HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Open-Angle Glaucoma (Glaucoma, Open Angle)

Subscribe to New Research on Open-Angle Glaucoma

Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.

Also Known As:

Glaucoma, Open Angle; Pigmentary Glaucoma; Glaucoma, Open-Angle; Glaucoma, Compensated; Glaucoma, Compensative; Compensated Glaucoma; Compensated Glaucomas; Compensative Glaucoma; Compensative Glaucomas; Glaucomas, Compensated; Glaucomas, Compensative; Glaucomas, Open Angle; Glaucomas, Open-Angle; Glaucomas, Pigmentary; Glaucomas, Simple; Open Angle Glaucoma; Open Angle Glaucomas; Open-Angle Glaucomas; Pigmentary Glaucomas; Simple Glaucoma; Simple Glaucomas; Simplex, Glaucoma; Simplices, Glaucoma; Glaucoma Simplex; Glaucoma, Pigmentary; Glaucoma, Simple

Networked: 3896 relevant articles (305 outcomes, 697 trials/studies)

Relationship Network

Disease Context: Research Results

Eye Diseases: 2132
- Ocular Hypertension: 1905
  - Glaucoma: 13524
    - Open-Angle Glaucoma: 3896
      - Hydrophthalmos: 48

Related Diseases

1.	Ocular Hypertension (Glaucoma, Suspect)
2.	Glaucoma
3.	Cataract (Cataracts)
4.	Open-Angle Glaucoma (Glaucoma, Open Angle)
5.	Low Tension Glaucoma

Experts

1.	Stewart, William C: 33 articles (01/2013 - 05/2002)
2.	Pasquale, Louis R: 25 articles (07/2015 - 08/2003)
3.	Stewart, W C: 25 articles (05/2009 - 02/2000)
4.	Weinreb, Robert N: 23 articles (11/2015 - 03/2004)
5.	Araie, Makoto: 21 articles (11/2015 - 01/2002)
6.	Harris, Alon: 21 articles (06/2015 - 03/2002)
7.	Konstas, Anastasios G P: 19 articles (10/2014 - 06/2002)
8.	Stewart, Jeanette A: 19 articles (01/2013 - 05/2002)
9.	Wiggs, Janey L: 18 articles (07/2015 - 01/2002)
10.	Craig, Jamie E: 17 articles (08/2015 - 02/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Open-Angle Glaucoma:

