Chylomicrons

A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.

Networked: 314 relevant articles (22 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yamashita, Shizuya: 8 articles (01/2014 - 06/2007)
2.	Maranhão, Raul C: 6 articles (03/2014 - 02/2003)
3.	Maranhão, R C: 6 articles (03/2007 - 02/2000)
4.	Vaziri, Nosratola D: 5 articles (04/2014 - 03/2005)
5.	Masuda, Daisaku: 5 articles (01/2014 - 11/2009)
6.	Tso, Patrick: 3 articles (04/2015 - 03/2011)
7.	Watts, Gerald F: 3 articles (01/2015 - 02/2003)
8.	Santos, Raul D: 3 articles (03/2014 - 02/2004)
9.	Hanada, Hiroyuki: 3 articles (01/2014 - 11/2009)
10.	Nishida, Makoto: 3 articles (01/2014 - 09/2011)

Related Diseases

1.	Hypertriglyceridemia 02/01/1981 - "A few obese, hypothyroid patients with fasting hypertriglyceridemia had low clearance of chylomicrons, which may have been due in part to competition for removal of excess endogenous TG. " 02/01/1981 - "In hypothyroid patients without hypertriglyceridemia, clearance of chylomicrons was normal. " 11/01/2010 - "This observation suggests that naked chylomicrons may be deposited in the dermis of patients with severe hypertriglyceridemia." 02/01/2002 - "The chylomicronemia syndrome is a disorder characterized by severe hypertriglyceridemia and massive accumulation of chylomicrons in plasma. " 01/01/1992 - "Another group of TA-3090-treated animals was given an intraduodenal fat meal, and the rise in plasma TG and chylomicrons followed over 4 hr. Postprandial hypertriglyceridemia and chylomicronemia were significantly lower at 2 hr (P less than 0.05) and 3 hr (P less than 0.01) compared with controls. "
2.	Hyperlipidemias (Hyperlipidemia) 01/01/2012 - "Ablation of Ces1/Es-x expression results in postprandial hyperlipidemia due to increased secretion of chylomicrons. " 02/01/2010 - "Type V hyperlipidemia (HTG V) characterized by accumulation of both chylomicrons and VLDL results from a complex combination of genetic and environmental factors. " 06/01/2006 - "Therefore, the elevated postprandial lipemia found in men compared with women was due to a prolonged availability of the lipid in chylomicrons, but was not related to differences in oxidation rates or incorporation of the ingested lipid into VLDL by the liver." 02/28/2006 - "In contrast, type IIb hyperlipidemia usually doesn't have increased chylomicrons. " 12/01/1998 - "When added to a fat load more or less specific labeling of chylomicrons and their remnants can be expected and this allows to approach the mechanism of postprandial lipemia from a new sight of view. "
3.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/1994 - "Twelve cases of chylous ascites (defined by the presence of chylomicrons) among 230 patients with chronic renal failure treated in two peritoneal dialysis centers (Limoges and Saint-Pierre de la Réunion) are reported. " 04/01/2012 - "Chronic renal failure (CRF) is associated with hypertriglyceridemia and impaired clearance of very low density lipoprotein (VLDL) and chylomicrons which are largely due to lipoprotein lipase (LPL) deficiency/dysfunction. " 12/01/1996 - "Chronic renal failure (CRF) is associated with hypertriglyceridemia, impaired clearance of very low density lipoproteins (VLDL) and chylomicrons and their remnants as well as triglyceride-enrichment of various lipoproteins. " 03/01/2005 - "Chronic renal failure (CRF) is associated with premature atherosclerosis, impaired high-density lipoprotein (HDL)-mediated reverse cholesterol transport, depressed clearance, and elevated plasma concentrations of very low-density lipoprotein (VLDL), chylomicrons, and their atherogenic remnants. " 01/01/2011 - "Lipid abnormalities in end-stage renal disease are characterized by: (a) reduced serum apoA-1 and high-density lipoprotein (HDL) concentrations, impaired HDL maturation and defective HDL antioxidant, anti-inflammatory and reverse cholesterol transport properties; (b) impaired clearance of very low-density lipoprotein and chylomicrons by the muscle and adipose tissue and of their remnants by the liver leading to hypertriglyceridemia, accumulation of intermediate-density lipoprotein and chylomicron remnants, and (c) oxidative modification of LDL and lipoprotein remnants favored by their structural abnormalities, oxidative stress, and impaired HDL antioxidant activity. "
4.	Obesity 01/01/2010 - "The lipid content of the chylomicrons is a key biomarker and risk factor of cardiovascular diseases and for the understanding of obesity. " 06/01/2008 - "The treatment of lymph node cells with free fatty acids, oxidative stress, and chylomicrons, which are obesity-related factors, resulted in lymph node T-cell activation and apoptosis. " 09/01/2002 - "Chylomicrons carry dietary fats in the bloodstream for storage in body tissues, and thus play an important role in obesity. " 07/01/1997 - "Too great a release into the general circulation because of diminished trapping of fatty acids released from chylomicrons appears to be critical in the pathogenesis of the dyslipoproteinaemias associated with hyperapo B or FCHL and omental obesity. " 03/01/2001 - "The knowledge about the molecular assembly of chylomicrons may lead to better therapeutic agents for controlling various hyperlipidemias, obesity, and atherosclerosis."
5.	Nephrotic Syndrome (Syndrome, Nephrotic) 04/01/2005 - "Nephrotic syndrome (N-S) is associated with elevated plasma concentration and impaired clearance of VLDL, chylomicrons (CM), and their atherogenic remnants. " 05/01/2005 - "Nephrotic syndrome is characterized by increased triglycerides resulting from decreased clearance of VLDL and chylomicrons. " 12/01/2001 - "It is unknown (1) whether the structure of secreted lipoproteins is normal before exposure to nephrotic syndrome serum and (2) whether the same structural or functional defects are imparted to chylomicrons (CMs) through their interaction with HDL from nephrotic syndrome rats. " 07/01/1993 - "Catabolism of triglyceride-rich lipoproteins, including chylomicrons (CM), is reduced in the nephrotic syndrome. " 04/17/1990 - "Experimental nephrotic syndrome: removal and tissue distribution of chylomicrons and very-low-density lipoproteins of normal and nephrotic origin."

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Chylomicron Remnants
3.	Lipoprotein Lipase (Diacylglycerol Lipase)
4.	Cholesterol
5.	VLDL Lipoproteins
6.	Lipase (Acid Lipase)
7.	Triglycerides (Triacylglycerol)
8.	Apolipoproteins B (ApoB)
9.	LDL Receptors (LDL Receptor)
10.	Apolipoprotein B-48

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)
2.	Catheters
3.	Peritoneal Dialysis
4.	Enteral Nutrition (Feeding, Tube)
5.	Blood Component Removal (Apheresis)