Abstract | BACKGROUND: METHODS: This article reviews the pharmacology of bisphosphonates and the relation between the chemical structure of bisphosphonates and antiresorptive potency, and describes recent new discoveries of their molecular mechanisms of action in osteoclasts. RESULTS: CONCLUSIONS:
Bisphosphonates are highly effective inhibitors of bone resorption that selectively affect osteoclasts. After more than 30 years of clinical use, their molecular mechanisms of action are only just becoming clear.
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Authors | M J Rogers, S Gordon, H L Benford, F P Coxon, S P Luckman, J Monkkonen, J C Frith |
Journal | Cancer
(Cancer)
Vol. 88
Issue 12 Suppl
Pg. 2961-78
(Jun 15 2000)
ISSN: 0008-543X [Print] United States |
PMID | 10898340
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Diphosphonates
- Protein Tyrosine Phosphatases
- Proton-Translocating ATPases
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Topics |
- Animals
- Bone Resorption
(drug therapy)
- Bone and Bones
(drug effects)
- Diphosphonates
(pharmacokinetics, pharmacology)
- Humans
- Osteoblasts
(drug effects)
- Osteoclasts
(drug effects)
- Protein Prenylation
(drug effects)
- Protein Tyrosine Phosphatases
(antagonists & inhibitors)
- Proton-Translocating ATPases
(antagonists & inhibitors)
- Structure-Activity Relationship
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