Sennosides (Senokot)

Medications derived from SENNA EXTRACT that are used to treat CONSTIPATION.

Also Known As:

Senokot; Pursennid; Senna Glycoside; Sennoside; Sennoside A Calcium; Sennoside A Calcium and Sennoside B Calcium; Sennoside A&B; Sennoside A&B, Calcium Salt; Sennoside A+B Calcium; Sennoside A, Calcium Salt; Sennoside A, Calcium Salt (1:1); Sennoside B Calcium; Sennoside B, Calcium Salt; Sennosides A and B; Sennosides A and B Acids

Networked: 91 relevant articles (11 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Le, Jiamei: 3 articles (01/2020 - 01/2018)
2.	Sun, Yongning: 3 articles (01/2020 - 01/2018)
3.	Lee, Ji Hyun: 2 articles (08/2022 - 01/2014)
4.	Huang, Cheng: 2 articles (12/2021 - 11/2020)
5.	Li, Jun: 2 articles (12/2021 - 11/2020)
6.	Ma, Taotao: 2 articles (12/2021 - 11/2020)
7.	Xu, Songbing: 2 articles (12/2021 - 11/2020)
8.	Zhao, Huizi: 2 articles (12/2021 - 11/2020)
9.	Zhu, Hong: 2 articles (12/2021 - 11/2020)
10.	Cheng, Ying: 2 articles (07/2021 - 10/2018)

Related Diseases

1.	Constipation 03/01/1962 - "This study investigates the incidence of constipation in two representative mental institutions, and the effect, in one of the hospitals, of restricting the use of laxatives to only one drug, namely, standardized senna (Senokot). " 07/15/2023 - "Sennoside A should be used in regular dosages for less than one week, as it provides significant relief of constipation and exhibits no colonic damage within 7 days of administration. " 07/15/2023 - "Based on a mouse constipation model, 2.6 mg/kg sennoside A was administered orally for 1, 3, 7, 14 and 21 days, respectively. " 05/01/2021 - "Additional research is needed to adequately assess the effect of the Senokot "cocktail" on postoperative constipation in the rehabilitation population." 05/01/2021 - "The Effectiveness of a Senokot Cocktail for Postoperative Constipation."
2.	Diarrhea 05/05/2018 - "Sennoside (30-100 mg/kg, p.o.) also increased fecal wet weight; however, it significantly increased fluid content with diarrhea. " 01/01/2011 - "Sennoside A is well known to induce diarrhea. " 01/01/2011 - "Cassia angustifolia Vahl (senna) is a natural product that contains sennosides, which are active components that affect the intestinal tract and induce diarrhea. " 01/01/1988 - "Oral administration of sennosides (20-30 mg/kg) to fasted dogs has been shown to induce a strong and long-lasting inhibition of myoelectric colon activity which was evident after a delay of 6-10 h corresponding to oro-cecal transit and colonic metabolism and was accompanied by abundant diarrhea. " 07/01/2000 - "In sennoside-induced diarrhea, loperamide and CP improved stool consistency and this was accompanied by reduced fecal moisture and frequency of diarrhea. "
3.	Opioid-Induced Constipation 04/01/2020 - "Our study found weak evidence that PEG is superior to sennosides with respect to overall effectiveness in cancer patients with opioid-induced constipation." 04/01/2020 - "Outpatients ≥ 18 years old with cancer, at risk of or already experiencing opioid-induced constipation, were randomly assigned to begin a standard bowel protocol of escalating doses of sennosides or PEG, plus a dummy preparation. " 04/01/2020 - "PEG vs. sennosides for opioid-induced constipation in cancer care." 11/24/2023 - "Several studies on opioid induced constipation (OIC) concluded that docusate sodium vs either placebo or in combination with sennosides provided no benefit. " 04/01/2020 - "This randomized double-blind, double-dummy, 2-treatment, 2-period crossover study aimed to compare the efficacy and tolerability of polyethylene glycol (PEG) and sennosides in ambulatory cancer patients with opioid-induced constipation. "
4.	Neoplasms (Cancer) 01/01/2000 - "These effects may reflect the mechanism for the suggested cancer-promoting effect of chronic sennoside use." 04/01/2020 - "Our study found weak evidence that PEG is superior to sennosides with respect to overall effectiveness in cancer patients with opioid-induced constipation." 04/01/2020 - "Outpatients ≥ 18 years old with cancer, at risk of or already experiencing opioid-induced constipation, were randomly assigned to begin a standard bowel protocol of escalating doses of sennosides or PEG, plus a dummy preparation. " 04/01/2020 - "PEG vs. sennosides for opioid-induced constipation in cancer care." 01/01/2017 - "Collaboratively, these results demonstrate that sennoside A is a novel inhibitor of SSHs and suggest that it may be valuable in the development of pharmaceutical drugs for treating cancer metastasis."
5.	Body Weight (Weight, Body) 01/01/1988 - "In a 6-month study with rats, sennosides were tolerated without specific toxic effects in doses up to 100 mg/kg. Effects on food consumption, body weight gain and some biochemical parameters as well as slight renal lesions can be interpreted as secondary effects following chronic diarrhoea. " 01/01/1988 - "Intraduodenal application of sennosides (2 mg/kg body weight) accelerated the half colon transit time from 60 +/- 10 (SEM) to 43 +/- 7 min. At the same time the ratio of long-spike bursts to short-spike bursts was changed from 0.22 to 10.1. " 01/01/1988 - "After gastric administration of daily 100 mg sennosides/kg body weight, no morphological differences could be found between the colon of treated rats and the controls. " 11/01/2004 - "She had been taking many laxatives (bisacodyl, sennoside, aloe extract) for 12 years to control her body weight. " 10/01/1993 - "Colonic motility of rats chronically pretreated with either 10 or 40 mg sennosides/kg body weight daily, 30 mg sennosides/kg twice a week or 500 mg danthron/kg daily for 6 months has been evaluated in ex vivo preparations. "

Related Drugs and Biologics

1.	Dioctyl Sulfosuccinic Acid (DOSS)
2.	Calcium
3.	Sulfur
4.	Charcoal (Charbon)
5.	peppermint oil
6.	Loperamide (Imodium)
7.	Blood Glucose (Blood Sugar)
8.	mitemcinal
9.	Iodine-131
10.	Sennosides (Senokot)

Related Therapies and Procedures

1.	Massage (Zone Therapy)
2.	Peritoneal Dialysis
3.	Oral Administration
4.	Catheters
5.	Pleurodesis