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Sertraline (Zoloft)

A selective serotonin uptake inhibitor that is used in the treatment of depression.

Also Known As:

Zoloft; Lustral; Gladem; Altruline; Apo-Sertraline; Apotex Brand of Sertraline Hydrochloride; Aremis; Besitran; Boehringer Ingelheim Brand of Sertraline Hydrochloride; Esteve Brand of Sertraline Hydrochloride; Gen-Sertraline; Genpharm Brand of Sertraline Hydrochloride; Lacer Brand of Sertraline Hydrochloride; Novo-Sertraline; Novopharm Brand of Sertraline Hydrochloride; Parke Davis Brand of Sertraline Hydrochloride; Pfizer Brand of Sertraline Hydrochloride; Ratiopharm Brand of Sertraline Hydrochloride; Rhoxal-sertraline; Rhoxalpharma Brand of Sertraline Hydrochloride; Roerig Brand of Sertraline Hydrochloride; Sealdin; Sertraline Hydrochloride; Sertraline Hydrochloride (1S-cis)-Isomer; ratio-Sertraline; Apo Sertraline; Gen Sertraline; Hydrochloride, Sertraline; Novo Sertraline; Rhoxal sertraline; ratio Sertraline; 1-Naphthalenamine,1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-

Networked: 1161 relevant articles (220 outcomes, 331 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Feeny, Norah C: 12 articles (10/2015 - 08/2003)
2.	Zoellner, Lori A: 12 articles (10/2015 - 08/2003)
3.	O'Connor, Christopher M: 10 articles (09/2015 - 08/2002)
4.	Clary, Cathryn M: 10 articles (06/2007 - 01/2002)
5.	Lyketsos, Constantine G: 9 articles (01/2014 - 07/2003)
6.	Jiang, Wei: 8 articles (09/2015 - 07/2007)
7.	Compton, Scott N: 8 articles (05/2015 - 12/2008)
8.	Birmaher, Boris: 8 articles (03/2015 - 12/2008)
9.	Rabins, Peter V: 8 articles (01/2014 - 07/2003)
10.	Davidson, Jonathan R T: 8 articles (04/2008 - 01/2004)

Related Diseases

1.	Post-Traumatic Stress Disorders (PTSD) 10/01/2011 - "Unlike civilian post-traumatic stress disorder (PTSD), the efficacy of sertraline for the treatment of combat-related PTSD has not yet been proven. " 05/01/2001 - "The results of the current study suggest that sertraline is a safe, well-tolerated, and significantly effective treatment for PTSD." 04/01/2015 - "Clinically significant reductions in both PTSD and AUD severity were achieved and sustained through 12-months follow-up, Moreover, greater mean improvement in PTSD symptoms was observed across all follow-up assessments in the SS plus sertraline group. " 04/01/2015 - "The SS plus sertraline group exhibited a significantly greater reduction in PTSD symptoms than the SS plus placebo group at end-of-treatment (M difference = -16.15, p = .04, d = 0.83), which was sustained at 6- and 12-month follow-up (M difference = -13.81, p = .04, d = 0.71, and M difference = -12.72, p = .05, d = 0.65, respectively). " 07/01/2007 - "Both groups experienced significant improvement in posttraumatic stress disorder and other clinical outcomes from pre- to posttreatment with no significant group x time differences between groups except in Child Global Assessment Scale ratings, which favored the TF-CBT + sertraline group. "
2.	Major Depressive Disorder (Major Depressive Disorders) 01/01/2002 - "Results from several well designed trials show that sertraline (50-200 mg/day) is effective in the treatment of major depressive disorder in elderly patients (> or =60 years of age). " 01/01/2002 - "Results from several well designed trials show that sertraline (50 to 200 mg/day) is effective in the treatment of major depressive disorder in elderly patients (> or =60 years of age). " 03/01/2009 - "In non-comorbid patients, sertraline is effective for the acute treatment of major depressive disorders and prevention of relapse or recurrence. " 03/01/2005 - "Sertraline is the only treatment for major depressive disorder studied in a placebo-controlled trial of patients with ACS and found to be safe and effective. " 01/01/2011 - "Placeboxetine is as safe and effective as sertraline in Indian patients with major depressive disorder."
3.	Anxiety Disorders (Anxiety Disorder) 11/01/2003 - "With its beneficial side-effect profile and proven efficacy in social anxiety disorder, sertraline can be considered a valuable addition to the variety of treatments currently available for this disorder." 09/01/2003 - "Patients treated with sertraline improved significantly (P <.05) compared to placebo on both the CAPS-2 and DTS whether or not they had a comorbid depressive or anxiety disorder. " 05/01/2001 - "In open treatment, sertraline resulted in significant improvement in symptoms of childhood social anxiety disorder. " 05/01/2009 - "Combination of cognitive behavioral therapy and sertraline is more effective than monotherapy for pediatric anxiety disorders." 12/25/2008 - "Both cognitive behavioral therapy and sertraline reduced the severity of anxiety in children with anxiety disorders; a combination of the two therapies had a superior response rate. "
4.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 02/01/2007 - "Group cognitive behavioural therapy increases complete remission of obsessive-compulsive disorder symptoms compared with sertraline, but not response." 11/01/2005 - "Both GCBT and sertraline conditions had significant improvement in obsessive-compulsive disorder symptoms as measured by the Children's Yale-Brown Obsessive-Compulsive Scale after 12 weeks of treatment. " 01/01/1995 - "Studies have also shown sertraline to be effective in obsessive-compulsive disorder. " 11/01/2005 - "The treatment with GCBT may be effective in decreasing obsessive-compulsive symptoms in childhood obsessive-compulsive disorder and should be considered as an alternative to either individual cognitive-behavioral therapy or a medication, such as sertraline. " 10/01/1992 - "Additionally, sertraline is the only antidepressant licensed in the UK for the prevention of recurrence of depression, and preliminary findings suggest that the drug may also be effective in the treatment of obsessive-compulsive disorder. "
5.	Panic Disorder (Panic Attack) 05/01/2000 - "Although numerous studies have found sertraline to be very effective in the treatment of anxiety, there have been few case reports of panic attacks actually being induced by treatment with sertraline. " 01/01/1998 - "This suggests that the NIMH Consensus Conference played a key role in developing successful multicenter pharmacological treatment studies, such as this one that ultimately demonstrated that sertraline was an effective treatment for panic disorder." 11/01/1998 - "Sertraline-treated patients exhibited significantly greater improvement (P=.01) at end point than did patients treated with placebo for the primary outcome variable, panic attack frequency. " 09/01/1998 - "Sertraline was significantly more effective than placebo in decreasing the number of full and limited-symptom panic attacks. " 01/01/1998 - "Patients with panic disorder who were treated with sertraline had a statistically significant reduction in the mean number of panic attacks per week (the primary efficacy measure) as compared with placebo (4.8 vs. 2.5, p < .001). "

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Fluoxetine (Prozac)
3.	Paroxetine (Paxil)
4.	Citalopram (Escitalopram)
5.	venlafaxine (Effexor)
6.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)
7.	Fluvoxamine (Luvox)
8.	Antidepressive Agents (Antidepressants)
9.	Bupropion (Wellbutrin)
10.	Imipramine (Janimine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Phototherapy (Light Therapy)
3.	Sympathectomy (Sympathectomies)
4.	Palliative Care (Palliative Medicine)
5.	Aftercare (After-Treatment)