Wallerian Degeneration

Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
Also Known As:
Degeneration, Wallerian
Networked: 548 relevant articles (14 outcomes, 57 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hyperalgesia
2. Muscular Atrophy (Muscle Atrophy)
3. Demyelinating Diseases (Demyelinating Disease)
4. Nerve Degeneration
5. Neuralgia (Stump Neuralgia)


1. Coleman, Michael P: 12 articles (04/2015 - 02/2002)
2. Gillingwater, Thomas H: 8 articles (04/2012 - 09/2003)
3. Ribchester, Richard R: 8 articles (06/2011 - 09/2003)
4. Myers, Robert R: 7 articles (12/2011 - 03/2002)
5. Jung, Junyang: 6 articles (04/2014 - 12/2009)
6. Wishart, Thomas M: 6 articles (04/2012 - 02/2006)
7. Stoll, Guido: 6 articles (03/2008 - 01/2002)
8. Brück, W: 6 articles (10/2001 - 08/2000)
9. Sasaki, Yo: 5 articles (04/2015 - 08/2004)
10. Milbrandt, Jeffrey: 5 articles (04/2015 - 08/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wallerian Degeneration:
1. Messenger RNA (mRNA)IBA
2. Sodium Channels (Sodium Channel)IBA
3. Proteasome Endopeptidase Complex (Proteasome)IBA
4. Substance PIBA
5. Calcitonin Gene-Related PeptideIBA
6. Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
7. Nerve Growth Factors (Neurotrophins)IBA
04/01/2011 - "In the 6th week, all the morphometric results of the group 4 were statistically better compared with groups 2 and 3. There was a statistically significant improvement in the sciatic functional index for group 4 compared with groups 2 and 3. Mononuclear cells stimulated nerve regeneration, most probably by speeding up the Wallerian degeneration process as well as stimulating the synthesis of neurotrophic factors."
10/01/2009 - "Thus, the sensory neurons could be preprimed in the regenerative milieu of Wallerian degeneration and neuroinflammation, which might alter the expression of neurotrophic factors and their receptors, facilitating sprouting/regeneration of ascending sensory neurons."
10/01/2001 - "The basis by which uninjured nerves could be affected is a reduced supply of neurotrophic factors, an abnormal interaction in the Remak bundles of partially denervated Schwann cells and unmyelinated axons, or the byproducts of Wallerian degeneration."
03/01/1996 - "The cellular responses that take place during Wallerian degeneration, including the elaboration of neurotrophins, are increasingly recognized to set the stage for the success or failure of subsequent regeneration, and manipulations of Wallerian degeneration are being investigated as a potential means of altering the outcome of nerve regeneration."
09/01/2015 - "The aim of this review is to summarize contemporary evidence regarding: (1) the origin and development of SCs in the peripheral and penile nerve system; (2) Wallerian degeneration and SC plastic change following peripheral and penile nerve injury; (3) how SCs promote peripheral and penile nerve regeneration by secreting neurotrophic factors; (4) and strategies targeting SCs to accelerate peripheral nerve regeneration. "
8. Vincristine (Oncovin)FDA LinkGeneric
9. RNA (Ribonucleic Acid)IBA
10. Caspase 3 (Caspase-3)IBA

Therapies and Procedures

1. Axotomy
2. Nerve Crush
3. Transplants (Transplant)
4. Intraperitoneal Injections
5. Ganglionectomy