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Gram-Positive Bacterial Infections

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Infections caused by bacteria that retain the crystal violet stain (positive) when treated by the gram-staining method.

Also Known As:

Infections, Gram-Positive Bacterial; Bacterial Infection, Gram-Positive; Bacterial Infections, Gram Positive; Gram Positive Bacterial Infections; Gram-Positive Bacterial Infection; Infection, Gram-Positive Bacterial; Infections, Gram Positive Bacterial; Bacterial Infections, Gram-Positive

Networked: 158 relevant articles (15 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Bacterial Infections and Mycoses
- Bacterial Infections: 10283
  - Gram-Positive Bacterial Infections: 158

Related Diseases

1.	Infection
2.	Endocarditis
3.	Pneumonia (Pneumonitis)
4.	Thrombocytopenia (Thrombopenia)
5.	Sepsis (Septicemia)

Experts

1.	Sobel, Jack D: 3 articles (07/2011 - 09/2004)
2.	Falagas, Matthew E: 3 articles (05/2009 - 01/2008)
3.	Timerman, Artur: 2 articles (06/2015 - 11/2013)
4.	Lyu, Syue-Yi: 2 articles (08/2014 - 04/2012)
5.	Liu, Yu-Chen: 2 articles (08/2014 - 04/2012)
6.	Li, Tsung-Lin: 2 articles (08/2014 - 04/2012)
7.	Wright, Gerard D: 2 articles (07/2012 - 04/2007)
8.	Cygler, Miroslaw: 2 articles (07/2012 - 04/2007)
9.	Sulea, Traian: 2 articles (07/2012 - 04/2007)
10.	Shi, Rong: 2 articles (07/2012 - 04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gram-Positive Bacterial Infections:

1.	linezolid (Zyvox)FDA Link 06/01/2003 - "Linezolid is a novel oxazolidinone antibiotic that is effective for the treatment of gram-positive bacterial infections. " 05/01/2011 - "Taking into account the potential bias in comparing heterogeneous clinical trials and reports, the available literature data suggest that linezolid is a safe and effective agent for the treatment of serious Gram-positive bacterial infections in neonates and children. " 05/01/2013 - "Conclusions : Linezolid is effective and safe for the elderly with gram-positive bacterial infections. " 03/01/2014 - "This study aimed to evaluate the efficacy and safety of linezolid in treating Gram-positive bacterial infection in the elderly from January 2010 to December 2012. " 01/01/2008 - "Linezolid versus glycopeptide or beta-lactam for treatment of Gram-positive bacterial infections: meta-analysis of randomised controlled trials."
2.	Vancomycin FDA LinkGeneric 02/01/2007 - "Vancomycin (VCN) is a glycopeptide antibiotic that is effective in the treatment of gram-positive bacterial infections, but mainly reserved for methicilin resistant Staphylococcus aureus. " 09/01/1990 - "All gram-positive bacterial infections failing first line therapy were cured after the addition of vancomycin. " 05/01/2015 - "Vancomycin, a glycopeptide antibiotic, has long been a drug of choice for life-threatening Gram-positive bacterial infections. " 07/01/2014 - "Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive bacterial infections. " 03/01/2014 - "Use of vancomycin has increased following the emergence of resistant Gram-positive bacterial infections. "
3.	TeicoplaninIBA 01/01/1988 - "Teicoplanin, a new antibiotic effective against gram-positive bacterial infections of the skin and soft tissues." 11/01/2008 - "Teicoplanin (teic) from Actinoplanes teichomyceticus is a glycopeptide antibiotic used to treat many gram-positive bacterial infections. " 08/01/2007 - "The authors assessed the relationship between total and free concentrations of teicoplanin in serum samples obtained from patients receiving teicoplanin therapy for Gram-positive bacterial infections. " 12/01/1990 - "Treatment of bone, joint, and vascular-access-associated gram-positive bacterial infections with teicoplanin." 05/01/1988 - "Teicoplanin--a new agent for gram-positive bacterial infections."
4.	beta-Lactamases (beta-Lactamase)IBA 03/01/1995 - "In the cases of infections with beta-lactamase producing strains, bacteriological efficacy rates were 80.0% in cases with Gram-positive bacterial infections, 75.0% in those with Gram-negative bacterial infections, and 100% in those with anaerobic bacterial infections. " 05/01/1990 - "The present study examined the efficacy of teicoplanin, a glycopeptide antibiotic active against gram-positive bacterial infections in various animal models, in the treatment of experimental endocarditis due to a beta-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin. "
5.	Gentamicins (Gentamicin)FDA LinkGeneric 05/01/1990 - "The present study examined the efficacy of teicoplanin, a glycopeptide antibiotic active against gram-positive bacterial infections in various animal models, in the treatment of experimental endocarditis due to a beta-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin. "
6.	Anti-Bacterial Agents (Antibiotics)IBA 04/01/2012 - "Glycopeptide antibiotics are clinically important medicines to treat serious Gram-positive bacterial infections. " 02/01/2012 - "New antibiotics are needed, and we have developed a promising drug candidate that may be applicable to treating MRSA, among other gram-positive bacterial infections. " 12/01/2011 - "With regard to antibiotics, several options are available for treating gram-positive bacterial infections. " 11/11/2008 - "Glycopeptide antibiotics have long served as drugs of last resort for the treatment of antibiotic-resistant gram-positive bacterial infections. " 05/01/2007 - "In patients who did not respond to prior antibiotic treatment for a Gram-positive bacterial infection (n=26), the mean duration of prior therapy with antibiotics was 6.0 d and the cost was $287. "
7.	ResistinIBA 11/21/2008 - "Our results suggest that resistin interferes with the efficacy of immune responses activated by Gram-positive bacterial infection in human DCs."
8.	ChitosanIBA 11/10/2015 - "The present work evaluated the feasibility of chitosan coated liposomes (c-Lips) for the intravenous delivery of vancomycin hydrochloride (VANH), a water-soluble antibiotic for the treatment of gram-positive bacterial infections like osteomyelitis, arthritis, endocarditis, pneumonia, etc. The objective of this research was to develop a suitable drug delivery system in vivo which could improve therapeutic efficacy and decrease side effects especially nephrotoxicity. "
9.	Liposomes (Liposome)IBA 11/10/2015 - "The present work evaluated the feasibility of chitosan coated liposomes (c-Lips) for the intravenous delivery of vancomycin hydrochloride (VANH), a water-soluble antibiotic for the treatment of gram-positive bacterial infections like osteomyelitis, arthritis, endocarditis, pneumonia, etc. The objective of this research was to develop a suitable drug delivery system in vivo which could improve therapeutic efficacy and decrease side effects especially nephrotoxicity. "
10.	Erythromycin (Erycette)FDA LinkGeneric 04/01/1985 - "Erythromycin, first introduced for clinical use 30 years ago, was found to be effective for the treatment of gram-positive bacterial infections. "

