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Butylhydroxybutylnitrosamine

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A substituted carcinogenic nitrosamine.

Also Known As:

Butylbutanolnitrosamine; N-Butyl-N-(4-hydroxybutyl)nitrosamine; N-Nitroso-N-butyl-(4-hydroxybutyl)amine; N-Nitrosobutyl-4-hydroxybutylamine; N Nitrosobutyl 4 hydroxybutylamine; 1-Butanol, 4-(butylnitrosoamino)-

Networked: 100 relevant articles (2 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Nitroso Compounds: 319
  - Nitrosamines: 522
    - Butylhydroxybutylnitrosamine: 100

Experts

1.	Fukushima, S: 2 articles (12/2001 - 01/2000)
2.	Wanibuchi, H: 2 articles (12/2001 - 01/2000)
3.	Yamamoto, S: 2 articles (12/2001 - 01/2000)
4.	Scherr, Douglas S: 1 article (02/2014)
5.	Qiu, Xiaofeng: 1 article (01/2014)
6.	Guo, Yafang: 1 article (01/2014)
7.	Feng, Jun: 1 article (01/2014)
8.	Fei, Pingxia: 1 article (01/2014)
9.	Gao, Hua: 1 article (01/2014)
10.	Zheng, Ping: 1 article (01/2014)

Related Diseases

1.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/1990 - "The study was concerned with the effect of forced diuresis on the frequency and morphologic pattern of bladder cancer induced with butylbutanolnitrosamine in rats. " 03/01/2003 - "In animal experiments, electrogene transfer of HSVtk into N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced rat bladder tumors was conducted followed by GCV administration. " 01/01/1998 - "Treatment of C57BL/6 J (B6) and NON male mice with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) resulted in a high incidence of bladder cancer. " 01/01/1997 - "Bladder tumors were induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in five Beagles and four mongrel dogs. " 01/01/1991 - "Bladder cancer was induced in male B6D2F1 strain mice by the administration of N-butyl-N-(4-hydroxybutyl)nitrosamine. "
2.	Carcinoma (Carcinomatosis) 10/01/2004 - "We investigated gene expression in N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced rat bladder carcinoma in order to test its applicability as a model for the study of novel therapeutic modalities, particularly gene therapy. " 12/01/1998 - "This study was designed to investigate the dynamics of the expression of H19 in the mouse bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) and its relation to stages of neoplastic transformation. " 01/01/1986 - "Studies were performed on the susceptibilities of various strains of mice to induction of bladder carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN), and the type of carcinomas that developed. " 07/01/2002 - "We used the model of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN, 0.05% via drinking water x10 weeks) to induce superficial bladder carcinomas in 40 female rats. " 04/01/1999 - "We have previously reported that they are also frequent in invasive urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in NON/Shi mice. "
3.	Neoplasms (Cancer) 01/01/1997 - "A histopathological mapping study of the urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in dogs." 06/01/2001 - "Urinary bladder tumors were induced with a selective carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. " 09/01/1998 - "We have investigated the susceptibility of heterozygote p53 knockout mice to N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in terms of urinary bladder tumor induction. " 05/01/1997 - "In the first experiment, 83 male F344 rats were all given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 wk and then divided into 5 groups, which received basal diet (Oriental MF) containing AsA at 0, 1, 2, 3.5, or 5% plus 1.5% NaHCO3 for 32 wk. Relative urinary bladder weights in the 5% AsA group were significantly increased as compared to the 0 or 1% group values due to the development of tumors. " 01/01/1992 - "In order to ascertain whether this difference in cancer incidence between nude and B6C3F1 mice was due to variation in urinary excretion, the metabolism of EHBN was also investigated and compared with that of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). "
4.	Transitional Cell Carcinoma 01/01/1994 - "This study describes ultrastructural alterations in the basement membrane (BM) of rat bladder with invasive transitional cell carcinoma (TCC) induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. " 01/01/1979 - "A quantitative dosing schedule for the induction of transitional cell carcinomas in female F344 rats with the use of N-butyl-N-(4-hydroxybutyl)nitrosamine." 11/18/1977 - "Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. " 01/01/1994 - "Basement membrane and tumor invasion: ultrastructural observations in the basement membrane of rat bladder with invasive transitional cell carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine." 10/01/1991 - "In this study, we examined the possible mutational activation of neu oncogene in 50 urinary bladder transitional cell carcinomas (TCC) induced in F344 rats by the following carcinogenesis models: (i) 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) (4 weeks)----3% uracil (20 weeks); (ii) 0.2% N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) (6 weeks)----5% sodium saccharin (72 weeks); and (iii) N-methyl-N-nitrosourea (MNU) 20 mg/kg body wt, i.p. "
5.	Hyperplasia 05/15/1991 - "K2CO3 dose dependently increased the numbers of the putative preneoplastic lesion, papillary or nodular hyperplasia, and papillomas in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. " 11/01/1980 - "Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine." 10/01/1980 - "The effect of cyclophosphamide (CP) on the urinary bladder epithelium of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was examined histologically to detect preneoplastic papillary or nodular hyperplasia. " 05/01/2011 - "Male Wistar rats were treated with 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in drinking water, which caused flat hyperplasia with mild dysplasia, low-grade papillary urothelial carcinoma, invasive low- and high-grade papillary urothelial carcinoma and invasive squamous cell carcinoma with extensive keratinization, grade 2. During urothelial carcinogenesis, UPII expression was the most decreased in all urothelial lesions, while UPIa, UPIb, and UPIIIa expression was differently altered in different types of lesions. " 06/01/1988 - "Chronological changes in nonspecific esterase (NSE) activity in hyperplasia of the bladder mucosa in Wistar rats induced by the administration of 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in their drinking water for up to 20 weeks and in reversible regenerative hyperplasia by freeze ulceration and 20% formalin instillation in the bladder were compared. "

Related Drugs and Biologics

1.	hydroxide ion
2.	Piroxicam (Feldene)
3.	beta Carotene (Betacarotene)
4.	lycopene
5.	Sodium
6.	Uracil
7.	Methylnitrosourea (N-Methyl-N-nitrosourea)
8.	Saccharin
9.	Protease Inhibitors (Protease Inhibitor)
10.	FANFT

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Oral Administration
3.	Intravesical Administration
4.	Intraperitoneal Injections
5.	Hyperbaric Oxygenation