Abstract | BACKGROUND: METHODS: We investigated the two patients with infections due to S. aureus with intermediate resistance to glycopeptides, as defined by a minimal inhibitory concentration of vancomycin of 8 to 16 microg per milliliter. To assess the carriage and transmission of these strains of S. aureus, we cultured samples from the patients and their contacts and evaluated the isolates. RESULTS: CONCLUSIONS: The emergence of S. aureus with intermediate resistance to glycopeptides emphasizes the importance of the prudent use of antibiotics, the laboratory capacity to identify resistant strains, and the use of infection-control precautions to prevent transmission.
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Authors | T L Smith, M L Pearson, K R Wilcox, C Cruz, M V Lancaster, B Robinson-Dunn, F C Tenover, M J Zervos, J D Band, E White, W R Jarvis |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 340
Issue 7
Pg. 493-501
(Feb 18 1999)
ISSN: 0028-4793 [Print] United States |
PMID | 10021469
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Vancomycin
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Topics |
- Aged
- Anti-Bacterial Agents
(pharmacology, therapeutic use)
- Bacteremia
(drug therapy, microbiology)
- Contact Tracing
- Diabetes Complications
- Drug Resistance, Microbial
- Electrophoresis, Gel, Pulsed-Field
- Fatal Outcome
- Humans
- Infection Control
- Kidney Failure, Chronic
(complications)
- Male
- Methicillin Resistance
- Michigan
- Microbial Sensitivity Tests
- Middle Aged
- New Jersey
- Peritonitis
(drug therapy, microbiology)
- Staphylococcal Infections
(drug therapy, microbiology)
- Staphylococcus aureus
(drug effects, isolation & purification, ultrastructure)
- Vancomycin
(pharmacology, therapeutic use)
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