inflammation have underscored the importance of P- and E-selectins in the migration of T cells to inflamed tissues. " 10/01/1998 - "Recent studies have indicated that selectins (E,L,P) are implicated in cell trafficking, an important aspect of inflammation-related process. "
2.	Neoplasms (Cancer) 01/01/2009 - "Our findings suggest that an improved understanding of the mechanisms of membrane shedding of sICAM, sVCAM and sE-selectin is required to delineate their role in tumor progression." 01/01/2020 - "An integrated photoconversion and cell sorting parallel-plate chromatography channel enabling the measurement of instantaneous and average velocities of cells mediating adhesion in flow fields was engineered to study the mechanisms underlying adhesion to selectins by metastatic cancer cells. " 02/15/2013 - "The level of sP-selectin was lowest in early cancer and was observed to increase after surgery in all the study patients. " 03/15/2009 - "This study reveals a role for selectins in NK cell recruitment to tumors and in regulation of effective tumor immunity." 06/01/2003 - "In this study, the time course of the TNalpha-induced accumulation in the blood of three circulating soluble adhesion molecules, sE-selectin, sICAM-1 and sVCAM-1, was studied in plasma samples of tumor patients enrolled in a phase I trial receiving TNalpha. "
3.	Ischemia 07/01/2014 - "The aim of this study was to test the hypothesis that molecular imaging of selectins with myocardial contrast echocardiographic (MCE) molecular imaging could be used to detect recent brief ischemia in closed-chest nonhuman primates. " 01/18/2005 - "The goal of this study was to assess whether selectin blockade reduces myocardial platelet deposition and platelet-mediated injury after transient ischemia. " 01/01/2015 - "Microenviromental change after synthetic E-selectins interfere in ischemia-reperfusion in rats and its contribution to endogenetic/exogenous never stem cells." 07/01/2014 - "On selectin-targeted MCE molecular imaging, signal enhancement was greater (P < .05) in the risk area than remote territory at 30 min (25 ± 11 vs 11 ± 4 IU) and 90 min (13 ± 3 vs 3 ± 2 IU) after ischemia. " 04/01/2014 - "Two and 5 hours after ischemia has resolved, a persistent expression of these 2 selectins was detected. "
4.	Reperfusion Injury 12/01/1998 - "Selectin blockade may be effective in reducing the contribution of leukocytes to early reperfusion injury." 04/01/2007 - "Finally, inhibition of selectin functions was studied in an ischemia/reperfusion injury model in rats. " 03/01/2007 - "Though the timing of selectin inhibition is essential in attenuating leukocyte infiltration and cell-mediated injury, the transient blockade of selectin function, in a well-controlled setting, could be an extremely beneficial intervention in ischemia/reperfusion injury." 01/01/2007 - "The endothelial reperfusion injury after OLT is characterized by increased vWF and sTM but not by sP-selectin in peripheral blood." 05/01/2006 - "Experiments in rodents have demonstrated an important role for selectins in kidney ischemia-reperfusion injury (IRI). "
5.	Asthma (Bronchial Asthma) 09/01/2009 - "This study was undertaken to assess the levels of sICAM-1 and sE-selectin during an acute attack of asthma in adults and children and to establish normal values (95th percentile) in healthy control subjects. " 01/01/2006 - "The result of this proof-of-concept exploratory trial is the first study that demonstrates clinical efficacy of selectin-antagonists as novel therapeutic strategy in asthma." 04/01/2002 - "This study provides further evidence that serum concentrations of sICAM-1, sVCAM-1, and sE-selectin are increased in acute asthma. " 05/01/2015 - "The mean plasma levels of sL-selectin was significantly higher in the patients with asthma than the controls (2113 ± 466 vs. 1664 ± 322 ng/ml, P = 0.001). " 08/11/2011 - "To explore the collective role of E-, L-, and P- selectins in OVA-induced Th2 mediated response in acute asthma pathophysiology, ELP-/- mice were used and compared with age-matched wildtype (WT). "

Related Drugs and Biologics

1.	Ligands
2.	bimosiamose
3.	Biomarkers (Surrogate Marker)
4.	Monoclonal Antibodies
5.	Interleukin-6 (Interleukin 6)
6.	Polysaccharides (Glycans)
7.	Proteins (Proteins, Gene)
8.	fucoidan
9.	Peptides (Polypeptides)
10.	oxidized low density lipoprotein

Related Therapies and Procedures

1.	Therapeutics
2.	Thrombolytic Therapy
3.	Transplantation
4.	Immunotherapy
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)