13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Abstract

Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.

• Authors: C J Grubbs, R C Moon, R A Squire, G M Farrow, S F Stinson, D G Goodman, C C Brown, M B Sporn
• Journal: Science (New York, N.Y.) (Science) Vol. 198 Issue 4318 Pg. 743-4 (Nov 18 1977) ISSN: 0036-8075 [Print] United States
• PMID: 910158 (Publication Type: Journal Article)

Chemical References

• Nitrosamines
• Vitamin A
• Butylhydroxybutylnitrosamine
• Tretinoin

Topics

• Animals
• Butylhydroxybutylnitrosamine
• Carcinoma, Transitional Cell (chemically induced, drug therapy, prevention & control)
• Male
• Neoplasms, Experimental (chemically induced, drug therapy, prevention & control)
• Nitrosamines
• Rats
• Rats, Inbred F344
• Tretinoin (therapeutic use)
• Urinary Bladder Neoplasms (chemically induced, drug therapy, prevention & control)
• Vitamin A (analogs & derivatives)