[Effects of forced diuresis on butylbutanolnitrosamine induction of bladder tumors in rats].

Abstract

The study was concerned with the effect of forced diuresis on the frequency and morphologic pattern of bladder cancer induced with butylbutanolnitrosamine in rats. An 1.6 times increase in diuresis was followed by inhibition of bladder carcinogenesis, resulting in a 2.5-fold decrease in the tumor rate as compared to controls. The data obtained confirm the earlier suggested hypothesis of "urothelial contact" as well as epidemiologic data.

• Authors: G B Pliss, A G Frolov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 36 Issue 1 Pg. 33-6 ( 1990) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Vliianie forsirovannogo diureza na induktsiiu opukholeĭ mochevogo puzyria u krys butilbutanolnitrozaminom.
• PMID: 2305560 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Nitrosamines
• Butylhydroxybutylnitrosamine

Topics

• Animals
• Butylhydroxybutylnitrosamine
• Carcinoma (chemically induced, pathology)
• Diuresis
• Hyperplasia
• Nitrosamines
• Papilloma (chemically induced, pathology)
• Rats
• Time Factors
• Urinary Bladder (pathology)
• Urinary Bladder Neoplasms (chemically induced, pathology)