[Comparing efficacy of selective penile denervation and circumcision for primary premature ejaculation].

Abstract

OBJECTIVE:

To compare the efficacy and safety of selective penile denervation to that of circumcision for primary premature ejaculation (PPE).

MATERIALS AND METHODS:

A prospective study comprised 138 patients with PPE, divided into two groups. Patients in Group 1 (n=50) underwent selective penile denervation by dissecting about a half of dorsal penile nerve branches. Large nerves (> 2 mm) were subjected to microsurgical neurorrhaphy. In group 2 (n=88) circumcision was carried out using guillotine technique. The evaluation of treatment efficacy was carried out using the Criteria for premature ejaculation questionnaire (CriPE), measuring intravaginal ejaculation latency time (IELT) with a stopwatch and testing penile vibration sensitivity. These examinations were performed at baseline and after 2, 4, 6, 8, 10 and 12 months after operation.

RESULTS:

By the end of follow-up, 88% and 10.2% of patients of group 1 and group 2 had no signs of PPE, respectively. At 12 months IELT index increased 6-fold in patients of group 1 from 53,6+/-12,7 to 335,6+/-81,5 seconds, while remaining unchanged in group 2 with 51,8+/-10,4 seconds at baseline and 53.9+/-20.1 seconds at the end of follow-up. Group 1 showed statistically significant and sustained reduction in penile vibration sensitivity compared with baseline (p<0,001). In group 2, the baseline and endpoint characteristics of bio-tensiometry did not differ significantly (p>0,05).

CONCLUSIONS:

The resulting effectiveness of selective penile denervation and circumcision for PPE was 88% and 10.2%, respectively, with comparable safety.

• Authors: Yu G Alyaev, N D Akhvlediani
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) Issue 1 Suppl 1 Pg. 60-64 (Mar 2016) ISSN: 1728-2985 [Print] Russia (Federation)
• PMID: 28247749 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Circumcision, Male
• Denervation
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Premature Ejaculation (physiopathology, surgery)