Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation? A randomized clinical trial.

Abstract

PURPOSE:

To compare the efficacy and safety of available selective serotonin reuptake inhibi-tors (SSRIs) in order to find the most effective drug with the least number of side effects in treatment of premature ejaculation (PE).

MATERIALS AND METHODS:

This study was a randomized clinical trial. Four hundred and eighty pati-ents with PE in the 4 groups referred to Imam Reza hospital Tehran, Iran from July 2018 to Fe-bruary 2019 were enrolled in the study. The patients received sertraline 50mg, fluoxetine 20mg, paroxetine 20mg and citalopram 20mg, every 12 hours daily. The intravaginal ejaculatory laten-cy time (IELT) before treatment, fourth and eighth weeks after treatment was recorded by the patient's wife with a stopwatch.

RESULTS:

Mean IELT before, 4 and 8 weeks after treatment in four groups were: sertraline 69.4±54.3, 353.5±190.4, 376.3±143.5; fluoxetine 75.5±64.3, 255.4±168.2, 314.8±190.4; paroxeti-ne 71.5±69.1, 320.7±198.3, 379.9±154.3; citalopram 90.39±79.3, 279.9±192.1, 282.5±171.1 seconds, respectively. The ejaculation time significantly increased in all groups (p <0.05), but there was no significant difference between the groups (P=0.75). Also, there was no significant difference in drugs side effects between groups (p >0.05). The most common side effects were drowsiness and dyspepsia, which were not severe enough to cause discontinuation of the drug.

CONCLUSIONS:

All available SSRIs were effective and usually had no serious complications. In patients who did not respond to any of these drugs, other SSRI drugs could be used as a salvage therapy.

• Authors: Soheila Siroosbakht, Sadra Rezakhaniha, Bijan Rezakhaniha
• Journal: International braz j urol : official journal of the Brazilian Society of Urology (Int Braz J Urol) 2019 Nov-Dec Vol. 45 Issue 6 Pg. 1209-1215 ISSN: 1677-6119 [Electronic] Brazil
• PMID: 31808410 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright® by the International Brazilian Journal of Urology.

Chemical References

• Serotonin Uptake Inhibitors
• Fluoxetine
• Citalopram
• Paroxetine
• Sertraline

Topics

• Adult
• Aged
• Citalopram (therapeutic use)
• Ejaculation (drug effects)
• Fluoxetine (therapeutic use)
• Humans
• Male
• Middle Aged
• Paroxetine (therapeutic use)
• Premature Ejaculation (drug therapy)
• Reaction Time (drug effects)
• Selective Serotonin Reuptake Inhibitors (therapeutic use)
• Sertraline (therapeutic use)
• Time Factors
• Treatment Outcome
• Young Adult