Kimura Disease

A chronic inflammatory disease characterized by benign enlargement of cervical LYMPH NODE and SALIVARY GLANDS with increased levels of IMMUNOGLOBULIN E. Unlike ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA it involves eosinophil infiltrates in lymph node and salivary glands and mostly found in Asian males.

Also Known As:

Eosinophilic Granuloma of Soft Tissue; Eosinophilic Hyperplastic Lymphogranuloma; Eosinophilic Lymphofollicular Granuloma; Eosinophilic Lymphofolliculosis; Disease, Kimura; Disease, Kimura's; Eosinophilic Hyperplastic Lymphogranulomas; Eosinophilic Lymphofollicular Granulomas; Eosinophilic Lymphofolliculoses; Granuloma, Eosinophilic Lymphofollicular; Hyperplastic Lymphogranuloma, Eosinophilic; Kimura's Diseases; Kimuras Disease; Lymphofollicular Granuloma, Eosinophilic; Lymphofolliculosis, Eosinophilic; Lymphogranuloma, Eosinophilic Hyperplastic; Kimura's Disease

Networked: 211 relevant articles (19 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Nephrotic Syndrome (Syndrome, Nephrotic)
2.	Lymphadenopathy
3.	Atopic Dermatitis (Atopic Eczema)
4.	Ulcerative Colitis
5.	Disease Progression

Experts

1.	Nonaka, Manabu: 3 articles (10/2017 - 08/2014)
2.	Sakitani, Eri: 3 articles (10/2017 - 08/2014)
3.	Yoshihara, Toshio: 3 articles (10/2017 - 08/2014)
4.	Kaneko, Naoki: 2 articles (01/2022 - 12/2019)
5.	Kiyoshima, Tamotsu: 2 articles (01/2022 - 12/2019)
6.	Maehara, Takashi: 2 articles (01/2022 - 12/2019)
7.	Munemura, Ryusuke: 2 articles (01/2022 - 12/2019)
8.	Murakami, Yuka: 2 articles (01/2022 - 12/2019)
9.	Nakamura, Seiji: 2 articles (01/2022 - 12/2019)
10.	Sato, Yasuharu: 2 articles (01/2022 - 12/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Kimura Disease:

1.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2002 - "In this case, treatment with cyclosporine dramatically improved the lesions of both Kimura's disease and lichen amyloidosus. " 03/01/2017 - "Low-dose cyclosporine for rapid remission and maintenance in recurrent Kimura's disease." 01/01/2005 - "Recently, cyclosporine has been reported to be effective in the treatment of Kimura's disease. " 01/01/2020 - "Remission of Kimura Disease With Carotid Hypervascularization After Cyclosporine Treatment." 10/01/2011 - "We support the use of cyclosporine for maintaining remission in paediatric patients with Kimura's disease."
2.	Tacrolimus (Prograf)FDA LinkGeneric 02/01/2014 - "We report preliminary results of an ongoing study that assesses the efficacy of tacrolimus on Kimura's disease (KD). " 02/01/2014 - "Tacrolimus on Kimura's disease: a case report." 01/01/2019 - "Minimal change disease and Kimura's disease responding to tacrolimus therapy."
3.	Inosine Triphosphate (ITP)IBA 01/01/2021 - "The platelet count fluctuated repeatedly with the relapse of Kimura's disease and a diagnosis of a combination of Kimura's disease and ITP was made through lymph node regeneration and bone marrow examination. " 01/01/2021 - "In this study, we report a rare case of immune thrombocytopenic purpura (ITP) associated with the worsening of Kimura's disease. " 01/01/2021 - "Since then, the dose of prednisolone has been gradually reduced, and the disease status of both Kimura's disease and ITP has been controlled." 01/01/2021 - "Treatment with prednisolone (1 mg/kg/day) was initiated for Kimura's disease and ITP, and lymphadenopathy and platelet count improved promptly. "
4.	dupilumabIBA 11/01/2023 - "Clinical effects of dupilumab: A novel treatment for Kimura disease." 11/24/2023 - "Diagnostic challenges and updated therapeutic strategies of Kimura's disease: A case report successfully treated by dupilumab and review." 01/01/2022 - "Kimura Disease of the Thigh Treated With Surgical Excision and Dupilumab." 01/01/2022 - "Dupilumab for recalcitrant Kimura disease." 01/01/2022 - "Treatment of Kimura Disease With Dupilumab."
5.	Prednisolone (Predate)FDA LinkGeneric 06/01/2021 - "The patient was diagnosed with Kimura disease (KD) and treated with oral prednisolone, tapering from 10 mg/day for approximately 8 months. " 04/01/2007 - "Pathological evaluation following subtotal excision of the mass confirmed Kimura's disease and the patient was given prednisolone p.o. " 05/01/1993 - "The patient was diagnosed with Kimura's disease by neck lymph node biopsy, then received simple excision of mass and oral prednisolone therapy. " 01/01/2021 - "Since then, the dose of prednisolone has been gradually reduced, and the disease status of both Kimura's disease and ITP has been controlled." 10/01/2001 - "Cytokine levels and the effect of prednisolone on Kimura's disease: report of a case."
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2020 - "Treatment of Kimura's disease with oral corticosteroid and methotrexate." 06/01/1999 - "[A case of Kimura disease treated with interferon and general corticoid therapy]." 06/01/2015 - "The patient was treated with corticosteroid and cyclosporine A, with a significant improvement of the symptoms and signs of Kimura disease and no recurrence of any thromboembolism. "
7.	mepolizumabIBA 07/01/2021 - "Mepolizumab-responsive Kimura disease." 01/18/2021 - "Based on our English-language MEDLINE literature search, to our knowledge this is the first case report describing treatment of Kimura's disease with mepolizumab." 09/01/2019 - "Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report." 01/18/2021 - "Eosinophilic chronic rhinosinusitis and concurrent Kimura's disease treated with mepolizumab."
8.	GlucocorticoidsIBA 04/02/2022 - "Our case provides a novel insight that Kimura's disease should be involved in the differential diagnosis of inflammatory lesion mass of orbit and also supports systemic regular glucocorticoid as a valuable therapy of such condition, but close follow-up and long-term observation are crucial." 06/01/2011 - "Effective treatment of Kimura's disease with leflunomide in combination with glucocorticoids."
9.	Leflunomide (Arava)FDA LinkGeneric 06/01/2011 - "Effective treatment of Kimura's disease with leflunomide in combination with glucocorticoids." 01/01/2014 - "Successful treatment of Kimura's disease with leflunomide and methylprednisolone: a case report."
10.	tofacitinibIBA 10/01/2021 - "Efficacy of tofacitinib in Kimura's disease in a patient with concomitant atopic dermatitis."