1.	Timolol (Blocadren)FDA LinkGeneric 09/01/1979 - "Timolol maleate appears to be effective and well tolerated when administered with other antiglaucoma medications in patients with open-angle glaucoma." 10/01/2005 - "The aim of this study was to determine the effectiveness of timolol gel-forming solution as a monotherapy and to compare the efficacy of timolol gel-forming solution morning instillation versus at night application in Asians with newly diagnosed open-angle glaucoma. " 01/01/1998 - "The efficacy of timoptic depot is assessed in 20 patients with open-angle glaucoma, previously treated with 0.25 and 0.5% timolol. " 10/01/2012 - "The study was undertaken to measure the effects of Beta blocker (Timolol maleate 0.5%) in moderate and advanced stage of primary open angle glaucoma by controlling intra-ocular pressure (IOP) and assessing the visual acuity (VA) and mean sensitivity (MS) of visual field. " 10/01/2009 - "Twenty-five patients with primary open-angle glaucoma (POAG) who were treated with topical timolol 0.5% were included in the study. "
2.	latanoprost (Xalatan)FDA Link 11/01/2002 - "To assess the efficacy of latanoprost as additive therapy in patients with open-angle glaucoma and an intraocular pressure (IOP) deemed to be too high on maximum tolerated medical therapy. " 12/01/2003 - "Latanoprost monotherapy is a safe and effective alternative for many patients with open angle glaucoma requiring dual topical ocular hypotensive therapy for IOP control." 03/01/2008 - "First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study." 06/16/2015 - "In open-angle glaucoma, latanoprost improved visual field preservation." 05/01/2002 - "[Efficacy of latanoprost monotherapy treatment in primary open-angle glaucoma]."
3.	dorzolamide (Trusopt)FDA LinkGeneric 04/01/2002 - "Forty-seven patients with open angle glaucoma were consecutively randomized to dorzolamide versus placebo TID during a 6-week double-masked treatment trial. " 10/01/2007 - "To evaluate progression rates with dorzolamide compared with other hypotensive agents in primary open-angle glaucoma. " 08/01/2004 - "We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma. " 04/01/2000 - "Most patients in each group were white, had open-angle glaucoma, and were being treated with a nonselective beta-blocker and dorzolamide. " 07/01/2009 - "Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma."
4.	travoprost (Travatan)FDA Link 10/01/2014 - "The present study demonstrated the long-term 24-hour efficacy of travoprost for the treatment of primary open-angle glaucoma." 10/01/2014 - "The aim of the study was to evaluate the long-term 24-hour intraocular pressure (IOP) efficacy of travoprost monotherapy in primary open-angle glaucoma patients. " 04/01/2009 - "This study suggests that when both drugs are dosed in the evening the TTFC provides improved intraocular pressure reduction, compared with travoprost, over the 24 h curve and for each individual time point in primary open-angle glaucoma patients." 12/01/2004 - "Effects of travoprost 0.004% ophthalmic solution, six weeks after its laminated packaging had been removed, in primary open-angle glaucoma: a randomized, controlled, investigator-blinded study." 10/01/2014 - "Long-term 24-hour intraocular pressure control with travoprost monotherapy in patients with primary open-angle glaucoma."
5.	bimatoprost (Lumigan)FDA Link 11/01/2009 - "Pharmacoeconomic data indicate that bimatoprost is cost effective in the treatment of open-angle glaucoma." 07/01/2009 - "A 12-week study evaluating the efficacy of bimatoprost 0.03% in patients with pseudoexfoliative and open-angle glaucoma." 08/01/2007 - "Comparative evaluation of bimatoprost monotherapy in primary chronic angle closure and primary open angle glaucoma eyes: a three-year study." 05/01/2005 - "This study indicates that the intraocular pressures are lowered to a statistically similar amount with DTFC compared to bimatoprost in open-angle glaucoma and ocular hypertensive patients." 10/01/2004 - "A drug utilization trial was performed to investigate acute versus short-term effects after switching or adding bimatoprost in open-angle glaucoma patients over a 3- month observation period. "
6.	brinzolamide (Azopt)FDA Link 01/01/2012 - "This study suggests that brinzolamide may be safely added to TTFC therapy to provide further significant reduction in IOP patients with ocular hypertensive or primary open-angle glaucoma." 05/01/2004 - "Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients." 02/01/2000 - "This study was performed to establish the long-term safety and efficacy of brinzolamide 1.0% two and three times daily for primary open-angle glaucoma and ocular hypertension. " 02/01/2000 - "The long-term safety and efficacy of brinzolamide 1.0% (azopt) in patients with primary open-angle glaucoma or ocular hypertension. " 01/01/2000 - "A multicenter, double-masked, placebo-controlled, parallel trial was conducted to evaluate the optimal intraocular pressure (IOP)-lowering concentration and ocular tolerability of topically administered brinzolamide (0.3%, 1%, 2%, and 3%) in patients with primary, open-angle glaucoma or ocular hypertension. "
7.	brimonidine (Alphagan)FDA LinkGeneric 09/01/2001 - "The purpose of this study was to report the acute and chronic effects of brimonidine 0.2% on intraocular pressure (IOP) and pulsatile ocular blood flow (pOBF) in patients with primary open-angle glaucoma (POAG). " 01/01/2015 - "A 78-year-old male with a history of primary open angle glaucoma presented with symptoms of unilateral blurry vision, irritation, and redness shortly after starting brimonidine exclusively in the right eye. " 04/01/2011 - "Sustained release ocular inserts of brimonidine tartrate for better treatment in open-angle glaucoma." 04/01/2004 - "To compare the efficacy and safety of unoprostone versus brimonidine both given twice daily in ocular hypertensive or primary open-angle glaucoma subjects. " 12/01/2003 - "Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients."
8.	ArgonIBA 01/01/1985 - "[Hypotensive effect of argon lasertrabeculospasis in the treatment of open-angle glaucoma]." 11/01/1982 - "[Treatment of chronic primary open angle glaucoma with argon laser trabeculo-retraction--preliminary study of 12 eyes]." 01/01/2010 - "Both Argon and Yag lasers are now-a-days commonly used in the treatment of angle-closure and open-angle glaucomas. " 01/01/2000 - "[Use of YAG-Selecta laser and argon laser in the treatment of open angle glaucoma]." 01/01/1991 - "After argon trabeculoplasty procedures in patients with chronic open angle glaucoma, the protein appearance and cell circulation were observed within the anterior chamber. "
9.	Mitomycin (Mitomycin-C)FDA LinkGeneric 03/01/2013 - "To evaluate the safety and preliminary efficacy of intraoperative mitomycin C (MMC) in conjunction with canaloplasty for the treatment of open-angle glaucoma. " 08/01/2002 - "To prospectively study and compare the effectiveness and the safety of primary deep sclerectomy with and without the use of mitomycin C in eyes with open-angle glaucoma. " 01/01/2011 - "Mitomycin C-enhanced primary DS effectively reduces IOP in primary phakic open-angle glaucoma. " 01/01/2011 - "Phacotrabeculectomy without mitomycin C in primary angle-closure and open-angle glaucoma." 12/01/2002 - "To evaluate the clinical effect of non-penetrating trabecular surgery (NPTS) with mitomycin C (MMC) in primary open-angle glaucoma (POAG). "
10.	Levobunolol (AKBeta)FDA LinkGeneric 01/01/1993 - "We treated both eyes of 38 African American patients who have stable open angle glaucoma with either levobunolol b.i.d. " 09/01/1982 - "Data from two short-term double-masked studies using 24 and 16 subjects suggest that topically applied levobunolol safely and effectively treats open-angle glaucoma and ocular hypertension. " 02/01/1988 - "The authors evaluated the efficacy of once-daily treatment with levobunolol in patients with primary open-angle glaucoma or ocular hypertension in an open-labeled, two-phase titration clinical trial. " 05/01/1992 - "Effects of a single instillation of levobunolol, a new nonselective beta-adrenoblocker, in normal subjects and patients with various forms of glaucoma were under study, as were the effects of prolonged administration of this drug in patients with open-angle glaucoma. " 05/01/2008 - "27 eyes of 27 patients were consecutively randomized to receive preserved or unpreserved levobunolol; all patients had a recent diagnosis of primary open angle glaucoma (POAG) or ocular hypertension and were not previously treated with topical medications. "

