Abstract | BACKGROUND AND AIMS: The natural immunomodulator, lactoferrin, is widespread among various biological fluids and is known to exert an anti-inflammatory effect. However, there has been only one study that examined the mode of action of lactoferrin in reducing intestinal damage. We investigated the therapeutic role of lactoferrin and its effect on the levels of pro-inflammatory and anti-inflammatory cytokines, by using a rat model of dextran sulfate sodium (DSS) induced- colitis. METHODS: Male Sprague-Dawley rats were given distilled drinking water containing 2.5% (wt/vol) synthetic DSS ad libitum. Bovine lactoferrin was given once daily through gavage, starting 3 days before beginning the DSS administration, until death. The whole colon was removed to be examined macroscopically and histologically. Myeloperoxidase activity, and pro-inflammatory and anti-inflammatory cytokines in the colonic tissue were also measured. RESULTS: CONCLUSIONS:
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Authors | Jun-Ichi Togawa, Hajime Nagase, Katsuaki Tanaka, Masahiko Inamori, Atsushi Nakajima, Norio Ueno, Toshifumi Saito, Hisahiko Sekihara |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 17
Issue 12
Pg. 1291-8
(Dec 2002)
ISSN: 0815-9319 [Print] Australia |
PMID | 12423274
(Publication Type: Journal Article)
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Copyright | Copyright 2002 Blackwell Publishing Asia Pty Ltd |
Chemical References |
- Cytokines
- Dextran Sulfate
- Peroxidase
- Lactoferrin
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Topics |
- Administration, Oral
- Animals
- Cattle
- Colitis
(chemically induced, drug therapy)
- Colon
(metabolism)
- Cytokines
(metabolism)
- Dextran Sulfate
- Dose-Response Relationship, Drug
- Lactoferrin
(administration & dosage, therapeutic use)
- Male
- Peroxidase
(metabolism)
- Rats
- Rats, Sprague-Dawley
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