Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification.

Abstract

Glycopeptide antibiotics are clinically important medicines to treat serious Gram-positive bacterial infections. The emergence of glycopeptide resistance among pathogens has motivated considerable interest in expanding structural diversity of glycopeptide to counteract resistance. The complex structure of glycopeptide poses substantial barriers to conventional chemical methods for structural modifications. By contrast, biochemical approaches have attracted great attention because ample biosynthetic information and sophisticated toolboxes have been made available to change reaction specificity through protein engineering, domain swapping, pathway engineering, addition of substrate analogs, and mutagenesis.

• Authors: Tsung-Lin Li, Yu-Chen Liu, Syue-Yi Lyu
• Journal: Current opinion in chemical biology (Curr Opin Chem Biol) Vol. 16 Issue 1-2 Pg. 170-8 (Apr 2012) ISSN: 1879-0402 [Electronic] England
• PMID: 22336892 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Glycopeptides

Topics

• Anti-Bacterial Agents (chemistry, metabolism)
• Biocatalysis
• Glycopeptides (chemistry, metabolism)
• Oxidation-Reduction