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Wallerian Degeneration

Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
Also Known As:
Degeneration, Wallerian
Networked: 760 relevant articles (18 outcomes, 70 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Peripheral Nerve Injuries
2. Hyperalgesia
3. Muscular Atrophy (Muscle Atrophy)
4. Brain Concussion (Cerebral Concussion)
5. Ataxia (Dyssynergia)

Experts

1. Coleman, Michael P: 24 articles (02/2022 - 02/2002)
2. Ribchester, Richard R: 13 articles (11/2014 - 09/2003)
3. Gilley, Jonathan: 10 articles (02/2022 - 02/2009)
4. Adalbert, Robert: 10 articles (01/2021 - 03/2004)
5. Conforti, Laura: 10 articles (01/2020 - 02/2002)
6. Gillingwater, Thomas H: 10 articles (04/2012 - 09/2003)
7. Wishart, Thomas M: 8 articles (04/2012 - 02/2006)
8. Myers, Robert R: 8 articles (12/2011 - 03/2002)
9. Beirowski, Bogdan: 8 articles (10/2010 - 03/2004)
10. Bittner, George D: 7 articles (12/2020 - 09/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wallerian Degeneration:
1. Proteins (Proteins, Gene)FDA Link
2. Messenger RNA (mRNA)IBA
3. Sodium Channels (Sodium Channel)IBA
4. Proteasome Endopeptidase Complex (Proteasome)IBA
5. Substance PIBA
6. Interleukin-4 (Interleukin 4)IBA
7. Calcitonin Gene-Related PeptideIBA
8. Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
9. Nerve Growth Factors (Neurotrophins)IBA
04/01/2011 - "In the 6th week, all the morphometric results of the group 4 were statistically better compared with groups 2 and 3. There was a statistically significant improvement in the sciatic functional index for group 4 compared with groups 2 and 3. Mononuclear cells stimulated nerve regeneration, most probably by speeding up the Wallerian degeneration process as well as stimulating the synthesis of neurotrophic factors."
10/01/2001 - "The basis by which uninjured nerves could be affected is a reduced supply of neurotrophic factors, an abnormal interaction in the Remak bundles of partially denervated Schwann cells and unmyelinated axons, or the byproducts of Wallerian degeneration."
02/15/2000 - "We focus on two models of selective axon degeneration: Wallerian degeneration of transected axons and localized axon degeneration induced by local deprivation of neurotrophin. "
03/01/1996 - "The cellular responses that take place during Wallerian degeneration, including the elaboration of neurotrophins, are increasingly recognized to set the stage for the success or failure of subsequent regeneration, and manipulations of Wallerian degeneration are being investigated as a potential means of altering the outcome of nerve regeneration."
10/01/2009 - "Thus, the sensory neurons could be preprimed in the regenerative milieu of Wallerian degeneration and neuroinflammation, which might alter the expression of neurotrophic factors and their receptors, facilitating sprouting/regeneration of ascending sensory neurons."
10. Interleukin Receptors (Interleukin Receptor)IBA

Therapies and Procedures

1. Axotomy
2. Nerve Crush
3. Intraperitoneal Injections
4. Physical Therapy Modalities (Physical Therapy Technique)
5. Denervation