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Fenfluramine

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A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.

Also Known As:

Fenfluramine Hydrochloride; Fenfluramine Hydrochloride, (+-)-Isomer; Fenfluramine Hydrochloride, R-Isomer; Fenfluramine, (+-)-Isomer; Fenfluramine, R-Isomer; Isomeride; Pondimin; Robins Brand of Fenfluramine Hydrochloride; Fenfluramine Hydrochloride, R Isomer; Fenfluramine, R Isomer; Hydrochloride, Fenfluramine; Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-

Networked: 742 relevant articles (39 outcomes, 83 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rothman, Richard B: 7 articles (11/2010 - 04/2002)
2.	Baumann, Michael H: 5 articles (07/2009 - 04/2002)
3.	Mann, J John: 4 articles (03/2014 - 05/2003)
4.	Rubin, Lewis J: 4 articles (01/2009 - 08/2005)
5.	Rothman, R B: 4 articles (04/2006 - 04/2000)
6.	Davis, K D: 4 articles (10/2001 - 04/2000)
7.	Lagae, Lieven: 3 articles (11/2015 - 07/2012)
8.	Ceulemans, Berten: 3 articles (11/2015 - 07/2012)
9.	Malone, Kevin M: 3 articles (03/2014 - 05/2003)
10.	Oquendo, Maria A: 3 articles (03/2014 - 05/2003)

Related Diseases

1.	Weight Loss (Weight Reduction) 08/01/1988 - "Rate of weight loss was significantly greater in those taking D-fenfluramine. " 11/01/1981 - "Fenfluramine produced significantly greater weight losses than no medication, but patients in the medication group regained weight much more rapidly during a 12-month maintenance period. " 01/01/1989 - "Three month studies of Isomeride plus diet versus placebo plus diet have shown an average weight loss of 3 kilograms in the first month and 7 kilograms after 3 months treatment in the Isomeride group. " 01/01/1988 - "The rate of weight loss was linear up to the end of the trial in d-fenfluramine patients. " 01/01/1988 - "However, in long term clinical studies, drug levels were only weakly related to weight loss and other undefined factors seem to determine which patients responded better to fenfluramine treatment."
2.	Obesity 02/19/1983 - "Long-term efficacy of fenfluramine in treatment of obesity." 11/01/1995 - "d Fenfluramine (dF) (15 mg twice daily) has been studied in controlled trials in human obesity. " 05/01/1992 - "A prospective, randomised case-control trial of an anorectic drug, fenfluramine was conducted on 30 patients of simple obesity. " 01/01/1992 - "d-Fenfluramine (dF) (15 mg twice daily) has been studied in controlled trials in human obesity and has been shown to increase adherence to diet, to enhance its efficacy, and most importantly, to prevent weight regain when continued over 1 y. " 02/05/1972 - "A trial of fenfluramine in children with obesity associated with reduced muscle activity."
3.	Body Weight (Weight, Body) 04/01/1988 - "Body weight loss following acute treatment with fenfluramine was significantly greater at three and twenty-four hours than in the vehicle-treated controls. " 10/01/2007 - "In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time." 01/01/1988 - "Three studies have been undertaken to investigate why there are individual differences in the response to d-fenfluramine with respect to food intake and hunger in the short term and on body weight loss in the long term. " 10/01/1985 - "In a dose-response study there was no significant increase with doses of 2 or 6 mg/kg but there was a significant increase at 20 mg/kg. During eleven days of treatment, food intake was initially depressed by fenfluramine (20 mg/kg) and body weight was significantly reduced. " 01/01/1985 - "In conclusion, in long-term treatment with fenfluramine, in contrast with short-term studies, no direct effect of this drug on body-weight and adipose mass decrease was demonstrated."
4.	Panic Disorder (Panic Attack) 06/01/1989 - "Panic disorder patients revealed significantly greater anxiogenic responses to fenfluramine administration at all 5 hourly measurement points than either depressed patients or control subjects. " 05/15/2000 - "Increased left posterior parietal-temporal cortex activation after D-fenfluramine in women with panic disorder." 07/01/1997 - "Hormonal response during a fenfluramine-associated panic attack." 04/01/1994 - "Controlling panic attacks with fenfluramine." 03/01/1994 - "Serotonergic function in panic disorder: endocrine responses to D-fenfluramine."
5.	Hyperphagia 12/01/1988 - "The drug d-fenfluramine was administered chronically to rats whose weight had been increased by exposure to either a fat or CHO-supplemented hyperphagia-inducing diet. " 01/01/1988 - "Were it not for this high rate of defaulting, there might be clearer support for the efficacy of d-fenfluramine in reducing the frequency of overeating and self-induced vomiting in these bulimic patients. " 12/01/1988 - "d-Fenfluramine was equally effective against the hyperphagia and weight gain induced by either fat or CHO supplements." 01/01/1988 - "This rat model successfully predicted feeding patterns under a variety of normal and abnormal conditions, including the day-night meal rhythm, the overeating and obesity following ventromedial hypothalamic lesions, and the suppression of appetite by fenfluramine via slowed gastric emptying. " 02/14/1995 - "The results suggest that d-fenfluramine reduces neuropeptide Y's hyperphagia by indirectly stimulating 5-HT1B receptors outside the paraventricular nucleus of the hypothalamus."

Related Drugs and Biologics

1.	Phentermine (Adipex-P)
2.	Serotonin (5 Hydroxytryptamine)
3.	Prolactin
4.	Dexfenfluramine (Redux)
5.	Hydrocortisone (Cortisol)
6.	Insulin (Novolin)
7.	Mazindol (Mazanor)
8.	sibutramine (Meridia)
9.	Diethylpropion (Amfepramone)
10.	Blood Glucose (Blood Sugar)

Related Therapies and Procedures

1.	Caloric Restriction
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Subcutaneous Infusions
5.	Induced Hyperthermia (Thermotherapy)