Genomic Medicine

A medical discipline using genomic information about an individual as part of their clinical care (e.g. for diagnostic or therapeutic decision-making) and the health outcomes and policy implications of that clinical use. (From www.genome.gov/health/Genomics-and-Medicine accessed 12/28/2020)

Also Known As:

Networked: 421 relevant articles (12 outcomes, 41 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Evans, D Gareth: 7 articles (01/2022 - 01/2017)
2.	Williams, Marc S: 6 articles (11/2022 - 05/2012)
3.	Lalloo, Fiona: 6 articles (01/2022 - 12/2017)
4.	Nishio, Kazuto: 6 articles (11/2021 - 09/2018)
5.	Kanai, Masashi: 5 articles (10/2022 - 04/2019)
6.	Wallace, Andrew J: 5 articles (01/2022 - 02/2020)
7.	Woodward, Emma R: 5 articles (01/2022 - 12/2017)
8.	Yoshino, Takayuki: 5 articles (11/2021 - 09/2018)
9.	Komine, Keigo: 5 articles (05/2021 - 04/2019)
10.	Sunami, Kuniko: 5 articles (05/2021 - 09/2018)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2021 - "Cancer genomic medicine is a medical treatment in which a large number of genes are analyzed at once by next generation sequencing(NGS), mainly using cancer tissues, to reveal the genetic alterations in the patient's cancer so that the best treatment can be applied for each patient. " 10/01/2020 - "Advances in cytotoxic chemotherapy, surgical oncology, genomic medicine, targeted small molecule treatment, cancer immunotherapy and biology-driven precision radiation oncology have resulted in significant improvements in outcomes of cancer treatment, with an increasing number of patients achieving long-term disease control or even being potentially cured. " 11/01/2013 - "The advent of genomic medicine and sequencing analysis of entire cancer genomes has rapidly improved our understanding of cancer genomics and has defined pathogenetic lesions initiating and driving cancer phenotypes in a causative manner. " 06/29/2023 - "The invited speakers discussed ongoing collaborative research, regulatory perspectives to improve new drug access in Asia, the status of phase I trials in Asia, the introduction of research activities at the National Cancer Center (NCC) and the implementation of genomic medicine. " 01/01/2023 - "The objectives of this review were to identify and characterize decision impact studies in genomic medicine in cancer care and categorize the types of clinical utility outcomes reported. "
2.	Rare Diseases (Rare Disease) 01/01/2023 - "The creation of a dedicated program implementing genomic medicine to improve care in the NICU allows not only for improved access to genomic sequencing for rapid diagnosis, but also advancement of rare disease research and precision therapeutics. " 08/23/2023 - "Genomic medicine is revolutionizing the diagnosis of rare diseases, but the implementation has not benefited underrepresented populations to the same degree. " 01/01/2021 - "To fill this need, we present GeneBreaker, a tool that creates synthetic rare disease cases with utility for benchmarking variant calling approaches, testing the efficacy of variant prioritization, and as an educational mechanism for training diagnostic practitioners in the expanding field of genomic medicine. " 11/22/2021 - "Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol [version 1; peer review: 2 approved, 2 approved with reservations]." 01/01/2021 - "Mixed-methods evaluation of the NHS Genomic Medicine Service for paediatric rare diseases: study protocol."
3.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "Breast cancer screening, diagnosis, and treatment have benefited greatly from genomic medicine in high-income settings. " 02/07/2020 - "397 women with breast cancer diagnosed <36 years of age were obtained from three sources: (i) a population-based study of 283 women diagnosed sequentially from 1980-1997 in North-West England, (ii) referrals to the Genomic Medicine Department at St Mary's Hospital from 1990-2018, and (iii) individuals from (i) and the Family History Clinic at Wythenshawe Hospital South Manchester who tested negative for pathogenic variants (PV) in all three genes. " 01/01/2020 - "The recent introduction of genomic medicine and emphasis on optimizing breast cancer risk reduction mortalities has provided opportunities for pathologists to partner with clinicians in advancing the diagnosis and management of breast cancer patients. " 01/01/2020 - "Pioneering Informed Consent for Return of Research Results to Breast Cancer Patients Facing Barriers to Implementation of Genomic Medicine: The Kenyan BRCA1/2 Testing Experience Using Whole Exome Sequencing." 03/01/2017 - "Mutation screening of the breast cancer genes BRCA1 and BRCA2 identifies a large fraction of variants of uncertain clinical significance (VUS) whose functional and clinical interpretations pose a challenge for genomic medicine. "
4.	Myotonic Dystrophy (Dystrophia Myotonica) 11/20/2019 - "Ongoing study of myotonic dystrophy type 1-associated hypogammaglobulinemia using contemporary tools of genomic medicine may help to further delineate the pathogenesis of this entity."
5.	Agammaglobulinemia (Hypogammaglobulinemia) 11/20/2019 - "Ongoing study of myotonic dystrophy type 1-associated hypogammaglobulinemia using contemporary tools of genomic medicine may help to further delineate the pathogenesis of this entity."

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Cell-Free Nucleic Acids
3.	DNA (Deoxyribonucleic Acid)
4.	MicroRNAs (MicroRNA)
5.	Generic Drugs
6.	Dystrophin
7.	Tyrosine (L-Tyrosine)
8.	Antipsychotic Agents (Antipsychotics)
9.	Proteins (Proteins, Gene)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Precision Medicine
5.	Radiotherapy