Fat distribution, not
overweight and
obesity per se, are supposed to be associated with hemodynamic,
hemostatic and other metabolic disturbances (
insulin resistance,
hyperuricemia and
dyslipidemia). Moreover,
obesity increases the total risk of
cardiovascular disease. Oxidative modification of
lipoproteins, especially of
LDL, is supposed to play a key role in the initiation and progression of
atherosclerosis. Therefore we analysed VLDL a
LDL composition and Cu(2+)-catalyzed conjugated diene formation in both
lipoprotein fractions in patients with intraabdominal fat accumulation and in control group. Patients (33, 12 M/21 F) with intraabdominal fat accumulation (WHCR 1.00 for men, 0.85 for women) revealed, in comparison with control group (72, 47 M/25 F), after adjustment for the same age, increased plasma total
cholesterol,
apolipoprotein B, non-
esterified fatty acid concentrations, and systolic blood pressure as well. In the group of patients increased levels of
cholesterol,
triglycerides,
phospholipids,
proteins and
apolipoprotein B (only in the fraction of VLDL) were found in the both VLDL and
LDL fractions. In this group of patients increased concentrations of conjugated dienes in VLDL and decreased length of lag phase of VLDL were found. Parameters of conjugated diene formation of
LDL (basal absorbance, length of lag phase, propagation phase) did not differ significantly from controls. Concomitantly, persons with intraabdominal fat distribution showed decreased titres of
antibodies against oxidative modified
LDL. The results indicated that the patients with intraabdominal fat accumulation revealed not only adverse composition of VLDL and
LDL particles, but also increased VLDL oxidation and oxidability.