Hypercalcemia (Milk Alkali Syndrome)

07/01/2007 - "Besides the very expensive non-calcium based phosphate binders, at least two common tools may be helpful in the treatment of hypercalcemia and adynamic bone. "
10/01/1990 - "In conclusion, the combined treatment is rapidly effective and safe in the treatment of patients with hypercalcemia, particularly when the notional setting of renal tubular reabsorption of calcium is increased and a rapid correction of the plasma calcium level is needed."
05/01/2014 - "Calcium-based binders are still very useful but can lead to hypercalcemia and/or positive calcium balance and cardiovascular calcification. "
01/01/2011 - "All patients recovered after surgery, with serum calcium levels restored back to normal and with resolution of all symptoms of hypercalcemia. "
01/01/2003 - "In patients with malignant hypercalcemia, the efficacy of the individual bisphosphonate depends on dose administered and initial serum calcium concentration. "

08/01/1991 - "All three are useful for the treatment of hypercalcemia, but pamidronate seems to be the most effective. "
11/01/2007 - "Pamidronate therapy seems to be safe in the short-term and effective in helping control hypercalcemia even in the very premature infant, allowing for planned surgical intervention when it becomes feasible."
06/01/1996 - "We report two cases of PHPT in which intravenous pamidronate effectively reduced hypercalcemia and significantly improved the clinical symptoms. "
01/01/1988 - "We conclude that APD is a valuable supplement to the treatment of malignant hypercalcemia in that it may be effective when traditional therapies have failed."
12/01/2002 - "Although treatment of hypercalcemia with pamidronate is palliative, it is effective against the deterioration of quality of life."

01/01/2003 - "Bisphosphonates are the best therapeutic for osteolytic hypercalcemia. "
01/01/2006 - "Bisphosphonates and a new class of drugs known as calcimimetics have been used effectively in some patients to control the symptoms of severe hypercalcemia in a palliative setting."
01/01/2000 - "Glucocorticoid therapy and bisphosphonates are effective in treating associated hypercalcemia. "
01/01/1995 - "Earlier studies have shown it to be one of the most active bisphosphonates in Paget's disease and the hypercalcemia of malignancy. "
05/01/2015 - "Our experience suggests that bisphosphonates may be an effective and reliable drug in the treatment of severe and persistant hypercalcemia. "

10/01/2007 - "These anabolic effects occurred in association with hypercalcemia and were significantly greater than those achievable with high concentrations of daily PTH(1-34). "
07/01/2004 - "Is there enough evidence that evening dosing is more beneficial with respect to suppression of parathyroid hormone and reduction of side effects such as hypercalcemia?"
05/01/1994 - "Inactivation by plasma may be responsible for lack of efficacy of parathyroid hormone antagonists in hypercalcemia of malignancy."
08/01/1988 - "Improved differential diagnosis of hypercalcemia by hypocalcemic stimulation of parathyroid hormone secretion."
01/01/1992 - "In the present study, a possible involvement of parathyroid hormone (PTH) in the development of hypercalcemia in rat was studied by using a newly-developed sensitive and specific radioimmunoassay system for the determination of rat PTH. "

01/01/2010 - "Recent observational studies have indeed indicated that vitamin D treatment was associated with a significant reduction of cardiovascular death among dialysis patients, and a reduction in LVH; in contrast, other studies suggested that excess vitamin D contributes to risk of hypercalcemia and vascular calcification, which is associated with reduced survival and morbidity. "
07/01/2013 - "Hypercalcemia improved in >90% of patients, including eight patients treated solely with vitamin D supplement withdrawal. "
06/01/2012 - "Furthermore, this review summarizes the preclinical and clinical studies of vitamin D and its analogs over the past decade, indicating the current problems of dose-limiting toxicity from hypercalcemia and large interpatient variability in pharmacokinetics. "
07/01/2007 - "Vitamin D metabolites had to be discontinued in 26 patients (37.1% of those receiving them from study start) due to hyperphosphoremia or hypercalcemia post-K/DOQI; and serum PTH significantly increased (445.8 +/- 238.2 pg/mL vs. 715.2 +/- 549.5 pg/mL; p<0.001). "
12/21/1987 - "A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcemia."

