Do high levels of serum triglycerides in pancreas graft recipients before transplantation promote graft pancreatitis?

Abstract

OBJECTIVE:

Graft pancreatitis is a serious complication following pancreas transplantation. The aim of this study was to evaluate the influence of pretransplant serum lipid levels on the development of graft pancreatitis among patients undergoing simultaneous pancreas and kidney transplantation (spkTx).

METHODS:

We reviewed data from spkTx patients engrafted between 1999 and 2002. Group 1 consisted of 10 recipients with well-established pancreas and kidney graft function without postoperative pancreatitis; group 2 5 spkTx recipients who developed fatal graft pancreatitis in the first posttransplant month. The lipid parameters evaluated within 1 hour before transplantation and after hemodialysis included total cholesterol, HDL, LDL, VLDL, triglicerides and apoproteins A and B.

RESULTS:

Triglycerides, apoprotein B and VLDL were significantly increased just before transplantation among patients who developed fatal pancreatitis compared to those patients with good graft function.

CONCLUSION:

Recipient hypertriglyceridemia promotes graft pancreatitis in previously injured pancreatic graft.

• Authors: T Grochowiecki, J Szmidt, Z Galazka, S Nazarewski, K Kuczynska, H Berent, M Durlik, T Jakimowicz, M Wojtaszek, Z Gaciong
• Journal: Transplantation proceedings (Transplant Proc) Vol. 35 Issue 6 Pg. 2339-40 (Sep 2003) ISSN: 0041-1345 [Print] United States
• PMID: 14529934 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Triglycerides

Topics

• Adult
• Biomarkers (blood)
• Female
• Humans
• Kidney Transplantation (physiology)
• Male
• Pancreas Transplantation (pathology)
• Pancreatitis (epidemiology, mortality)
• Postoperative Complications (epidemiology, mortality)
• Retrospective Studies
• Risk Factors
• Triglycerides (blood)