Abstract | BACKGROUND AND OBJECTIVES: METHODS: From July 2017 to July 2019, clinical and sociodemographic data were collected for all hospitalized patients switched to dalbavancin for the treatment of Gram-positive infections. LOS and treatment-related costs were assessed and compared to a hypothetical scenario where the initial standard antimicrobial therapy would have been administered in hospital for the same duration as dalbavancin. RESULTS: A total of 50 patients were enrolled. The observed infections were: acute bacterial skin and skin structure infections (ABSSSIs, 12 patients), complicated ABSSSIs (eight patients), osteoarticular infections (18 patients), vascular graft or cardiovascular implantable electronic devices (CIED) infections (12 patients). After a median of 14 [interquartile range (IQR) 7-28] days, the in-hospital antimicrobial therapy was switched to dalbavancin 1500 mg. When appropriate, considering the site and the clinical course of the infection, 1500 mg doses were repeated every 14 days until recovery. Overall, 49/50 (98%) patients reported clinical success at the end of therapy. No relapses were observed in 37 patients for whom a median follow-up of 150 (IQR 30-180) days was available. By switching to dalbavancin, a median of €8,259 (IQR 5644-17,270) and 14 hospital days (IQR 22-47) per patient were saved. CONCLUSIONS: In this experience, the use of dalbavancin contributed to shorten LOS and treatment-related costs, especially in difficult Gram-positive infections requiring prolonged therapy.
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Authors | Mariacristina Poliseno, Davide Fiore Bavaro, Gaetano Brindicci, Giovanni Luzzi, Domenico Maria Carretta, Antonio Spinarelli, Raffaella Messina, Maria Paola Miolla, Teresa Immacolata Achille, Maria Rosaria Dibartolomeo, Maria Dell'Aera, Annalisa Saracino, Gioacchino Angarano, Stefano Favale, Carlo D'Agostino, Biagio Moretti, Francesco Signorelli, Camilla Taglietti, Sergio Carbonara |
Journal | Clinical drug investigation
(Clin Drug Investig)
Vol. 41
Issue 5
Pg. 437-448
(May 2021)
ISSN: 1179-1918 [Electronic] New Zealand |
PMID | 33884583
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Teicoplanin
- dalbavancin
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Topics |
- Aged
- Anti-Bacterial Agents
(administration & dosage)
- Cohort Studies
- Female
- Gram-Positive Bacterial Infections
(drug therapy, microbiology)
- Health Care Costs
- Hospitals
- Humans
- Length of Stay
- Male
- Middle Aged
- Retrospective Studies
- Teicoplanin
(administration & dosage, analogs & derivatives)
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