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Povidone-Iodine (Betadine)

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An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes.

Also Known As:

Betadine; PVP-I; Alphadine; Betaisodona; Disadine; Huntington Laboratories Brand of Povidone-Iodine; Isodine; Pharmadine; Providine; Alphadines; Betadines; Betaisodonas; Disadines; Huntington Laboratories Brand of Povidone Iodine; Isodines; PVP Iodine; PVP-Iodines; Pharmadines; Polyvinylpyrrolidone Iodines; Povidone Iodine; Povidone-Iodines; Providines; PVP-Iodine; Polyvinylpyrrolidone Iodine; 2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine

Networked: 1106 relevant articles (163 outcomes, 208 trials/studies)

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Drug Context: Research Results

Experts

1.	Kramer, A: 9 articles (08/2010 - 01/2000)
2.	Reimer, K: 9 articles (09/2008 - 01/2000)
3.	Mimoz, Olivier: 6 articles (11/2015 - 10/2007)
4.	Ta, Christopher N: 6 articles (01/2015 - 10/2004)
5.	Capriotti, Joseph A: 5 articles (12/2015 - 01/2011)
6.	Nentwich, Martin M: 5 articles (04/2015 - 07/2012)
7.	Kampik, Anselm: 5 articles (04/2015 - 07/2012)
8.	Wutzler, P: 5 articles (12/2006 - 03/2000)
9.	Vogt, P M: 5 articles (09/2006 - 01/2000)
10.	Fleischer, W: 5 articles (09/2006 - 01/2000)

Related Diseases

1.	Infection 01/01/1993 - "Clinical studies demonstrate that treatment with PVP-I is the most effective against bacterial and fungal infection. " 01/01/2015 - "OPB-2045G showed more potent bactericidal activity against MRSA and VRE both in vitro and in vivo compared to CHG and PVP-I, indicating that OPB-2045G may provide better protection against health care-associated infections caused by these pathogens. " 11/01/2002 - "After 1 week of treatment, povidone-iodine cured marginally more chlamydial infections than the antibiotic (P =.057). " 05/01/2014 - "Povidone-iodine soaks are not helpful in the postoperative management of hand infections Therapeutic II." 09/01/2011 - "We consider the solution of PVP-I plus H(2)O(2) effective in further reducing the rate of post-operative infection in spine surgery."
2.	Wounds and Injuries (Trauma) 06/01/2014 - "Honey dressing is highly effective in achieving healing in chronic wounds as compared to Povidone iodine dressing. " 12/01/2009 - "At the end of the study, there was a significant reduction in primary parameters such as wound area and microbial colony count in oxum treated group compared to betadine group. " 04/01/1979 - "The initiation of a supervised preventive program for 84 patients over 19 months which includes the regular swabbing of each axilla with povidone-iodine cotton sticks in addition to measures to avoid skin trauma has virtually eliminated inflammatory axillary lesions in this high risk patient population." 01/01/2015 - "The antimicrobial effect of PVP-iodine was strongly diminished with rising pH. The shift towards higher pH values in chronic wounds compared to acute wounds makes it imperative to know whether the antimicrobial efficacy of applied antimicrobial substances is altered by different pH levels. " 12/01/2009 - "Oxum has been shown to be effective, well tolerated and superior to betadine in wound care."
3.	Wound Infection (Wound Infections) 11/01/2013 - "There was a reduced incidence of groin wound infections in those randomized to Betadine (3 versus 1), but this was not statistically significant (P = 0.4). " 01/01/2006 - "Applying PVP-I was effective in eliminating skin contamination, as cultures became negative in all cases after applying PVP-I. However, this study could not demonstrate the reduction of wound infection or SSI in the group with PVP-I, possibly because the number of cases in this study was too small to make a difference. " 08/01/2005 - "The aim of this study was to evaluate the efficacy of dilute betadine solution in the prevention of wound infection after spinal surgery. " 08/01/2005 - "Our report is the first prospective, single-blinded, randomized study to evaluate the clinical effectiveness of dilute betadine solution irrigation for prevention of wound infection following spinal surgery. " 06/01/2002 - "The purpose of this study was to assess the influence of povidone-iodine mediastinal irrigation used for the treatment of deep sternal wound infection (DSWI) on thyroid function. "
4.	Cataract (Cataracts) 07/01/2009 - "Use of 5% povidone-iodine for 3 minutes prior to cataract surgery achieves a significant reduction in organisms such as CoNS from lid and conjunctival flora." 07/01/2009 - "To evaluate the efficacy of 3 minutes of 5% povidone-iodine for skin and conjunctival antisepsis prior to cataract surgery as recommended by the European Society of Cataract and Refractive Surgeons. " 04/01/2001 - "The disinfecting of the periocular skin with 10% povidone-iodine solution and of the conjunctiva with 5% povidone-iodine solution the day before and one hour before cataract surgery is effective in reducing conjunctival bacterial colonization compared with perioperative disinfection alone." 03/01/2012 - "This study aimed to evaluate the efficacy of povidone-iodine (PI) 5% as the only preoperative antiseptic in cataract surgery. " 07/01/2009 - "The efficacy of 5% povidone-iodine for 3 minutes prior to cataract surgery."
5.	Endophthalmitis (Ophthalmia) 03/01/2000 - "A 5% solution of PVP-I proved to be highly effective in ophthalmic surgery for the prophylaxis of endophthalmitis. " 01/01/2006 - "The postoperative endophthalmitis rate showed a significant reduction after introduction of povidone-iodine. " 12/01/2011 - "Two recent studies from Iran and Brazil suggest that povidone-iodine may not be effective for prevention of chlamydial or gonococcal ophthalmia. " 01/01/2005 - "Compared with these agents, a 2.5% povidone-iodine ophthalmic solution has been found to have greater efficacy for the prevention of ON generally, and chlamydial ophthalmia specifically. " 10/01/2015 - "The purpose of this study was to investigate the pharmacokinetics and safety of intravitreal povidone-iodine (PVI) and its efficacy against experimental Staphylococcus epidermidis endophthalmitis. "

Related Drugs and Biologics

1.	Povidone-Iodine (Betadine)
2.	Chlorhexidine
3.	chlorhexidine gluconate (Dyna-Hex)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Local Anti-Infective Agents (Antiseptics)
6.	Iodine
7.	Dimethyl Sulfoxide (DMSO)
8.	Hydrogel
9.	Sodium Hypochlorite (Clorox)
10.	Gentamicins (Gentamicin)

Related Therapies and Procedures

1.	Catheters
2.	Drug Therapy (Chemotherapy)
3.	Pessaries
4.	Cataract Extraction
5.	Transplants (Transplant)