Liver X Receptors

Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. They have important functions in regulating cholesterol homeostasis, ENERGY METABOLISM; INFLAMMATION; and the immune response.

Also Known As:

LXR-Alpha Protein; LXRalpha Protein; LXRbeta Protein; Liver X Receptor; Liver X Receptor Alpha; Liver X Receptor Beta; Liver X Receptor-Alpha; Liver X Receptor-Beta; NR1H2 Protein; NR1H3 Protein; Nuclear Orphan Receptor LXR-Alpha; Nuclear Oxysterol Receptors; Nuclear Receptor Subfamily 1, Group H, Member 2; Nuclear Receptor Subfamily 1, Group H, Member 3; Oxysterols Receptor LXR-Alpha; Oxysterols Receptor LXR-Beta; LXR Alpha Protein; LXR-Alpha, Oxysterols Receptor; LXR-Beta, Oxysterols Receptor; Nuclear Orphan Receptor LXR Alpha; Oxysterol Receptors, Nuclear; Oxysterols Receptor LXR Alpha; Oxysterols Receptor LXR Beta

Networked: 923 relevant articles (21 outcomes, 73 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoplasmic and Nuclear Receptors: 3987
    - Liver X Receptors: 923
  - DNA-Binding Proteins: 2009
    - Liver X Receptors: 923

Experts

1.	Gustafsson, Jan-Åke: 21 articles (01/2022 - 05/2011)
2.	Steffensen, Knut R: 21 articles (11/2021 - 12/2005)
3.	Tontonoz, Peter: 21 articles (01/2018 - 09/2002)
4.	Lobaccaro, Jean-Marc A: 12 articles (12/2020 - 01/2002)
5.	Gustafsson, Jan-Ake: 12 articles (01/2017 - 06/2005)
6.	Baron, Silvère: 10 articles (12/2020 - 07/2009)
7.	Chen, Yuanli: 9 articles (01/2021 - 12/2012)
8.	Duan, Yajun: 9 articles (01/2021 - 12/2012)
9.	Han, Jihong: 9 articles (01/2021 - 12/2012)
10.	Kaul, Deepak: 9 articles (08/2013 - 10/2003)

Related Diseases

1.	Atherosclerosis 02/01/2016 - "Recent studies have shown that activation of liver X receptors (LXRs) attenuates the development of atherosclerosis, not only by regulating lipid metabolism but also by suppressing inflammatory signaling. " 12/01/2011 - "Although animal studies indicate that liver X receptor alpha (LXRα) might influence risk of atherosclerosis, data in humans remain scarce. " 05/01/2008 - "Although a range of studies indicated Liver X receptor (LXR) activation inhibited the development of atherosclerosis in animal models, the mechanism of this effect for LXR agonists has not been fully understood. " 01/01/2023 - "Targeting macrophages in atherosclerosis using nanocarriers loaded with liver X receptor agonists: A narrow review." 01/01/2022 - "Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis."
2.	Neoplasms (Cancer) 07/01/2023 - "Liver X receptors (LXRs) have emerged as novel targets for tumor treatment. " 01/01/2022 - "Consequently, 27-HC promoted EMT, oncogenic transformation, and tumor initiation through activation of liver X receptor. " 01/01/2021 - "Shedding light on the roles of liver X receptors in cancer by using chemical probes." 01/01/2020 - "Novel agonists of the nuclear liver-X-receptor (LXR) are designed to treat metabolic disorders or cancer. " 10/01/2019 - "Liver-X-receptor (LXR) agonists are known to bear anti-tumor activity. "
3.	Memory Disorders (Memory Loss) 05/19/2010 - "Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice." 01/01/2021 - "Although activation of liver X receptors (LXR) with agonists decreases Aβ levels and ameliorates contextual memory deficit, concomitant hypercholesterolemia/hypertriglyceridemia limits their clinical application. "
4.	Non-alcoholic Fatty Liver Disease 06/01/2018 - "This study examined the effects of OXY on in vitro model of NAFLD in hepatocyte by the liver X receptor α (LXRα)-mediated induction of lipogenic genes and in vivo model in mice along with its molecular mechanism. " 01/01/2023 - "Targeting Liver X Receptors for the Treatment of Non-Alcoholic Fatty Liver Disease." 07/01/2019 - "We investigated the expression of NPC1L1 and its correlation with liver X receptor (LXR) expression in peripheral mononuclear (PMN) cells in patients with NAFLD. " 07/01/2019 - "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." 05/01/2019 - "Biological mechanisms and related natural modulators of liver X receptor in nonalcoholic fatty liver disease."
5.	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/01/2021 - "Among NRs, the liver X receptors (LXRs) and farnesoid X receptor (FXR) have been of significance as targets for the treatment of metabolic syndrome-related diseases. " 03/01/2008 - "The liver X receptor alpha (NR1H3) plays numerous roles in metabolic pathways involved in metabolic syndrome. " 03/01/2008 - "Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations." 07/02/2013 - "Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the metabolic syndrome is unclear. " 08/01/2015 - "Kaempferol ameliorates symptoms of metabolic syndrome by regulating activities of liver X receptor-β."

Related Drugs and Biologics

1.	Cholesterol
2.	Peroxisome Proliferator-Activated Receptors (PPAR)
3.	Osteopontin
4.	GW 3965
5.	Triglycerides (Triacylglycerol)
6.	Amyloid (Amyloid Fibrils)
7.	Apolipoproteins E (ApoE)
8.	Retinoid X Receptors (Retinoid X Receptor)
9.	Sterol Regulatory Element Binding Proteins
10.	Cholesterol Ester Transfer Proteins

Related Therapies and Procedures

1.	Mediterranean Diet
2.	Therapeutics
3.	Transplantation
4.	Resuscitation
5.	Radiotherapy