Benzalkonium Compounds (Benzalkonium Chloride)

A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.

Also Known As:

Networked: 300 relevant articles (20 outcomes, 41 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Baudouin, Christophe: 6 articles (01/2015 - 12/2003)
2.	Kahook, Malik Y: 6 articles (06/2014 - 01/2009)
3.	Ammar, David A: 4 articles (01/2013 - 11/2010)
4.	Goldberg, Ivan: 3 articles (04/2015 - 01/2012)
5.	Pescosolido, Nicola: 3 articles (09/2013 - 12/2011)
6.	Noecker, Robert J: 3 articles (06/2011 - 07/2004)
7.	Wallengren, J: 3 articles (12/2002 - 09/2000)
8.	Teranishi, Shinichiro: 2 articles (08/2015 - 04/2015)
9.	Kiuchi, Yoshiaki: 2 articles (04/2015 - 12/2010)
10.	Kanamoto, Takashi: 2 articles (04/2015 - 12/2010)

Related Diseases

1.	Infection 09/01/2010 - "We conducted dose-response studies in mice using 2%, 0.2%, or 0.02% benzalkonium chloride (BZK) as the test compound, and using multiple safety end points that included endoscopic colposcopy, susceptibility to vaginal HSV-2 infection, histology, and entry of inflammatory cells into the vagina. " 01/01/2015 - "The genus Methylobacterium tolerates hygiene agents like benzalkonium chloride (BAC), and infection with this organism is an important public health issue. " 11/01/2009 - "To investigate the in vitro effects of benzalkonium chloride (BAK) at various concentrations and dosing schedules on adenoviral infection. " 03/01/2008 - "Hospital-acquired Burkholderia cepacia infection related to contaminated benzalkonium chloride." 03/01/2006 - "On this basis we evaluated the antimicrobial activity of benzalkonium chloride against GBS, which has been described as an antimicrobial agent for the topical treatment of vaginal infections. "
2.	Glaucoma 01/01/2012 - "A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits." 06/01/2011 - "The aim of this study is to investigate potential adverse effects of fixed combination glaucoma medications preserved with either benzalkonium chloride (BAK) or Polyquad® (PQ; Alcon Research Ltd., Fort Worth, TX, USA) on cultured ocular epithelial cells. " 04/01/2015 - "OSD symptoms could be linked to prolonged exposure to preservatives in anti-glaucoma medications, especially benzalkonium chloride (BAK). " 04/01/2015 - "Clinical audit examining the impact of benzalkonium chloride-free anti-glaucoma medications on patients with symptoms of ocular surface disease." 06/01/2014 - "[Preservative substances - the daily dose of benzalkonium chloride in glaucoma treatment from the patients point of view]."
3.	Ocular Hypertension (Glaucoma, Suspect) 05/01/2012 - "Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: a randomized clinical trial." 12/01/2013 - "Meta analysis about the efficacy and safety of anti-ocular hypertension eye drops without benzalkonium chloride." 12/01/2013 - "To explore the safety and efficacy of eye drops without benzalkonium chloride (BAK) in treating glaucoma and ocular hypertension. " 01/01/2007 - "To compare the safety and efficacy of travoprost 0.004% without benzalkonium chloride (BAC) to that of the marketed formulation of travoprost 0.004% in patients with open-angle glaucoma or ocular hypertension. " 04/01/1995 - "The purpose of this study was to assess whether the preservative benzalkonium chloride (BAC 0.01%) present in timolol induced a decrease in basal tear turnover and a deterioration of precorneal tear film in patients with glaucoma and ocular hypertension using topical timolol. "
4.	Wounds and Injuries (Trauma) 01/01/1998 - "This study shows that benzalkonium chloride is more effective than normal saline as an irrigating agent for eradicating Staphylococcus aureus from a contaminated orthopaedic wound." 01/01/1998 - "The efficacy of benzalkonium chloride was evaluated as an irrigating solution for the eradication of Staphylococcus aureus from a contaminated orthopaedic wound. " 01/01/2011 - "The effects due to the presence of benzalkonium chloride (BAK) were also studied on cell cultures, ex vivo on rabbit isolated corneas, evaluating the hydration level, and on the healing rate of experimental corneal wounds in rabbits. " 01/01/1998 - "The wound was irrigated with 1 L of normal saline or 0.1% benzalkonium chloride solution. " 08/01/1997 - "The remaining four eyes from the 1.5mm group were rinsed with 0.02% Benzalkonium Chloride on an epithelial wound. "
5.	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/01/2015 - "A total of 18 patients treated for primary open-angle glaucoma with benzalkonium chloride (BAK) preserved eye drops and eight age-matched controls were included in this study. " 03/01/2014 - "Here, we prospectively investigated the incidence and factors associated with DUES in Japanese open-angle glaucoma patients initially treated with benzalkonium chloride (BAK)-preserved tafluprost (TAF). " 01/01/2007 - "To compare the safety and efficacy of travoprost 0.004% without benzalkonium chloride (BAC) to that of the marketed formulation of travoprost 0.004% in patients with open-angle glaucoma or ocular hypertension. " 08/01/2015 - "In patients with open-angle glaucoma or ocular hypertension, polyquaternium-1-preserved travoprost 0.003% solution provided equivalent IOP-lowering efficacy to that of benzalkonium chloride-preserved travoprost 0.004%." 08/01/2015 - "To demonstrate equivalence of polyquaternium-1-preserved travoprost 0.003% with benzalkonium chloride-preserved travoprost 0.004% in patients with open-angle glaucoma or ocular hypertension. "

Related Drugs and Biologics

1.	travoprost (Travatan)
2.	Povidone-Iodine (Betadine)
3.	chlorhexidine gluconate (Dyna-Hex)
4.	Timolol (Blocadren)
5.	latanoprost (Xalatan)
6.	Soaps (Soap)
7.	Ophthalmic Solutions (Eye Drops)
8.	Heparin (Liquaemin)
9.	Nonoxynol (Nonoxynol 9)
10.	Disinfectants

Related Therapies and Procedures

1.	Catheters
2.	Drug Therapy (Chemotherapy)
3.	Denervation
4.	Injections
5.	Nebulizers and Vaporizers (Inhaler)