11/01/2011 - "After forced hydration and administration of furocemide and calcitonin, hypercalcemia was improved. "
02/01/1970 - "Importance of endogenous thyrocalcitonin for protection against hypercalcemia in the rat."
01/01/2006 - "The conflicting results of previous evaluations of the influence of hypercalcemia on thyroid C-cells and the absence of reports on its influence on calcitonin (CT)-producing cells of the airways prompted this study. "
01/01/1979 - "Studies of calcitonin cells and parathyroid gland of house shrew, Suncus murinus in response to experimental hypercalcemia."
04/01/2015 - "Calcitonin has an immediate effect on decreasing osteoclast activity and has been used for treatment of hypercalcemia. "

11/01/2012 - "Cinacalcet was effective for long-term control of hypercalcemia related to persistent HPT for patients with stable KT."
06/01/2011 - "Cinacalcet has proved efficient in short- and long-term controls of hypercalcemia and, though bone mineral density was not improved, the available data point to cinacalcet as the treatment of choice in non-operable patients with pHPT. "
11/01/2012 - "We aimed to evaluate the long-term efficacy of cinacalcet in functioning stable KT subjects with hypercalcemia secondary to persistent HPT. "
01/01/2011 - "Three months after the initiation of cinacalcet treatment, all our patients experiencing clinical signs of hypercalcemia had improved in self -reported well-being and in biochemical parameters. "
07/01/2009 - "We sought to analyze the efficacy of treatment with cinacalcet for patients with hypercalcemia (Ca > 10.5 mg/dL) secondary to HPT. "

09/01/2005 - "ALL relapsed in the bone marrow 3 months after achieving complete remission, and hypercalcemia and elevation of serum PTHrP were also observed. "
11/01/1992 - "Clinically, selected PTHRP assays can be very helpful in diagnosing PTHRP-mediated hypercalcemia, but are not yet sufficiently sensitive to accurately measure normal concentrations of the protein."
09/01/1997 - "On the other hand, the frequency of patients with abnormally high plasma levels of PTHrP was significantly greater (2/9 for normocalcemia vs 5/6 for hypercalcemia, chi 2 = 5.20, p = 0.02) in patients with hypercalcemia than in normocalcemic patients. "
04/01/1994 - "Our data show that effective treatment of malignancy-associated hypercalcemia is not associated with a consistent change in serum levels of PTHrP. "
09/01/2004 - "Thus, humanized anti-PTHrP may be useful for the treatment of the humoral hypercalcemia of malignancy in humans."

06/01/2006 - "Administration of gallium nitrate in vivo is highly effective in treatment of flare hypercalcemia."
03/01/1992 - "Gallium nitrate is effective in the treatment of hypercalcemia associated with malignancy and is appropriate for formulary addition. "
01/01/1995 - "The purpose of this study was to histomorphometrically investigate the ultrastructural effects of gallium nitrate on osteoclasts and osteoblasts in trabecular bone of normal nude mice and nude mice with humoral hypercalcemia of malignancy. "
03/01/1992 - "Two Phase III comparative trials evaluating gallium nitrate in the treatment of hypercalcemia of malignancy have been completed. "
01/01/2006 - "We evaluated the effect of such a drug, gallium nitrate, on flare hypercalcemia. "

12/01/2007 - "Because of the propensity of bioactive 1,25-dihydroxyvitamin D3 to cause toxic hypercalcemia, considerable effort has been directed to identifying safer drugs while retaining the efficacy of the parent compound. "
10/01/2013 - "The objective of the study was to systematically identify a large series of cases of calcitriol-mediated hypercalcemia and document the presentation, demographics, and clinical course across etiologies. "
11/01/2011 - "In human trials calcitriol and its analogs displayed unacceptable systemic toxicities including hypercalcemia. "
11/01/2006 - "Adverse effects of calcitriol administration (specifically ionized hypercalcemia) were not seen in either feline group during either phase of the study over the 3-day evaluation after calcitriol administration was initiated. "
03/01/2004 - "Such concentrations are not achievable in patients when calcitriol is dosed daily due to predictable hypercalcemia and hypercalcuria; however, phase I trials have demonstrated that intermittent dosing allows substantial dose escalation and has produced potentially therapeutic peak calcitriol concentrations. "

