Abstract |
Body size at birth is an indicator of the intrauterine environment. The effects of the Pro12Pro genotype and the 12Ala allele of the PPARgamma-2 gene on glucose and insulin metabolism in adult life depend on body size at birth. A low birth weight is associated with insulin resistance and type 2 diabetes. The peroxisome proliferator-activated receptor-gamma (PPARgammas) are also regulators of adipocyte differentiation, and the PPARgamma-2 gene could also contribute to the development of dyslipidemia. Therefore, the effects of the Pro12Ala polymorphisms of the PPARgamma-2 gene on lipid metabolism were measured in 476 elderly persons whose birth weight was known. The Ala12 allele was associated with increased serum total, low-density lipoprotein ( LDL), and non- high-density lipoprotein (non- HDL) cholesterol concentrations but only among those who had birth weights below 3000 g. These interactions between the effects of the PPARgamma-2 gene on adult traits and the effects of birth weight may be interpreted as examples of gene-environmental interactions, which underlie plasticity during development.
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Authors | J Eriksson, V Lindi, M Uusitupa, T Forsén, M Laakso, C Osmond, D Barker |
Journal | Clinical genetics
(Clin Genet)
Vol. 64
Issue 4
Pg. 366-70
(Oct 2003)
ISSN: 0009-9163 [Print] Denmark |
PMID | 12974743
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Lipoproteins, HDL
- Lipoproteins, LDL
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors
- Triglycerides
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Topics |
- Aged
- Alleles
- Birth Weight
(genetics)
- Cohort Studies
- Finland
- Humans
- Lipid Metabolism, Inborn Errors
(genetics)
- Lipoproteins, HDL
(blood)
- Lipoproteins, LDL
(blood)
- Polymorphism, Genetic
- Receptors, Cytoplasmic and Nuclear
(genetics)
- Transcription Factors
(genetics)
- Triglycerides
(blood)
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