Therapies and Procedures

1.	Radiotherapy 01/01/2014 - "Radiotherapy is an effective treatment for Kimura's disease of the orbit. " 02/01/1998 - "Radiotherapy is an effective treatment for Kimura's disease. " 04/01/1980 - "[Three cases of Kimura's disease cured by radiation therapy (author's transl)]." 08/07/2021 - "We suggest that radiotherapy should be one of the treatments of choice for Kimura's disease both in primary or recurrence setting." 08/07/2021 - "A retrospective review was performed for all Kimura's disease patients treated with radiotherapy at our center between 2002 and 2017. "
2.	Therapeutics 01/01/1996 - "Based on our experience and treatments reported in the literature, we conclude that a combination therapy consisting mainly of surgery is the most effective treatment of Kimura's disease." 01/01/2023 - "Base on the study, it is found that Kimura disease is rare and may have the atypical symptoms in pediatric patients, combination therapy is recommended to reduce recurrence, and long-term follow-up should be performed." 03/01/2017 - "The objective of this study was to investigate the clinical features of Kimura's disease in the head and neck region and to compare the local recurrence rate between three therapies used for the treatment of this disease. " 01/01/1990 - "The authors review literature on the clinical picture and possible pathogenesis of Kimura's disease, as well as on therapy of the condition. " 01/01/1987 - "[Therapy of Kimura disease]."
3.	Kidney Transplantation 01/01/1996 - "After kidney transplantation, the patient experienced a remission of both the Kimura's disease and the nephrotic syndrome in the native kidneys, leading to the resumption of renal function by the native kidneys in spite of severe transplant glomerulopathy. " 05/26/2023 - "A 26-year-old Syrian adult, has suffered from focal segmental glomerulosclerosis for 10 years with no history of renal transplantation, complained of swellings in his preauricular area which was diagnosed as Kimura disease. " 03/01/1998 - "Recurrence of focal segmental glomerulosclerosis associated with Kimura's disease after kidney transplantation."
4.	Photochemotherapy (Photodynamic Therapy) 03/01/2012 - "Treatment of Kimura disease with photodynamic therapy: a case study." 03/01/2012 - "Photodynamic therapy was very effective in controlling disease progression in this patient who suffers from Kimura disease." 03/01/2012 - "We report on the application of photodynamic therapy (PDT) in the management of Kimura disease. "
5.	Renal Dialysis (Hemodialysis) 10/01/2012 - "Kimura disease is reported sparsely in patients on maintenance hemodialysis. " 10/01/2012 - "Epitrochlear mass in a patient on maintenance hemodialysis--Kimura disease." 06/01/2005 - "We report the first observed case of Kimura's disease occurring during hemodialysis, involving the thoracic and abdominal lymph nodes, which spontaneously resolved nearly completely after two months. " 06/01/2005 - "Kimura's disease involving thoracic and abdominal lymph nodes in a hemodialysis patient." 01/01/2001 - "To our knowledge, our patient is the first reported case of Kimura's disease occurring in chronic hemodialysis patients. "