Platinum

Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".

Also Known As:

Networked: 8390 relevant articles (876 outcomes, 1751 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Markman, Maurie: 52 articles (03/2014 - 02/2002)
2.	Sehouli, Jalid: 44 articles (05/2015 - 06/2003)
3.	Vergote, Ignace: 41 articles (12/2015 - 01/2003)
4.	Scambia, Giovanni: 32 articles (07/2015 - 01/2003)
5.	Vergote, I: 26 articles (01/2014 - 01/2000)
6.	Coleman, Robert L: 25 articles (04/2015 - 01/2002)
7.	Sood, Anil K: 24 articles (10/2015 - 08/2003)
8.	Gershenson, David M: 23 articles (08/2015 - 05/2002)
9.	Lippard, Stephen J: 23 articles (03/2015 - 12/2002)
10.	Zhang, Wei: 22 articles (09/2015 - 08/2004)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1998 - "These tumors are highly responsive to therapy with platinum-containing regimens, and 80% of cases so treated can be considered cured. " 09/01/2011 - "Cis-platin and other platinum complexes are important chemotherapeutic agents useful in the treatment of several cancers. " 05/01/2008 - "However, after 2 to 3 months of complete remission following platinum treatment, tumors relapse and become refractory to successive rounds of treatment. " 01/01/2014 - "Although this regimen is initially effective in a high percentage of cases, unfortunately within few months of initial treatment, tumor relapse occurs because of platinum-resistance. " 01/01/2014 - "Platinum-based chemotherapeutics are the mainstay of treatment of a range of tumors achieving high response rates but limited in the course of disease by appearance of drug resistance. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2006 - "By contrast, most studies indicate that women developing a BRCA1/2-related ovarian cancer have an improved survival compared with non-carriers, particularly if they receive platinum-based therapy. " 01/01/2014 - "Following elderly ovarian cancer patients over a lifetime using real-world longitudinal data and adjusting for quality of life, we found that treatment with platinum-based regimen was the most cost-effective treatment alternative." 01/01/2013 - "In women with platinum-sensitive recurrent ovarian cancer, ability to achieve surgery with complete cytoreduction (no visible residual disease) is associated with significant improvement in overall survival. " 01/01/1993 - "Platinum-containing regimens are very effective in the primary treatment of ovarian cancer. " 05/01/2014 - "The standard platinum-based treatment of previously untreated advanced ovarian cancer continues to evolve because despite high response rates to such first-line treatment, a majority of patients will experience relapse. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/01/2010 - "Standard first-line therapy for non-small-cell lung cancer (NSCLC) with platinum-based agents, given in combination with cytotoxic compounds, has reached a relative plateau in its therapeutic efficacy. " 08/01/2007 - "Third-generation platinum-based combinations are established as first-line treatment for advanced non-small cell lung cancer (NSCLC). " 10/01/2007 - "The aim of this study was to determine the impact of patient selection based on age, comorbidity and performance status on the efficacy of platinum-free combination therapy on non-small-cell lung cancer after 65 years of age. " 11/01/2013 - "Platinum doublets as first-line treatment for elderly patients with advanced non-small cell lung cancer." 02/01/2012 - "Platinum-based regimens represent the standard first-line treatment for non-small-cell lung cancer (nsclc). "
4.	Carcinoma (Carcinomatosis) 08/01/2011 - "Intratumoral lymphocyte density in serous ovarian carcinoma is superior to ERCC1 expression for predicting response to platinum-based therapy." 04/01/2015 - "This review summarizes the current status of first-line treatment of metastatic urothelial carcinoma in platinum-eligible patients as well as prognostic and predictive models in this disease. " 01/01/2015 - "Platinum-based combination therapy is the standard first-line treatment for women with advanced serous epithelial ovarian carcinoma (EOC). " 04/01/2003 - "To estimate the antitumor efficacy of dolastatin-10 in patients with measurable recurrences of platinum-sensitive ovarian carcinoma and to determine the nature and degree of toxicity of dolastatin-10 in these patients. " 01/01/2015 - "However, previous studies have revealed that some histological subtypes, such as clear cell carcinoma, are resistant to medical treatment, including that with platinum drugs. "
5.	Lung Neoplasms (Lung Cancer) 05/01/2009 - ": Although platinum-based combinations are considered the best option of care for patients with advanced nonsmall cell lung cancer (NSCLC), single-agent therapy is the preferred treatment for older patients. " 02/01/2002 - "These agents may be particularly useful in the treatment of lung cancer, both as adjunctive therapy in early-stage or locally advanced disease, as well as in combination strategies with platinum-based therapy in metastatic disease. " 09/22/2015 - "Our previous study identified that it was correlated with platinum response in lung cancer. " 03/01/2014 - "Confocal fluorescence microscopy was used to study a platinum-based anticancer agent in intact NCI-H460 lung cancer cells. " 01/01/2013 - "The large LUX-Lung 3 phase III trial recently reported afatinib to be clearly superior over the most effective platinum doublet in patients with EGFR mutation-positive lung cancer. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Paclitaxel (Taxol)
3.	Carboplatin (JM8)
4.	gemcitabine
5.	docetaxel (Taxotere)
6.	taxane
7.	oxaliplatin (Eloxatin)
8.	pemetrexed (MTA)
9.	bevacizumab
10.	Fluorouracil (Carac)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Radiotherapy
4.	Adjuvant Chemotherapy
5.	Heterologous Transplantation (Xenotransplantation)