Duane Retraction Syndrome (Duane Syndrome)

A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE.
Also Known As:
Duane Syndrome; Syndrome, Duane; Duanes Syndrome; Syndrome, Duane's; Duane Retraction Syndrome 1; Duane Retraction Syndrome 2; Duane Retraction Syndrome, Type 1; Duane Retraction Syndrome, Type 2; Duane Retraction Syndrome, Type 3; Duane's Syndrome; Okihiro Syndrome; Type 1 Duane Retraction Syndrome; Type 2 Duane Retraction Syndrome; Type 3 Duane Retraction Syndrome; Ocular Retraction Syndromes; Retraction Syndrome, Duane; Retraction Syndrome, Ocular; Retraction Syndromes, Ocular; Syndrome, Duane Retraction; Syndrome, Ocular Retraction; Syndrome, Okihiro; Syndromes, Ocular Retraction; Ocular Retraction Syndrome
Networked: 93 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Esotropia (Esophoria)
2. Paralysis (Palsy)
3. Torticollis (Wryneck)
4. Deafness (Deaf Mutism)
5. Hearing Loss (Hearing Impairment)


1. Engle, Elizabeth C: 5 articles (04/2012 - 11/2002)
2. Kohlhase, Jürgen: 5 articles (05/2007 - 11/2002)
3. Khan, Arif O: 3 articles (06/2015 - 06/2006)
4. Chan, Wai-Man: 3 articles (04/2012 - 11/2002)
5. Demer, Joseph L: 3 articles (08/2011 - 11/2006)
6. Demircan, A: 2 articles (06/2015 - 10/2013)
7. Gokyigit, B: 2 articles (06/2015 - 10/2013)
8. Oystreck, Darren T: 2 articles (06/2015 - 03/2014)
9. Pekel, G: 2 articles (06/2015 - 10/2013)
10. Abu-Amero, Khaled K: 2 articles (06/2015 - 03/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Duane Retraction Syndrome:
1. Carbon MonoxideIBA
2. oxaceprol (AHP)IBA
10/01/2013 - "In Duane syndrome patients, the deviation was reduced by a mean of 95%, the AHP was eliminated in 86% of patients, the abduction was improved by 42%, and a useful BSVF of ≈ 67% of normal was achieved at 1 year post operation. "
01/01/2004 - "Unilateral or bilateral horizontal rectus muscle recession offers a simple and effective surgical option for eliminating AHP and is our treatment of choice in patients with Duane's syndrome."
10/01/2013 - "VRT surgery with posterior fixation is an effective treatment method for complete sixth nerve palsy and Duane syndrome with esotropia, AHP, and abduction deficiency. "
01/01/2004 - "Patients with Duane's syndrome undergoing strabismus surgery of a horizontal muscle recession procedure, medial rectus recession for an esodeviation or lateral rectus recession for an exodeviation, in order to correct an abnormal head position (AHP) and a significant tropia in primary position were identified. "
01/01/2011 - "There are ocular diseases which diagnosis is straightforward for general practitioner, pediatricians or pediatric surgeons (horizontal nystagmus, lateral rectus paralysis, ptosis, esotropia), but others less obvious (superior oblique paralysis, Duane syndrome, A and V-pattern strabismus, torsional nystagmus) because of the compensatory head posture, and these last disorders are predisposed to confusion with congenital AHP Interdisciplinary collaboration between ophthalmologist, pediatrician, pediatric surgeon, ENT specialist and neurologist is mandatory in establishing the etiology of AHP Every child with AHP must be examined by an ophthalmologist."
3. Botulinum Toxins (Botulinum Toxin)IBA
4. Transcription Factors (Transcription Factor)IBA
5. Wildervanck syndromeIBA
6. Duane anomalyIBA
7. Marcus Gunn phenomenonIBA
8. Thalidomide (Thalomid)FDA Link
9. Retinaldehyde (Retinal)IBA
10. Schmid-Fraccaro syndromeIBA

Therapies and Procedures

1. Sutures (Suture)
2. Denervation
3. Tenotomy
4. Injections
5. Eyeglasses (Spectacles)