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Fluoxetine (Prozac)

The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

Also Known As:

Prozac; Sarafem; Fluoxetin; Fluoxetine Hydrochloride; Lilly-110140; N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine; Lilly 110140; Lilly110140; Benzenepropanamine, N-methyl-gamma-(4-(trifluoromethyl)phenoxy)-, (+-)-

Networked: 2546 relevant articles (330 outcomes, 646 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Propylamines
    - Fluoxetine: 2546

Experts

1.	Fava, Maurizio: 49 articles (06/2012 - 01/2002)
2.	Papakostas, George I: 23 articles (06/2012 - 07/2002)
3.	Nierenberg, Andrew A: 22 articles (06/2012 - 01/2002)
4.	Thase, Michael E: 20 articles (12/2014 - 05/2003)
5.	Alpert, Jonathan E: 18 articles (06/2012 - 01/2002)
6.	Mischoulon, David: 15 articles (06/2012 - 12/2002)
7.	Emslie, Graham J: 13 articles (12/2015 - 10/2002)
8.	Petersen, Timothy: 13 articles (01/2007 - 01/2002)
9.	Rosenbaum, Jerrold F: 13 articles (01/2007 - 01/2002)
10.	Vitiello, Benedetto: 12 articles (10/2009 - 08/2004)

Related Diseases

1.	Major Depressive Disorder (Major Depressive Disorders) 04/01/2005 - "Fluoxetine plus cognitive behavioural therapy was most effective for adolescents with major depressive disorder." 10/01/1986 - "A 6-week double-blind trial of fluoxetine treatment of unipolar major depressive disorder in 49 patients was evaluated in terms of improvement in the Hamilton Depression Rating Scale (HDRS) and Clinical Global Improvement (CGI) scores. " 04/01/2001 - "The results of that double-blind, placebo-controlled study suggest that fluoxetine was effective in decreasing but not eliminating both the depressive symptoms (including suicidal ideations) and the level of alcohol consumption among a study group of subjects with comorbid major depressive disorder and alcohol dependence, many of whom displayed suicidal ideations. " 08/01/1997 - "Fluoxetine is effective in reducing the depressive symptoms and the alcohol consumption of patients with comorbid major depressive disorder and alcohol dependence. " 07/01/2004 - "The efficacy of fluoxetine is now well established in the treatment of major depressive disorder. "
2.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 08/01/1990 - "Fluoxetine 60 mg/day resulted in complete remission of the pathologic jealousy, consistent with the known efficacy of fluoxetine in obsessive compulsive disorder." 07/01/1989 - "A 12-week open trial of fluoxetine in 61 obsessive-compulsive disorder patients significantly improved depressive and obsessive-compulsive symptoms. " 06/01/1998 - "Fluoxetine is effective in treating obsessive-compulsive disorder (OCD). " 04/01/1991 - "Therapeutic benefit may have been related to the efficacy of fluoxetine in the treatment of obsessive compulsive disorders or to direct effects on sexual activity, or both." 11/01/1990 - "This study suggests that fluoxetine is an effective and safe treatment for obsessive-compulsive disorder, both for short-term alleviation and for long-term maintenance."
3.	Panic Disorder (Panic Attack) 05/01/1999 - "Fluoxetine at doses ranging from 10 to 60 mg administered once weekly appears to be effective maintenance treatment for patients with panic disorder who were initially treated successfully with daily fluoxetine. " 03/01/1999 - "To assess the safety and efficacy of continued fluoxetine treatment following successful acute therapy of panic disorder. " 11/01/1998 - "The authors studied the efficacy of fluoxetine treatment in panic disorder and measured the relative contributions of changes in symptoms to overall improvement. " 11/01/1993 - "Recent reports suggest that fluoxetine in doses less than the standard 20 mg/day may be effective in the treatment of depression and that some patients, particularly those with panic disorder, may be intolerant of the 20 mg/day dose. " 10/01/1987 - "Fluoxetine may be effective in the treatment of panic attacks, perhaps implicating the serotonergic system in the pathophysiology of panic disorder. "
4.	Depressive Disorder (Melancholia) 11/01/2011 - "The improvement in cellular oxidative status may be an important mechanism underlying the protective pharmacological effects of fluoxetine, which are clinically observed in the treatment of depressive disorders." 01/01/1993 - "Fluoxetine was statistically significantly superior to placebo in patients with melancholia (endpoint change in the Montgomery-Asberg Depression Rating Scale [MADRS] score, response rates and remission rates). " 01/01/2008 - "Acupuncture is an effective and safe therapy for depressive neurosis; therapeutic effect of acupuncture on depressive neurosis possibly is better than or similar to that of Prozac, but with less side-effects." 04/18/2002 - "By contrast, in only one placebo-controlled study fluoxetine (SSRI) has shown to be effective in the treatment of depressive disorders in these age groups. " 03/01/2000 - "To get an impression of the efficacy of the widely used phytopharmaceutical St. John's wort, the antidepressant efficacy in mild depressive disorders was compared with that of the standard antidepressant fluoxetine. "
5.	Post-Traumatic Stress Disorders (PTSD) 07/01/1999 - "To demonstrate that fluoxetine is more effective than placebo in treating PTSD. " 01/01/2000 - "Smaller double-blind, placebo-controlled trials have also indicated that fluoxetine is an effective treatment for PTSD. " 07/01/2011 - "Findings suggest that fluoxetine is an effective treatment for PTSD, with mild adverse effects on individuals." 04/01/1993 - "The efficacy of fluoxetine for some PTSD patients is interesting in light of emerging neuropharmacologic data suggesting serotonergic dysregulation in some PTSD patients. " 04/01/2007 - "Failed efficacy of fluoxetine in the treatment of posttraumatic stress disorder: results of a fixed-dose, placebo-controlled study."

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Sertraline (Zoloft)
3.	venlafaxine (Effexor)
4.	Paroxetine (Paxil)
5.	olanzapine (Zyprexa)
6.	Fluvoxamine (Luvox)
7.	Antidepressive Agents (Antidepressants)
8.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)
9.	Clomipramine (Anafranil)
10.	Citalopram (Escitalopram)

Related Therapies and Procedures

1.	Oral Administration
2.	Drug Therapy (Chemotherapy)
3.	Renal Dialysis (Hemodialysis)
4.	Phototherapy (Light Therapy)
5.	Ligation