04/01/1982 - "3. Most patients have symptomatic hypercalcemia (73 per cent in our series) and are improved with parathyroidectomy."
01/01/2014 - "Minimally invasive parathyroidectomy (PTx) represents the treatment of choice for symptomatic patients, leading to several advantages, including immediate normalization of hypercalcemia and significant improvement of bone mineral density, cardiovascular dysfunctions, neuropsychological symptoms and quality of life. "
11/01/2008 - "Parathyroidectomy, during the second trimester, is the therapeutic gold standard, especially in cases of severe hypercalcemia (>12 mg/dL)."
10/01/2014 - "Maternal hypercalcemia was resolved after urgent parathyroidectomy. "
04/01/2014 - "Refractory hypercalcemia due to autonomous parathyroid tissue following parathyroidectomy can be managed with greater ease and efficacy by serial explantation of autotransplanted tissue versus a more difficult re-exploration of the neck."

04/01/2015 - "Herein, we describe a 60-year-old Japanese woman on hemodialysis for 35 years who presented with malaise and hypercalcemia. "
03/01/2015 - "Hemodialysis is considered the renal replacement technique of choice to control life-threatening hypercalcemia. "
01/01/2015 - "In this report, we describe the case of a male chronic hemodialysis patient who developed asymptomatic hypercalcemia associated with polyarticular swelling. "
09/01/2013 - "[A case of hypercalcemia in hemodialysis]."
01/01/2013 - "In severe hypercalcemia hemodialysis may be necessary."

01/01/2008 - "Calcimimetics : a promising treatment for persistent hypercalcemia after kidney transplantation]."
01/01/2015 - "Comment on "Management of hypercalcemia after renal transplantation"."
11/13/2013 - "At the time of the renal transplantation (RT), PTH is the factor that determines the development of post-RT hypercalcemia, although it is sometimes masked in patients who are well controlled with medical treatment. "
11/13/2013 - "Management of hypercalcemia after renal transplantation."
08/15/2008 - "Persistent SHP with hypercalcemia is an important factor of bone loss after renal transplantation. "

05/01/1987 - "Parathyroid tissue can survive and function in adipose tissue, as was demonstrated by normocalcemia in 14 patients (whose only probable remaining parathyroid tissue had been transplanted into fat), by the demonstration that graft-dependent hypercalcemia could be eliminated by excision of the transplant, and by the demonstration of viable parathyroid tissue by microscopic examination of excised grafts. "
01/01/2015 - "Participants were excluded from the study if they were unable to give consent, had hypercalcemia, were visually or hearing impaired or were expected to receive a renal transplant during the time of the study. "
03/01/2006 - "In this study, we sought to analyze the effect of persistent hypercalcemia in the posttransplantation period on the function of renal transplants. "
02/01/2014 - "Hypercalcemia in renal transplant patients: prevalence and management in Canadian transplant practice."
11/13/2013 - "Hypercalcemia may have deleterious effects on the renal graft, resulting in tubulointerstitial calcification. "

05/01/2009 - "Though the etiology of this complication remains unclear, our experience suggests that early institution of chemotherapy along with supportive care is the best treatment for control of hypercalcemia."
11/01/1989 - "In one of the patients, chemotherapy induced remission and controlled the hypercalcemia."
01/01/1989 - "Hypercalcemia was well controlled by corticotherapy and chemotherapy, and remained normal after remission was obtained. "
08/01/2015 - "The aim of presenting this case is to highlight the importance of early etiologic treatment through chemotherapy as an urgent treatment in a refractory and severe hypercalcemia case, in order to avoid possible secondary complications due to this electrolyte disturbance. "
09/01/2009 - "After further chemotherapy, the hypercalcemia symptoms were corrected or alleviated. "