Salvage Therapy

A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

Also Known As:

Networked: 1806 relevant articles (196 outcomes, 211 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Kantarjian, Hagop: 14 articles (09/2015 - 04/2003)
2.	Faderl, Stefan: 13 articles (10/2013 - 04/2003)
3.	Cortes, Jorge: 11 articles (09/2015 - 04/2003)
4.	O'Brien, Susan: 10 articles (01/2015 - 08/2005)
5.	Chamberlain, Marc C: 9 articles (04/2015 - 09/2007)
6.	Reni, Michele: 8 articles (11/2013 - 09/2003)
7.	Garcia-Manero, Guillermo: 8 articles (06/2013 - 04/2003)
8.	Ravandi, Farhad: 8 articles (06/2013 - 07/2007)
9.	Yen, Tzu-Chen: 8 articles (01/2013 - 02/2004)
10.	Walsh, Thomas J: 8 articles (06/2009 - 01/2004)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2005 - "In fact, patients who had no or only one risk factor and patients who had tumors with a nonalveolar histology benefited more from salvage therapy if they had not received radiotherapy for their initial treatment. " 05/01/1993 - "The analysis included stage and distribution of disease, tumor-cell phenotype, response to initial and salvage therapy, and disease-free and overall survival. " 12/01/2006 - "However, when developing surveillance strategies for large groups of patients, knowledge of the risks (tumor biology, natural history of the disease), the benefits (potential efficacy of salvage therapy) and diagnosis test performances is necessary to formulate a rationale and resource effective follow-up algorithm. " 02/01/2006 - "However, when developing surveillance strategies for large groups of patients, knowledge of the risks (tumor biology, natural history of the disease), the benefits (potential efficacy of salvage therapy) and diagnosis test performances is necessary to formulate a rationale and resource effective follow-up algorithm." 10/01/1991 - "The variables identified need to be incorporated into future trials testing the efficacy of salvage therapy for patients with nonseminomatous tumors of the testis."
2.	Lymphoma (Lymphomas) 07/01/1997 - "These results demonstrate that IVE is a highly effective mobilization regimen which is superior to cyclophophamide and has the benefit of being effective salvage therapy for lymphoma patients." 11/01/2013 - "Whole-brain radiotherapy (WBRT) plays an important role in the management of primary CNS lymphoma and is indicated in patients with contraindication to chemotherapy, in patients with unusual histologic subtypes as curative treatment, as complementary therapy for patients failing to achieve complete remission after systemic chemotherapy and as salvage therapy for refractory or relapsing patients when systemic chemotherapy is no longer advisable. " 10/18/2009 - "Complete remission has been achieved in 9 patients with cerebral and in 4 patients with spinal cord lymphoma (13/22; 59.0%), however, one relapsed patient became resistant and later expired, despite salvage therapy. " 08/01/1994 - "Although the majority of patients with lymphoma achieve a complete remission with primary therapy, two thirds or more will fail to achieve an initial remission or will eventually relapse from complete remission and require salvage therapy. " 09/01/2013 - "Despite a high proportion of patients with primary CNS lymphoma (PCNSL) experiences failure after/during first-line treatment, a few studies focused on salvage therapy are available, often with disappointing results. "
3.	Hodgkin Disease (Hodgkin's Disease) 01/01/2014 - "Hodgkin's disease is highly curable by radiotherapy and/or chemotherapy, but refractory disease or early relapses are rarely cured by conventional salvage therapy. " 01/01/1993 - "Conventional salvage therapy in Hodgkin's disease is appropriate in patients who relapse after a first complete remission of greater than one year many of whom who will have good long term survival with no further therapy. " 08/01/1991 - "Two factors were responsible for the low death rate due to Hodgkin's disease: 1) 176 patients (74%) went into complete remission following initial therapy and did not experience a relapse; and 2) 63 patients relapsed following initial therapy; however, subsequent salvage therapy was successful in 44 (70%) of these 63 patients. " 01/01/1990 - "Forty-nine patients with Hodgkin's disease who relapsed after a first complete remission of more than 12 months following primary chemotherapy were treated with salvage therapy regimens. " 03/01/1990 - "Patients with Hodgkin's disease who have failed two or more chemotherapy regimens or who have relapsed after an initial chemotherapy-induced remission of less than 12 months are seldom cured with conventional salvage therapies. "
4.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 10/01/1996 - "The entry criteria included relapsed gonadal and extragonadal germ cell cancer unlikely to be cured by standard salvage therapy but without proven refractoriness to chemotherapy. " 11/01/2008 - "Establishment of gold-standard chemotherapy and the subsequent development of salvage therapy have much improved the prognosis of patients with testicular germ cell cancer. " 04/01/2003 - "The aim of this study was to identify treatment strategies and therapeutic or clinical factors that predict for response to salvage therapy and survival in patients with metastatic 'Indiana advanced' or International Germ-Cell Cancer Collaborative Group (IGCCCG) poor prognosis' germ cell cancer (GCT) failing first-line sequential high-dose chemotherapy plus autologous stem cell support (HD-CT). " 01/01/2015 - "Salvage therapy in patients with germ cell tumors." 02/01/2014 - "Salvage therapy for refractory or recurrent pediatric germ cell tumors: the French SFCE experience."
5.	Breast Neoplasms (Breast Cancer) 01/01/1986 - "We conclude that initial improvement in relapse-free survival may not predict long term survival in adjuvant breast cancer trials since both the specific adjuvant therapy given pre-relapse as well as the type of salvage therapy given post-relapse may influence ultimate patient outcome." 01/01/2002 - "The purpose of this article was to review the patterns and morbidity of regional recurrence (RR) in patients with early breast cancer, efficacy of salvage therapy for RR, and complications of regional nodal treatment. " 06/01/2008 - "Phase II trial of metronomic chemotherapy as salvage therapy for patients with metastatic breast cancer." 11/01/2011 - "In heavily pretreated metastatic breast cancer, significant improvements in progression-free survival may indicate a clinically meaningful benefit for patients with otherwise limited salvage therapy options available. " 01/01/2010 - "Consequently, also for the next years a MMC-containing chemotherapy continues to be a relevant part of an individualized therapy despite numerous innovative new drugs, especially for the salvage therapy of metastatic breast cancer and the simultaneous radiochemotherapy of other gynecological malignancies."

Related Drugs and Biologics

1.	Etoposide (VP 16)
2.	Cisplatin (Platino)
3.	Cytarabine (Cytosar-U)
4.	Ifosfamide
5.	Paclitaxel (Taxol)
6.	caspofungin (Cancidas)
7.	rituximab (Mabthera)
8.	posaconazole
9.	Cyclophosphamide (Cytoxan)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Stem Cell Transplantation
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Prostatectomy (Retropubic Prostatectomy)