A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
Also Known As:
Breakpoint Cluster Region Protein; Proto-Oncogene Protein bcr; Proto-Oncogene Protein c-bcr; c-bcr Proto-Oncogene Proteins; Proto Oncogene Protein bcr; Proto Oncogene Protein c bcr; Proto Oncogene Proteins c bcr; Proto-Oncogene Proteins, bcr; Proto-Oncogene Proteins, c-bcr; bcr Proto Oncogene Proteins; c bcr Proteins; c bcr Proto Oncogene Proteins; c-bcr, Proto-Oncogene Protein; c-bcr, Proto-Oncogene Proteins; bcr Proto-Oncogene Proteins; c-bcr Proteins