Platinum

A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".

Also Known As:

Networked: 17370 relevant articles (2001 outcomes, 3641 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Scambia, Giovanni: 87 articles (01/2022 - 01/2003)
2.	Vergote, Ignace: 85 articles (10/2022 - 01/2003)
3.	Sehouli, Jalid: 82 articles (01/2022 - 06/2003)
4.	Colombo, Nicoletta: 66 articles (10/2022 - 01/2003)
5.	Coleman, Robert L: 64 articles (12/2022 - 01/2002)
6.	Markman, Maurie: 59 articles (07/2019 - 02/2002)
7.	Zhang, Wei: 53 articles (03/2022 - 08/2004)
8.	Matulonis, Ursula A: 51 articles (01/2022 - 09/2003)
9.	Ray-Coquard, Isabelle: 50 articles (01/2022 - 03/2003)
10.	Monk, Bradley J: 49 articles (12/2022 - 11/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "While platinum-based chemotherapeutic regimens have proven effective against highly proliferative malignant tumors, significant relapse and progression rates as well as decreased overall survival are still observed. " 09/01/2011 - "Cis-platin and other platinum complexes are important chemotherapeutic agents useful in the treatment of several cancers. " 05/01/2008 - "However, after 2 to 3 months of complete remission following platinum treatment, tumors relapse and become refractory to successive rounds of treatment. " 06/01/1976 - "Cis-chloroammine complexes of platinum have also been proven effective as a treatment for several animal tumors. " 01/01/2020 - "Regression analysis confirmed that there was a significant positive association between the M1/M2 ratio and an improved OS, PFS and platinum-free interval (PFI), both in the entire population and in patients stratified according to tumor type and initial surgery. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2014 - "Following elderly ovarian cancer patients over a lifetime using real-world longitudinal data and adjusting for quality of life, we found that treatment with platinum-based regimen was the most cost-effective treatment alternative." 03/17/2017 - "Both viruses are potent against a panel of platinum-resistant ovarian cancer cell lines and are attenuated on normal cells in vitro, resulting in therapeutic windows of ∼200-fold. " 02/28/2013 - "In women with platinum-sensitive recurrent ovarian cancer, ability to achieve surgery with complete cytoreduction (no visible residual disease) is associated with significant improvement in overall survival. " 01/01/1993 - "Platinum-containing regimens are very effective in the primary treatment of ovarian cancer. " 10/01/2021 - "Notably, the SWI/SNF CNAs were associated with homologous recombination deficiency (HRD) and improved clinical outcomes of platinum-treated ovarian cancer. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/01/2019 - "Despite recent progress, non-small cell lung cancer (NSCLC) first-line treatment remains a platinum-based doublet in most cases. " 01/01/2022 - "In ORIENT-11, first-line sintilimab + pemetrexed-platinum significantly improved PFS compared with placebo + pemetrexed-platinum in patients with advanced metastatic nonsquamous non-small-cell lung cancer (AMnsqNSCLC). " 01/01/2018 - "High Platelet Levels Attenuate the Efficacy of Platinum-Based Treatment in Non-Small Cell Lung Cancer." 08/01/2007 - "Third-generation platinum-based combinations are established as first-line treatment for advanced non-small cell lung cancer (NSCLC). " 07/01/2020 - "This study aimed to investigate the efficacy of platinum drugs in the treatment of elderly patients with advanced non-small cell lung cancer (NSCLC) and their effects on prognosis and survival. "
4.	Carcinoma (Carcinomatosis) 01/01/2020 - "Patients with platinum-sensitive carcinoma, treated with BEV, had a significant improvement in OS and extended PFS. " 01/01/2016 - "High-grade serous carcinomas with homologous recombination mutations were six times more likely to be associated with non-classic histology (P=0.002) and were significantly more likely to be platinum sensitive and have improved progression-free survival (PFS) (P=0.007 and P=0.004, respectively). " 09/27/2016 - "As DC treatment did not reveal better outcome, C or D single-agent might be an option in platinum-failed patients with advanced urothelial carcinoma. " 11/30/2023 - "Platinum ineligibility and survival outcomes in patients with advanced urothelial carcinoma receiving first-line treatment." 01/01/2022 - "Our results suggest that platinum-based AC is associated with improved DFS and a modest OS benefit in patients with locally advanced urothelial carcinomas."
5.	Ovarian Epithelial Carcinoma 01/01/2016 - "The best treatment for relapsed platinum sensitive epithelial ovarian cancer (EOC) is controversial. " 02/01/2015 - "This study confirmed that laparoscopy could be effective for the selection of platinum-sensitive recurrent epithelial ovarian cancer patients suitable for complete cytoreduction." 12/01/2021 - "To identify clinicopathologic factors predictive of early relapse (platinum-free interval (PFI) of ≤6 months) in advanced epithelial ovarian cancer (EOC) in first-line treatment, and to develop and internally validate risk prediction models for early relapse. " 01/04/2021 - "Early clearance of serum HE4 and CA125 in predicting platinum sensitivity and prognosis in epithelial ovarian cancer." 11/01/2023 - "To study the prognostic value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and platelet count in patients with platinum-sensitive recurrent epithelial ovarian cancer (PS-ROC). "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Paclitaxel (Taxol)
3.	Carboplatin (JM8)
4.	Bevacizumab (Avastin)
5.	Gemcitabine
6.	taxane
7.	Pemetrexed (MTA)
8.	Etoposide (VP 16)
9.	Fluorouracil (Carac)
10.	Oxaliplatin (Eloxatin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Radiotherapy
5.	Immunotherapy