Therapies and Procedures

1.	Trabeculectomy (Trabeculoplasty) 12/01/1988 - "It appears that in cases of primary open angle glaucoma of this severity the risk of delaying operation are significantly greater than those of performing trabeculectomy as the primary treatment." 01/01/2004 - "NPDS appears to be an effective and safe filtering procedure for lowering IOP and could be an alternative to trabeculectomy in open angle glaucoma with the advantage of having fewer complications." 03/01/2015 - "Ab-interno trabeculotomy is a safe and effective method for treatment of patients with primary or secondary open angle glaucomas and moderate target pressures." 03/01/2014 - "Canaloplasty and trabeculectomy are safe and effective procedures in the treatment of open-angle glaucoma. " 01/01/2008 - "Trabeculotomy Ab Interno, using the Trabectome: a promising treatment for patients with open-angle glaucoma."
2.	Lasers (Laser) 04/01/1983 - "Another use of the laser: a new treatment for open-angle glaucoma." 01/01/2014 - "Despite advances in laser and microsurgical techniques, medical IOP reduction remains the first-line treatment option for the majority of patients with open-angle glaucoma. " 01/01/2014 - "The aim of the study reported here was to evaluate characteristics of the anterior-segment via anterior-segment optical coherence tomography (AS-OCT) and corneal biomechanical properties using an ocular response analyzer and their changes by peripheral laser iridotomy (PI) in patients with pigmentary glaucoma (PG). " 06/01/2013 - "In this study, we have used a laser-induced model of open angle glaucoma (OAG) to evaluate the potential of bone marrow cell populations and the mechanisms involved in tissue repair. " 03/01/2011 - "Of the 3280 participants in the study, 2525 (77.0%) right eyes with reliable confocal scanning laser tomography images were included in this analysis, with 48 eyes defined to have primary open-angle glaucoma (POAG). "
3.	Phacoemulsification 11/01/2015 - "The IOP lowering obtained by this combined surgery is significantly greater than that obtained after phacoemulsification alone in open-angle glaucoma. " 03/01/2015 - "Clear corneal phacoemulsification performed before or in combination with canaloplasty is a safe and effective surgical procedure to reduce IOP in adult patients with open-angle glaucoma." 07/01/2015 - "A Randomized Trial of a Schlemm's Canal Microstent with Phacoemulsification for Reducing Intraocular Pressure in Open-Angle Glaucoma." 01/01/2015 - "Micro-Bypass Implantation for Primary Open-Angle Glaucoma Combined with Phacoemulsification: 4-Year Follow-Up." 01/01/2015 - "We propose comparative assessment of the effectiveness of two surgical methods for the treatment of open-angle glaucoma: (1) ExPress mini-device implantation combined with phacoemulsification and (2) ExPress mini-device implantation alone. "
4.	Filtering Surgery 08/01/2002 - "In eyes with open-angle glaucoma, viscocanalostomy is less effective in reducing intraocular pressure than standard filtering surgery. " 12/01/1996 - "When intraocular pressure is used as a therapeutic end point, both filtration surgery and medical therapy appear to be equally effective in maintaining long-term visual function and a stable optic disk in chronic open-angle glaucoma." 12/01/2012 - "Thus, our prospective data do not support the procedure of IDK as 'the gold standard' for filtering surgery in patients with open-angle glaucoma." 01/01/2006 - "Retrospective non randomised study including 171 eyes (136 patients), mean age: 63.9 years) with medically uncontrolled open-angle glaucoma and without previous filtering surgery. " 02/01/2004 - "32 eyes of 32 primary open-angle glaucoma(POAG) patients who underwent NPT as the first filtering surgery were enrolled in the study. "
5.	Semiconductor Lasers 10/01/2013 - "Low-dose transscleral diode laser cyclophotocoagulation (TSCPC) as a potential single treatment for primary open-angle glaucoma (POAG) in Malawi?" 03/01/2001 - "In a prospective clinical trial in Cape Coast and Accra, Ghana, 1 eye of each of 92 patients with primary open-angle glaucoma was treated by diode laser TSCPC as a primary surgical treatment. " 03/01/2001 - "Diode laser transscleral cyclophotocoagulation as a primary surgical treatment for primary open-angle glaucoma." 03/01/2009 - "This study suggests that diode laser trabeculoplasty is an effective and safe mode of treatment for eyes with open-angle glaucoma, and its outcome may be predicted earlier than previously thought." 09/01/1998 - "Clinical efficacy of diode laser trabeculoplasty is assessed in 35 eyes of 30 patients with primary open-angle glaucoma during during the initial and well-developed stages of diseases. "