Premature Ejaculation

07/30/2010 - "In four randomized, double-blind, placebo-controlled, multicentre studies of 12-24 weeks' duration, oral dapoxetine 30 or 60 mg (administered as needed) was effective in the treatment of men with premature ejaculation, inducing significantly (p < 0.001) greater improvements from baseline than placebo in the primary efficacy endpoint (mean intravaginal ejaculatory latency time [IELT] or mean average IELT [defined as the average of IELT values over the previous 4 weeks], as measured by the female partner utilizing a stopwatch). "
11/01/2015 - "At the final follow-up visit, the mean intravaginal ejaculatory latency time (an increase of 3.4 min) and mean score of Premature Ejaculation Diagnostic Tool (a decrease of -5.0) improved significantly from baseline, and the satisfaction rate and response rate to dapoxetine treatment were 45.0% and 74.6%, respectively. "
09/01/2006 - "Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal."
09/09/2006 - "On-demand dapoxetine is an effective and generally well tolerated treatment for men with moderate-to-severe premature ejaculation."
07/01/2015 - "It is not known whether the efficacy of dapoxetine, the only drug approved for the on-demand treatment of premature ejaculation (PE), can be increased by the addition of sexual behavioral treatment (SBTx). "

11/01/2019 - "Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation? "
12/01/2019 - "Premature ejaculation (PE) is a common sexual dysfunction for which selective serotonin reuptake inhibitors (SSRIs) have been used effectively for treatment. "
01/01/2005 - "Recently, the idea has emerged that on-demand use of serotonin reuptake inhibitors (SSRIs), particularly short half-life, should be equally effective in delaying ejaculation as daily SSRI treatment of premature ejaculation. "
12/01/2017 - "Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses."
02/01/1999 - "Sexual side effects of SSRIs should not be viewed as entirely negative; some studies have shown improved control of premature ejaculation in men. "

01/01/1999 - "These findings suggest that fluoxetine is effective treatment for premature ejaculation probably due to its effect of increasing the penile sensory threshold, without changing the amplitudes and latencies of sacral evoked response and cortical somatosensory evoked potential."
10/01/1996 - "We hypothesized that the SSRI fluoxetine might be effective in treating premature ejaculation. "
07/01/2003 - "In men with premature ejaculation 90 mg fluoxetine weekly may be regarded as an effective and safe treatment."
11/01/1996 - "Fluoxetine may be regarded as a safe and effective alternative in the treatment of premature ejaculation."
11/01/1996 - "The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study."

02/01/2014 - "This study aimed at evaluating the safety and efficacy of an improved dosage regimen of sertraline in patients with premature ejaculation (PE) and to examine whether the premature ejaculation diagnostic tool (PEDT) can be used as a measure of treatment response in these patients. "
02/01/2014 - "An improved dosage regimen of sertraline hydrochloride in the treatment for premature ejaculation: an 8-week, single-blind, randomized controlled study followed by a 4-week, open-label extension study."
11/01/2006 - "Efficacy of sertraline hydrochloride in treatment of premature ejaculation: a placebo-controlled study using a validated questionnaire."
02/01/2023 - "Clinical value of penile sympathetic skin response to assess the efficacy of sertraline in the treatment of patients with sympathetic hyperexcitability in primary premature ejaculation."
11/01/2015 - "[Efficacy of Shugan Yiyang Capsules combined with sertraline on premature ejaculation]."

04/01/2007 - "Recently, sildenafil has been demonstrated to be effective in treating premature ejaculation (PE). "
06/01/2003 - "Although controlled studies are needed to evaluate the efficacy of erection-enhancing drugs in premature ejaculation, it is possible that sildenafil might be useful for this indication."
06/01/2006 - "Future studies may support an in vivo effect of sildenafil for delaying or inhibiting seminal vesicle emission, thereby, promoting improvement in patients with premature ejaculation."
05/01/2004 - "To study the efficacy of Viagra combined with behavior therapy against premature ejaculation (PE). "
05/01/2005 - "Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation."

01/01/2017 - "Recently it was shown that tramadol is also effective in human premature ejaculation. "
03/01/2022 - "Notice of Retraction: Safety and Efficacy of Tramadol in the Treatment of Premature Ejaculation: A Double-blind, Placebo-Controlled, Fixed-Dose, Randomized Study."
01/01/2013 - "All studies evaluating the efficacy of tramadol for the treatment of PE published in peer reviewed medical journals between 2006 and March 2012 were identified by searching for the keywords "premature ejaculation" and "tramadol" in the PubMed database. "
02/01/2006 - "Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study."
09/01/2021 - "Safety and efficacy of "on-demand" tramadol in patients with premature ejaculation: an updated meta-analysis."

10/01/2011 - "To validate the therapeutic efficacy of paroxetine in the treatment of premature ejaculation (PE). "
08/25/2015 - "Improvement in serum 5-HT concentrations has obvious association with primary premature ejaculation symptom improvement with paroxetine use."
08/25/2015 - "Association Between Changes in Serum 5-Hydroxy-Tryptamine Concentrations and Improvement in Clinical Symptoms in Primary Premature Ejaculation with Paroxetine Treatment."
10/01/1999 - "To evaluate the efficacy of chronic and 'on demand' administration of paroxetine hydrochloride in the drug treatment of premature ejaculation (PE). "
06/01/1999 - "We evaluate the efficacy of paroxetine hydrochloride as needed for the treatment of premature ejaculation. "

02/01/2006 - "The use of topical EMLA-cream-only seems to be an effective treatment of premature ejaculation."
12/01/2002 - "Therefore, lidocaine-prilocaine cream 5% is effective in premature ejaculation and 20 min of application time before sexual contact is the optimum period."
10/01/1995 - "We evaluated the efficacy of a new lidocaine-prilocaine cream in preventing premature ejaculation. "
09/01/2010 - "Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study."
11/01/1996 - "Re: Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation."