Therapies and Procedures

1.	Injections 11/10/2015 - "These results revealed that injectable c-VANH-Lips may serve as a promising carrier for VANH to increase therapeutic efficacy on gram-positive bacterial infections and reduce nephrotoxicity, which provides significantly clinical value for long-term use of VANH. " 02/01/2005 - "Theravance is developing telavancin, an injectable peptidoglycan inhibitor antibiotic for potential use in the treatment of Gram-positive bacterial infection. "
2.	Debridement 03/01/2007 - "Maggot debridement therapy (MDT) has been proven to be very effective in the treatment of gram-positive bacterial infections. "
3.	Transplants (Transplant) 02/01/1990 - "A canine model was developed to study the differential response of a gram-negative and a gram-positive bacterial infection on autogenous and prosthetic grafts. "
4.	Catheters 01/01/2014 - "This was in contrast to gram positive bacterial infections, which decreased over time despite having shown the highest possibility of death earlier in catheter days. " 12/01/2007 - "Continuous infusion might be an attractive option to treat tunnel Gram-positive bacterial infections when catheter removal might not be feasible or advisable." 10/01/2006 - "Since over 80% of BSI were considered catheter-related, the higher incidence of gram-positive bacterial infections was likely due to the presence of indwelling central venous catheters. " 12/01/2007 - "We treated 13 episodes of tunnel Gram-positive bacterial infection occurring in pediatric patients with cancer or serious blood disorders with 24-hr intra-catheter antibiotic continuous infusion. " 09/01/2011 - "Chronic hepatitis C [relative risk (RR) = 3.37, 95% confidence interval (CI) = 1.24-9.13, P = 0.02], initial septic shock (RR = 15.13, 95% CI = 2.84-80.54, P = 0.001), and central venous catheter-related bacteremia (RR = 7.22, 95% CI = 2.54-20.51, P < 0.001) were significantly associated with 90-day all-cause mortality after gram-positive bacterial infections. "
5.	Liver Transplantation 07/01/2012 - "Analysis of Gram-positive bacterial infection in patients following liver transplantation." 07/01/2012 - "aureus and Enterococcus were the main pathogens causing infection following liver transplantation in patients with drug-resistant Gram-positive bacterial infection. " 07/01/2012 - "The purpose of this research was to investigate the molecular epidemiology and the influence of multidrug-resistant Gram-positive infection in patients, following liver transplantation, to provide reference for clinical treatment and prevention of Gram-positive bacterial infection. " 09/01/2011 - "Toll-like receptor 2 polymorphism and Gram-positive bacterial infections after liver transplantation." 07/01/2012 - "Reasonable use of antibiotics, decreasing intra-operative blood input, and preventing post-operative renal failure may reduce Gram-positive bacterial infections and the appearance of drug-resistant strains following liver transplantation."