ATP Binding Cassette Transporter 1

A superfamily of integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE, characterized by accumulation of cholesteryl ester in various tissues.

Also Known As:

ABCA1 Protein; ATP Binding Cassette Transporter, Subfamily A, Member 1; ATP-Binding Cassette Sub-Family A Member 1; CERP Protein; Cholesterol-Efflux Regulatory Protein; ATP Binding Cassette Sub Family A Member 1; Cholesterol Efflux Regulatory Protein

Networked: 89 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schmitz, G: 4 articles (02/2010 - 02/2000)
2.	Wang, Qi: 3 articles (01/2015 - 03/2014)
3.	Oram, John F: 3 articles (07/2009 - 10/2005)
4.	Qin, Li: 2 articles (09/2021 - 01/2014)
5.	Chen, Wei: 2 articles (01/2018 - 07/2003)
6.	Lu, Rui: 2 articles (01/2018 - 11/2017)
7.	Yokoyama, Shinji: 2 articles (01/2018 - 11/2017)
8.	Zheng, Lu: 2 articles (01/2018 - 01/2014)
9.	Fessler, Michael B: 2 articles (11/2016 - 11/2012)
10.	Gowdy, Kymberly M: 2 articles (11/2016 - 11/2012)

Related Diseases

1.	Atherosclerosis 01/01/2014 - "Influence of ATP-binding cassette transporter 1 R219K and M883I polymorphisms on development of atherosclerosis: a meta-analysis of 58 studies." 01/01/2018 - "We investigated its underlying mechanisms for atherogenesis focusing on regulation of ABCA1 protein decay in macrophages. " 01/01/2015 - "ATP-binding cassette transporter 1 C69T and V825I polymorphisms in the development of atherosclerosis: a meta-analysis of 18,320 subjects." 01/01/2014 - "Numerous epidemiological studies have evaluated the associations between ATP-binding cassette transporter 1 (ABCA1) R219K (rs2230806) and M883I (rs4149313) polymorphisms and atherosclerosis (AS), but results remain controversial. " 12/01/2023 - "Overall, DOX suppresses the expression of ABCA1 protein by upregulating miR-33, promoting an intracellular lipid deposition in macrophages, which is a sign of early atherosclerosis. "
2.	Coronary Disease (Coronary Heart Disease) 07/01/2005 - "To study the distribution of R219K polymorphism in ATP-Binding Cassette Transporter 1 (ABCA1) gene in Chinese Han population and the association of this polymorphism with coronary heart disease (CHD) . " 07/01/2005 - "[Relationship between the R219K polymorphism of ATP-binding cassette transporter 1 gene and coronary heart disease]." 04/01/2003 - "The association of the R219K polymorphism in the ATP-binding cassette transporter 1 ( ABCA1) gene with coronary heart disease and hyperlipidaemia." 02/15/2001 - "Common variants in the gene encoding ATP-binding cassette transporter 1 in men with low HDL cholesterol levels and coronary heart disease." 04/01/2003 - "The R219K polymorphism in the ATP-binding cassette transporter 1 gene ( ABCA1) has been associated with reduced severity of atherosclerosis, fewer coronary events, decreased triglycerides and a trend to increased HDL in men with coronary heart disease (CHD). "
3.	Hyperthyroidism 07/01/2008 - "Here, we show that severe hyperthyroidism in mice did not affect hepatic expression of scavenger receptor class B, type I, but reduced hepatic expression of ATP-binding cassette transporter 1, accompanied by a 40% reduction of HDL-C. " 07/01/2008 - "The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7alpha-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [(3)H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1."
4.	Cardiovascular Diseases (Cardiovascular Disease) 09/01/2014 - "ATP binding cassette transporter 1 (ABCB1) plays a critical role in the development and progression of cardiovascular disease. " 03/01/2014 - "ATP-binding cassette transporter 1 (ABCB1) plays a critical role in the development and progression of cardiovascular disease. " 03/01/2012 - "Targeting ABCA1 receptor-like property using agonists for ABCA1 protein could become a promising new therapeutic target for increasing ABCA1 function and treating cardiovascular disease. " 12/31/2015 - "These findings first show ABCA1 protein up-regulating activity of active constituents of silymarin and provide new avenues for their further study in the context of cardiovascular disease. "
5.	Neoplasms (Cancer) 02/01/2010 - "Normal human breast tissue, breast cancer cell lines, and 162 tumor samples of patients with primary unilateral invasive breast cancer were analyzed for ABCA3 and ABCA1 protein expression by immunohistochemistry using tissue microarrays. " 09/01/2021 - "In high-fat diet-promoted ccRCC cell line 786-O xenograft model, administration of celastrol (0.25, 0.5, 1.0 mg·kg-1·d-1, for 4 weeks, i.p.) dose-dependently inhibited the tumor growth with upregulated LXRα and ABCA1 protein in tumor tissue. " 09/01/2012 - "In our previous study, we demonstrated that lycopene can inhibit the proliferation of androgen-dependent prostate LNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor gamma (PPARγ)-liver X receptor alpha (LXRα)-ATP-binding cassette transporter 1 (ABCA1) pathway. "

Related Drugs and Biologics

1.	ATP-Binding Cassette Transporters (ABC Transporters)
2.	Triglycerides (Triacylglycerol)
3.	Sterols
4.	Cholesterol 7-alpha-Hydroxylase (Cholesterol 7 alpha Hydroxylase)
5.	Member 1 Subfamily G ATP Binding Cassette Transporter
6.	Cholesterol
7.	Lipids
8.	Messenger RNA (mRNA)
9.	Apolipoprotein A-I (Apolipoprotein A1)
10.	Liver X Receptors