03/01/2006 - "Safety and efficacy of citalopram in the treatment of premature ejaculation: a double-blind placebo-controlled, fixed dose, randomized study."
12/01/2002 - "In the present study, we decided to examine the efficacy of citalopram, an SSRI, in the treatment of premature ejaculation. "
12/01/2002 - "The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study."
12/01/2012 - "[Efficacy of citalopram on premature ejaculation: a clinical observation]."
12/01/2012 - "We included in this study 80 patients who came to our andrological clinic for premature ejaculation from May 2011 to May 2012, and randomly assigned them to a treatment and a control group of equal number to receive citalopram (20 mg/d) and placebo, respectively. "

02/01/2021 - "Clomipramine is effective in treating premature ejaculation, a common form of male sexual dysfunction that affects individual's mental health and quality of life, but its optimal dosage remains controversial. "
01/01/2019 - "The results of this multicenter, randomized, double-blind, placebo controlled, fixed dose clinical phase III study suggest that administering clomipramine 15 mg on demand to treat premature ejaculation is effective and safe."
01/01/1993 - "These findings suggest that low dose clomipramine may be useful in the treatment of premature ejaculation."
01/01/2019 - "The aim of the current trial was to assess the efficacy of on demand clomipramine 15 mg administered before sexual intercourse for the treatment of premature ejaculation. "
04/01/2018 - "To evaluate the adequate therapeutic dosage of clomipramine 15 mg/day and clomipramine 30 mg/day in male patients with premature ejaculation (PE), this study enrolled men aged 20-65 years who met diagnostic criteria for PE including Intravaginal Ejaculation Latency Time (IELT) less than 2 min for at least 75% of their sexual intercourses. "

11/01/2006 - "This article describes the diagnosis and treatment of premature ejaculation (PE) from a sex therapist's perspective and proposes that combination therapy integrating sex therapy and sexual pharmaceuticals is frequently the best treatment approach. "
01/01/2019 - "As an effective treatment for premature ejaculation is a behavioral therapy and is widely used worldwide. "
06/30/2014 - " therapy, necessitates a fairly long period of time (2-6 months) and a great commitment on the part of the patient, nevertheless it can be a valid and effective treatment for patients with premature ejaculation. "
07/01/2020 - "Editorial Comment: Novel Treatment for Premature Ejaculation in the Light of Cur-rently Used Therapies: A Review."
01/01/2019 - "Novel treatment for premature ejaculation in the light of currently used therapies: A review. "

01/01/2019 - " novel inner condom using ADM is an effective and safe surgical treatment for males with premature ejaculation. "
02/01/2022 - "This study aimed to evaluate the efficacy of thickened condoms in the treatment of premature ejaculation. "
02/01/2022 - "Thickened condoms physically preserve and extend the time of penile erection, resist and overcome premature ejaculation, and improve the ejaculation condition to improve the quality of sexual intercourse."
02/01/2022 - "After using a thickened condom, the time to ejaculate of the premature ejaculation group was significantly prolonged (P<0.05). "
02/01/2022 - "The comfortability associated with thickened condoms in the premature ejaculation group was poor (P<0.05). "

05/01/2021 - "The premature ejaculation diagnostic values and sexual partner satisfaction had significantly improved after treatment. "
01/01/1996 - "Further controlled and larger studies that focus on clinically relevant issues such as dose, length of treatment, maintenance of beneficial effects after treatment discontinuation, and the combination of pharmaco- and behavior therapy for premature ejaculation are warranted. "
02/01/2023 - "Changes in intravaginal ejaculation latency time (IELT), Premature Ejaculation Diagnostic Tool, International Index of Erectile Function (IIEF-5), and PSSR latency and wave amplitude were compared before and after treatment. "
01/01/2023 - "Outcomes included changes in IELT and Premature Ejaculation Profile before and after treatment, last visit Clinical Global Impression of Change scores, and vPatch safety profile. "
01/01/2021 - "Patients were evaluated with the Arabic Index of Premature Ejaculation (AIPE) scores, intravaginal ejaculatory latency times (IELTs), and frequency of sexual intercourse before and after treatments. "

07/01/2020 - "To study the medication rules of traditional Chinese medicine (TCM) in the treatment of premature ejaculation. "
06/01/2022 - "To investigate the correlation between the characteristics of resting-state brain function and the types of traditional Chinese medicine (TCM) syndrome in premature ejaculation (PE) patients with heart-kidney disharmony, and the pathogenesis of abnormal ejaculation of the patients. "
07/01/2020 - "[Medication rules of traditional Chinese medicine for the treatment of premature ejaculation: An analysis based on data mining]."
01/01/2020 - "Qiaoshao (QS) formula, a traditional Chinese medicine (TCM) comprising seven herbs, has been clinically proven to have a favorable treatment effect on premature ejaculation (PE). "
05/01/2019 - "This systematic review will evaluate the efficacy and safety of Traditional Chinese medicine for treating premature ejaculation. "

02/01/2009 - "Selective neurectomy of the dorsal penile nerve is safe and effective for the treatment of primary premature ejaculation."
03/01/2016 - "[Comparing efficacy of selective penile denervation and circumcision for primary premature ejaculation]."
08/01/2022 - "The use of selective dorsal neurectomy (SDN) as a surgical treatment of premature ejaculation (PE) has increased for many years in Asian countries. "
08/01/2022 - "Correlation between age and curative effects of selective dorsal neurectomy for primary premature ejaculation."
09/01/2019 - "We report 1 case of microsurgical denervation of penis in men with lifelong premature ejaculation after failing to be treated conservatively. "