Thalidomide (Thalomid)

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

Also Known As:

Networked: 3480 relevant articles (542 outcomes, 683 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Palumbo, Antonio: 59 articles (08/2015 - 01/2004)
2.	Anderson, Kenneth C: 38 articles (07/2013 - 04/2002)
3.	Boccadoro, Mario: 33 articles (10/2014 - 01/2004)
4.	Figg, William D: 29 articles (04/2010 - 02/2002)
5.	Cavo, Michele: 28 articles (12/2014 - 03/2002)
6.	Rajkumar, S Vincent: 27 articles (09/2015 - 11/2002)
7.	Barlogie, Bart: 25 articles (06/2013 - 04/2002)
8.	Musto, Pellegrino: 24 articles (10/2014 - 04/2002)
9.	Bringhen, Sara: 24 articles (10/2014 - 01/2004)
10.	Richardson, Paul G: 24 articles (08/2014 - 06/2002)

Related Diseases

1.	Multiple Myeloma 01/01/2015 - "Thalidomide is highly effective against multiple myeloma, but some patients must discontinue this medication due to adverse effects. " 06/01/2004 - "Thalidomide has demonstrated a remarkable efficacy in the treatment of multiple myeloma but its use may cause several toxicities. " 01/01/2004 - "s-Thalidomide has proven efficacy in multiple myeloma. " 01/01/2003 - "Thalidomide is presently used in therapy of patients with resistant and relapsed multiple myeloma with very promising results." 01/01/2002 - "Thalidomide has recently proven to be a useful drug for treatment of refractory and relapsed multiple myeloma patients, up to 35% of whom achieve remission. "
2.	Neoplasms (Cancer) 11/01/2009 - "Thalidomide alone delayed tumor growth, but the combination of thalidomide with OncdSyn appeared to produce the best results." 02/01/2008 - "Thalidomide administered orally in combination with SBE7betaCD, led to a significant delay in tumor formation as a result of improved cellular drug absorption, distribution through solubilization in experimental animals. " 11/21/2006 - "Thalidomide was significantly more likely to be effective in tumors smaller than 5 cm (PR + SD: 63.6% vs PD: 25.8%, P = 0.034 < 0.05). " 10/01/2001 - "The administration of thalidomide, which was suggested to be beneficial in the treatment of human cancers, had no substantial clinical effect on our patient. " 07/01/2003 - "However, thalidomide has been established to be useful in the treatment of various diseases including cancer. "
3.	Crohn Disease (Crohn's Disease) 05/01/2001 - "In open-label trials, thalidomide has demonstrated efficacy in patients with refractory Crohn's disease; however, the therapeutic potential of thalidomide may be severely limited by the high incidence of drug-induced side effects. " 03/01/2015 - "Several open-label and retrospective studies have indicated that thalidomide may be beneficial in patients with refractory Crohn's disease (CD). " 01/01/2005 - "The results show that both APA and AC capsules allow for successful delivery of thalidomide in the gut and could prove beneficial in the treatment of Crohn's disease. " 08/01/2015 - "In a randomized controlled trial, thalidomide has shown to be effective in refractory Crohn's disease in children. " 11/27/2013 - "To determine whether thalidomide is effective in inducing remission in refractory pediatric Crohn disease. "
4.	Erythema Nodosum 08/01/1976 - "Reactive episodes continue to be a serious complication, but the availability of thalidomide to control erythema nodosum leprosum has markedly improved the prognosis. " 04/01/2010 - "Thalidomide (Thal) provides effective treatment for erythema nodosum leprosum (ENL). " 12/15/2005 - "Effective treatment of erythema nodosum leprosum with thalidomide is associated with immune stimulation." 10/20/2001 - "In 1964 it was discovered that thalidomide was effective against erythema nodosum leprosum. " 03/01/1998 - "The efficacy of thalidomide in the treatment of erythema nodosum leprosum is a well established fact; there is also accumulating evidence of its therapeutic value in a number of other inflammatory and immune-mediated conditions. "
5.	Leprosy (Hansen's Disease) 02/01/2007 - "As expected, overall, thalidomide proved to be more effective in the treatment of type II leprosy reaction. " 10/01/2009 - "In this study, comparisons were made regarding the plasma concentrations of thalidomide in patients with ENL on the course or after leprosy therapy in a prospective clinical trial. " 10/01/1986 - "Thalidomide in leprosy--study of 94 cases." 10/01/1969 - "Motor conduction velocity studies in patients with leprosy reaction treated with thalidomide and other drugs." 10/01/1968 - "Trials with thalidomide derivatives in leprosy reactions."

Related Drugs and Biologics

1.	bortezomib (Velcade)
2.	lenalidomide (CC 5013)
3.	Dexamethasone (Maxidex)
4.	Cyclophosphamide (Cytoxan)
5.	Melphalan (Alkeran)
6.	Prednisone (Sone)
7.	Proteasome Endopeptidase Complex (Proteasome)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Adrenal Cortex Hormones (Corticosteroids)
10.	Prednisolone (Predate)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Stem Cell Transplantation
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Radiotherapy
5.	Aftercare (After-Treatment)