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N-ethyl-N-(4-hydroxybutyl)nitrosamine

rapid & selective inducer of urinary bladder cancer in rats

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitroso Compounds: 446
  - Nitrosamines: 1539
    - Butylhydroxybutylnitrosamine: 213
      - N-ethyl-N-(4-hydroxybutyl)nitrosamine: 7

Related Diseases

1.	Carcinogenesis 01/01/1992 - "A time- and dose-dependent study of N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) bladder carcinogenesis was performed in nude mice maintained on tap water containing 0.025% EHBN for 4, 12, and 20 weeks ad libitum. " 06/01/1991 - "A sequential investigation of N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) bladder carcinogenesis was performed in male B6C3F1 mice maintained ad libitum on tap water containing 0.025% EHBN for 4, 12, 20, 28 and 36 weeks. " 10/01/1991 - "The post-initiation enhancing activities of the non-genotoxic agent NaHCO3 and the genotoxic agent N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) in combination with uracil-induced urolithiasis were investigated in a rat bladder carcinogenesis model. "
2.	Neoplasms (Cancer) 01/01/1992 - "Low susceptibility of nude mice to induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine." 06/01/1991 - "Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice." 04/01/1976 - "Hamsters were far less susceptible than mice, and cancer developed only in 3 of 41 animals given N-ethyl-N-(4-hydroxybutyl)nitrosamine. " 06/30/1988 - "Combined effects of L-ascorbic acid, citric acid or their sodium salts on tumor induction by N-butyl-N-(4-hydroxybutyl)nitrosamine or N-ethyl-N-(4-hydroxybutyl)nitrosamine in the rat urinary bladder."
3.	Urinary Bladder Neoplasms (Bladder Cancer) 04/01/1976 - "The urinary bladder epithelium of rats was the most susceptible to all three compounds, and especially to N-ethyl-N-(4-hydroxybutyl)nitrosamine, and bladder cancers developed in all the rats given this compound. " 11/01/1988 - "Treatment with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) or N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) in the drinking water induces bladder cancer of rats or mice with high incidence. "
4.	Urolithiasis 10/01/1991 - "The post-initiation enhancing activities of the non-genotoxic agent NaHCO3 and the genotoxic agent N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) in combination with uracil-induced urolithiasis were investigated in a rat bladder carcinogenesis model. "
5.	Carcinoma (Carcinomatosis) 10/01/1994 - "We also examined connexin expression in rat bladder carcinomas induced by 3,2'-dimethyl-4-aminobiphenyl or N-ethyl-N-(4-hydroxybutyl)nitrosamine (EHBN) and in normal bladders. "

Related Drugs and Biologics

1.	Butylhydroxybutylnitrosamine
2.	Drinking Water
3.	Citric Acid (Citrate)
4.	Connexins
5.	Uracil
6.	Sodium
7.	Salts
8.	Ascorbic Acid (Vitamin C)
9.	2',3-dimethyl-4-aminobiphenyl