Retinoic Acid Receptor gamma

A retinoic acid receptor that regulates transcriptional activity by heterodimerizing with nuclear RETINOID X RECEPTORS.

Also Known As:

RAR gamma; RAR gamma1; RAR gamma2; RAR gamma3

Networked: 105 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Retinoic Acid Receptors: 1114
      - Retinoic Acid Receptor gamma: 105
        human RARG protein
        mouse Rarg protein
        zebrafish Rargb protein
  - Cytoplasmic and Nuclear Receptors: 3987
    - Retinoic Acid Receptors: 1114
      - Retinoic Acid Receptor gamma: 105
        human RARG protein
        mouse Rarg protein
        zebrafish Rargb protein

Experts

1.	Dreno, Brigitte: 2 articles (07/2022 - 01/2021)
2.	Abzug, Joshua M: 2 articles (04/2020 - 01/2020)
3.	Cellini, Ashley: 2 articles (04/2020 - 01/2020)
4.	Enomoto-Iwamoto, Motomi: 2 articles (04/2020 - 01/2020)
5.	Iwamoto, Masahiro: 2 articles (04/2020 - 01/2020)
6.	Tian, Hongying: 2 articles (04/2020 - 01/2020)
7.	El-Naggar, Adel K: 2 articles (01/2018 - 01/2006)
8.	Zeng, Jin-Zhang: 2 articles (01/2017 - 03/2010)
9.	Zhang, Xiao-Kun: 2 articles (01/2017 - 03/2010)
10.	Hind, Matthew: 2 articles (05/2011 - 11/2009)

Related Diseases

1.	Vitamin A Deficiency 06/01/1997 - "RAR beta/RAR gamma double mutants show major ocular defects including a shortening of the ventral retina and pre-natal retinal dysplasia, both of which represent the only abnormalities of the fetal vitamin-A deficiency (VAD) syndrome not previously detected in RAR beta2/RAR gamma compound mutants. " 11/01/1992 - "Vitamin A deficiency also resulted in reduced expression of tissue transglutaminase in the bladder, lungs and trachea, which paralleled the effects observed for RAR beta and RAR gamma. " 01/01/1997 - "Mice deficient in RAR alpha or RAR gamma (i.e., all alpha or gamma isoforms disrupted) show aspects of the post-natal vitamin A deficiency (VAD) syndrome which can be cured or prevented by RA, including post-natal lethality, poor weight gain and male sterility. " 09/15/1992 - "Although vitamin A deficiency caused no significant changes in the levels of RAR alpha and RAR gamma mRNAs, the level of RAR beta transcripts was greatly decreased in various tissues of vitamin A-deficient rats, but was restored rapidly to a normal level after administration of retinoic acid. "
2.	Male Infertility (Male Sterility) 05/21/1993 - "RAR gamma 2 mutants appeared normal, whereas RAR gamma mutants exhibited growth deficiency, early lethality, and male sterility due to squamous metaplasia of the seminal vesicles and prostate. " 01/01/1997 - "Mice deficient in RAR alpha or RAR gamma (i.e., all alpha or gamma isoforms disrupted) show aspects of the post-natal vitamin A deficiency (VAD) syndrome which can be cured or prevented by RA, including post-natal lethality, poor weight gain and male sterility. "
3.	Weight Gain 01/01/1997 - "Mice deficient in RAR alpha or RAR gamma (i.e., all alpha or gamma isoforms disrupted) show aspects of the post-natal vitamin A deficiency (VAD) syndrome which can be cured or prevented by RA, including post-natal lethality, poor weight gain and male sterility. "
4.	Lung Diseases (Lung Disease) 11/01/2009 - "The development of a selective retinoic acid receptor gamma agonist for the treatment of emphysema represents the first of a new class of small-molecule regenerative therapies that may prove useful for the treatment of destructive or age-related lung disease."
5.	Emphysema 11/01/2009 - "Based on this hypothesis, Roche Holding AG is developing palovarotene (R-667, RO-3300074), a selective retinoic acid receptor gamma agonist for the treatment of emphysema. " 11/01/2009 - "Palovarotene, a novel retinoic acid receptor gamma agonist for the treatment of emphysema." 11/01/2009 - "The development of a selective retinoic acid receptor gamma agonist for the treatment of emphysema represents the first of a new class of small-molecule regenerative therapies that may prove useful for the treatment of destructive or age-related lung disease."

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	retinoic acid receptor beta
3.	Retinoids
4.	Tretinoin (Retinoic Acid)
5.	Retinoid X Receptors (Retinoid X Receptor)
6.	Acids
7.	Doxorubicin (Adriamycin)
8.	Am 580 (Am580)
9.	Messenger RNA (mRNA)
10.	Retinoic Acid Receptors (Retinoic Acid Receptor)

Related Therapies and Procedures

1.	Therapeutics