Abstract | OBJECTIVES: METHODS: A total of 104 patients with a J-pouch who were operated on between 1985 and 1994, as well as 21 ulcerative colitis patients with a conventional ileostomy were enrolled for the study. Routine blood tests, vitamin status, vitamin B12 levels, and bile acid absorption were determined, as well as endoscopy with biopsies. The pouchitis disease activity index (PDAI) was calculated. On the basis of histology, IPAA patients were divided into three subgroups: 1) those with no villous atrophy, 2) those with partial villous atrophy, and 3) those with subtotal or total villous atrophy. RESULTS: CONCLUSIONS: Metabolic consequences after IPAA are associated with pouchitis, grade of villous atrophy, and extent of inflammation in the remaining ileum. Patients with active chronic inflammation need long term follow-up.
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Authors | J Kuisma, H Nuutinen, P Luukkonen, H Järvinen, A Kahri, M Färkkilä |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 96
Issue 11
Pg. 3110-6
(Nov 2001)
ISSN: 0002-9270 [Print] United States |
PMID | 11721757
(Publication Type: Journal Article)
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Chemical References |
- Bile Acids and Salts
- Lipids
- Vitamin B 12
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Topics |
- Adult
- Aged
- Atrophy
- Bile Acids and Salts
(metabolism)
- Colitis, Ulcerative
(surgery)
- Female
- Humans
- Lipids
(blood)
- Male
- Middle Aged
- Pouchitis
(metabolism, pathology)
- Time Factors
- Vitamin B 12
(metabolism)
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