Graft Pancreatitis

An inflammatory disease and serious complication of PANCREAS TRANSPLANTATION. It is caused by a premature activation of pancreatic proenzymes leading to autodigestion of the gland and can be attributed to immunological or nonimmunological causes.

Also Known As:

Networked: 73 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Pancreatic Fistula (Pancreatic Fistulas)
3.	Thrombosis (Thrombus)
4.	Reperfusion Injury
5.	Ischemia

Experts

1.	Benz, S: 5 articles (11/2004 - 03/2001)
2.	Hopt, U T: 5 articles (11/2004 - 03/2001)
3.	Nazarewski, S: 4 articles (10/2011 - 09/2003)
4.	Szmidt, J: 4 articles (10/2011 - 09/2003)
5.	Grochowiecki, T: 4 articles (10/2011 - 09/2003)
6.	Obermaier, R: 4 articles (11/2004 - 03/2001)
7.	Jakimowicz, T: 3 articles (10/2011 - 09/2003)
8.	Gebhard, Martha-Maria: 3 articles (03/2006 - 07/2003)
9.	Wojtaszek, M: 3 articles (01/2006 - 09/2003)
10.	Frunze, S: 2 articles (10/2011 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Graft Pancreatitis:

1.	C-Reactive ProteinIBA 08/01/2003 - "Prophylactic treatment with ET(A)-RA significantly reduced the severity of graft pancreatitis evidenced by C-reactive protein. " 03/27/2001 - "The degree of graft pancreatitis was assessed by peak-C-reactive protein (CRP) defined as highest CRP within 3 days after transplantation. "
2.	AmylasesFDA Link 10/01/1997 - "It is particularly difficult to distinguish between early rejection and graft pancreatitis when early rejection produces an elevated serum amylase level. " 01/01/1986 - "Although cold ischemia time was kept low in this series, a moderate graft pancreatitis developed, with a peak serum amylase level of 16.8 + 2.2 ukat/l and a peak amylase activity in the peripancreatic fluid of 280 + 110 ukat/l. " 05/01/1987 - "Although graft cold ischemia time was kept low (a mean of 4.6 hours), a moderate graft pancreatitis developed with a peak serum amylase level of 16.8 +/- 2.2 microkatal per liter. " 01/01/1989 - "In the pancreas transplant patients, PASP and amylase levels were elevated in episodes of graft pancreatitis. "
3.	Insulin (Novolin)FDA Link 03/01/1991 - "All patients were immediately insulin independent, and there were no cases of initial nonfunction or graft pancreatitis. " 04/15/1995 - "Following simultaneous pancreas-kidney transplantation (n = 6), all patients were insulin independent and free of graft pancreatitis; one patient required hemodialysis (16.7%). " 09/01/2008 - "In reviewing our experiences, we found in pancreata flushed with HTK a higher incidence of postoperative complications including graft pancreatitis, use of octreotide and a decreased rate of insulin-independence at hospital discharge. "
4.	Endothelin A ReceptorIBA 08/01/2003 - "The effect of prophylactic administration of a selective endothelin(A) receptor antagonist (ET(A)-RA) on ischemia/reperfusion injury in an experimental model of graft pancreatitis after pancreas transplantation was evaluated. " 11/01/2001 - "Protective effect of a selective endothelin a receptor antagonist (BSF 208075) on graft pancreatitis in pig pancreas transplantation."
5.	Octreotide (Sandostatin)FDA LinkGeneric 06/01/1996 - "Octreotide effects on pancreatic graft pancreatitis in inbred pigs." 09/01/2008 - "In reviewing our experiences, we found in pancreata flushed with HTK a higher incidence of postoperative complications including graft pancreatitis, use of octreotide and a decreased rate of insulin-independence at hospital discharge. "
6.	Bretschneider cardioplegic solutionIBA 05/01/2009 - "We observed and reported increased graft pancreatitis in pancreata flushed with HTK solution, which prompted this review of transplanting HTK-flushed kidneys. " 02/01/2010 - "Recent reports suggested that pancreas preservation with histidine-tryptophan-ketoglutarate solution (HTK) might be a risk factor for reperfusion pancreatitis, graft thrombosis and decreased short- and long-term graft survival. "
7.	Heme Oxygenase-1IBA 12/27/2007 - "The role of heme oxygenase-1 (HO-1) in pancreas transplantation and prevention of graft pancreatitis is unknown. "
8.	Carboxypeptidase BIBA 10/01/1995 - "After perfusion with Perfadex and cold ischemia for 24 h, but prior to reperfusion, activated carboxypeptidase B was demonstrated in tissue samples from the graft parenchyma with a Western blot technique, indicating that graft pancreatitis may already be initiated during the preservation phase. "
9.	Nitric Oxide Synthase (NO Synthase)IBA 10/01/2010 - "Depletion of the nitric oxide synthase cofactor tetrahydrobiopterin (H4B) during ischemia and reperfusion is associated with severe graft pancreatitis. "
10.	TrypsinIBA 01/01/1992 - "Graft pancreatitis and allograft rejection were both accompanied by increased serum levels of immunoreactive anionic trypsin (irAT) in a porcine pancreatic allograft transplantation model. " 01/01/1992 - "Characterization of immunoreactive trypsin as a means of differentiating graft pancreatitis and allograft rejection after porcine pancreatic transplantation." 01/01/1992 - "During graft pancreatitis, a major part of the immunoreactivity was found within the high-molecular-weight fraction corresponding to the formation of complexes between trypsin and protease inhibitors. "

Therapies and Procedures

1.	Transplants (Transplant) 10/01/2006 - "The oxidative injury of a pancreatic graft preserved for 18 or 24 hours occurs during reperfusion, with an extraordinary intensity, but similarly with CS and UW, an observation that may help to explain graft pancreatitis." 10/01/2015 - "Incidence and Histologic Features of Transplant Graft Pancreatitis: A Single Center Experience." 10/01/2011 - "Among the SPpreKT group, the most severe complication was graft pancreatitis leading to graft removal in 2 recipients. " 09/01/2009 - "Peripancreatic fluid collections are among the common post pancreas transplant complications, which are mainly due to leakage from the anastomosis site to bowel and graft pancreatitis. " 03/01/2009 - "The pancreas graft was removed due to recurrent graft pancreatitis of unknown cause. "
2.	Kidney Transplantation 09/01/2003 - "The aim of this study was to evaluate the influence of pretransplant serum lipid levels on the development of graft pancreatitis among patients undergoing simultaneous pancreas and kidney transplantation (spkTx). " 06/01/2008 - "Acute graft pancreatitis is a frequent late complication after simultaneous pancreas-kidney transplantation (SPKT) with enteric drainage that is not well understood. " 10/01/2006 - "In addition, antithrombin has recently been clinically used to reduce graft pancreatitis after pancreas-kidney transplantation, and to improve kidney perfusion. " 11/01/1993 - "Native and graft pancreatitis following combined pancreas-renal transplantation." 01/01/1998 - "The most likely cause of graft pancreatitis is the ischemia/reperfusion injury which can be a major problem in simultaneous pancreas-kidney transplantation. "
3.	Homologous Transplantation (Allograft) 10/01/2002 - "Recurrent graft pancreatitis in a pancreatico-renal allograft recipient does not affect endocrine function." 03/01/1992 - "Early postoperative graft pancreatitis of the bladder drained pancreatic allografts remains a significant problem. " 10/01/1997 - "This study included five groups: allografts without immunosuppression (group A, n = 12), allografts with immunosuppression (group B, n = 13), autografts without immunosuppression (group C, n = 11), autografts with immunosuppression (group D, n = 12), and autografts treated by 45 minutes of pretransplant warm ischemia to induce acute graft pancreatitis (group E, n = 14). " 07/01/2000 - "Complications of the pancreas allograft included graft pancreatitis and sepsis, leading to a poor kidney outcome with sub-optimal kidney function at 1 year. " 10/01/2015 - "This case series demonstrates that 61% of rejected allografts over a span of 13 years at a single center had histologic features of graft pancreatitis, suggesting that pancreatitis may be a contributory mechanism to graft failure."
4.	Warm Ischemia 10/01/1997 - "This study included five groups: allografts without immunosuppression (group A, n = 12), allografts with immunosuppression (group B, n = 13), autografts without immunosuppression (group C, n = 11), autografts with immunosuppression (group D, n = 12), and autografts treated by 45 minutes of pretransplant warm ischemia to induce acute graft pancreatitis (group E, n = 14). "
5.	Pancreas Transplantation 02/01/2013 - "Graft pancreatitis is the second most-frequent complication following pancreas transplantation. " 01/01/2007 - "In clinical pancreas transplantation the choice of preservation solution may have an impact on graft pancreatitis. " 01/01/2005 - "Graft pancreatitis is a major complication after pancreas transplantation. " 09/01/2003 - "Graft pancreatitis is a serious complication following pancreas transplantation. " 03/27/2001 - "Impairment of microcirculation in the early reperfusion period predicts the degree of graft pancreatitis in clinical pancreas transplantation."