Sphingosine-1-Phosphate Receptors

A subfamily of lysophospholipid receptors with specificity for sphingosine-1-phosphate (e.g., FINGOLIMOD), sphinganine 1-phosphate, 4-hydroxysphinganine 1-phosphate.

Also Known As:

AGR16 Protein; EDG5 Protein; Edg Receptors; Edg-5 Receptor; G-Protein Coupled Receptor H218; H218 Protein; Nrg-1 Receptor; Receptor, Sphingosine-1-Phosphate; S1P Receptor; S1P1 Receptor; S1P2 Receptor; S1P3 Receptor; S1P4 Receptor; S1P5 Receptor; Sphingosine 1-Phosphate Receptor; Sphingosine-1-Phosphate Receptor; Edg 5 Receptor; G Protein Coupled Receptor H218; Nrg 1 Receptor; Sphingosine 1 Phosphate Receptor; Sphingosine 1 Phosphate Receptor 1; Sphingosine 1 Phosphate Receptor 2; Sphingosine 1 Phosphate Receptor 3; Sphingosine 1 Phosphate Receptor 4; Sphingosine 1 Phosphate Receptor 5; Sphingosine 1 Phosphate Receptors; Sphingosine-1-Phosphate Receptor 1; Sphingosine-1-Phosphate Receptor 2; Sphingosine-1-Phosphate Receptor 3; Sphingosine-1-Phosphate Receptor 4; Sphingosine-1-Phosphate Receptor 5

Networked: 1001 relevant articles (67 outcomes, 120 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chun, Jerold: 27 articles (01/2022 - 04/2004)
2.	Hla, Timothy: 23 articles (01/2022 - 04/2004)
3.	Rosen, Hugh: 23 articles (01/2017 - 04/2004)
4.	Proia, Richard L: 13 articles (01/2021 - 04/2004)
5.	Spiegel, Sarah: 10 articles (11/2020 - 06/2005)
6.	Chiba, Kenji: 10 articles (10/2020 - 12/2005)
7.	Brinkmann, Volker: 10 articles (01/2016 - 12/2003)
8.	Salvemini, Daniela: 9 articles (11/2022 - 03/2011)
9.	Cohen, Jeffrey A: 9 articles (10/2021 - 07/2015)
10.	Lynch, Kevin R: 9 articles (01/2020 - 01/2007)

Related Diseases

1.	Multiple Sclerosis 10/01/2017 - "Short-term data for selective sphingosine-1-phosphate receptor modulators support their potential effectiveness in multiple sclerosis, and improved side-effect profiles may widen patient access to this drug class. " 01/01/2020 - "Central Modulation of Selective Sphingosine-1-Phosphate Receptor 1 Ameliorates Experimental Multiple Sclerosis." 01/01/2021 - "Risk for Cardiovascular Adverse Events Associated With Sphingosine-1-Phosphate Receptor Modulators in Patients With Multiple Sclerosis: Insights From a Pooled Analysis of 15 Randomised Controlled Trials." 04/01/2009 - "Research on LP biology has contributed to the development of a first-generation S1P receptor modulator that has entered phase III clinical trials for the treatment of multiple sclerosis. " 03/01/2023 - "An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis."
2.	Autoimmune Diseases (Autoimmune Disease) 02/01/2012 - "The therapeutic value of modulating S1P metabolism and S1P receptor function is currently tested in clinical trials and holds great promise for treatment of different autoimmune diseases. " 01/01/2021 - "Sphingosine-1-phosphate receptor 1 (S1P1) plays an important role in autoimmune disease. " 12/01/2017 - "S1P1 receptor modulation may thus offer potential to treat various autoimmune diseases. " 01/01/2016 - "Because of the ability of S1P1 receptor agonists to suppress lymphocyte egress, they have great potential as therapeutic agents in a variety of autoimmune diseases. " 05/24/2013 - "Synthetic sphingosine 1-phosphate receptor 1 modulators constitute a new class of drugs for the treatment of autoimmune diseases. "
3.	Stroke (Strokes) 01/01/2021 - "Both clinical pilot and experimental stroke studies demonstrate that sphingosine-1-phosphate receptor (S1PR) modulation improves stroke outcome; however, specific mechanisms associated with a beneficial outcome at the level of the cerebrovasculature have not been clearly elucidated. " 01/01/2022 - "In this review, we outline S1P metabolism and S1P receptors, discuss the mechanisms of action of S1P receptor modulators in lymphocyte migration and their direct action on cells of the central nervous system, and provide a concise summary of the efficacy of S1P receptor modulators in animal studies and clinical trials on treatments for stroke." 01/01/2020 - "Data from experimental stroke models and clinical trials suggest that selective sphingosine-1-phosphate receptor type 1 (S1PR1) modulation improves endothelial health and function and, as a result, contributes to improved neurological outcome post ischemic injury. " 06/01/2023 - "Modulators of the sphingosine-1-phosphate receptor (S1PR) have been proposed as a promising strategy for treating stroke. " 04/21/2023 - "Sphingosine-1-phosphate receptor 2 (S1PR2), a major regulator of the CNS and immune systems, is injurious in adult stroke. "
4.	Ischemia 02/01/2007 - "Likewise, recovery of blood flow was dramatically reduced after induction of hindlimb ischemia in mice deficient for the S1P receptor 3 (S1P3). " 01/01/2022 - "We found a significant reduction of S1pr2 (sphingosine 1-phosphate receptor 2) in endothelial cells after hindlimb ischemia (HLI). " 12/01/2016 - "Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice." 01/01/2018 - "In this study, we found that sphingosine-1-phosphate receptor (S1PR)2 expressed in pericytes was significantly up-regulated after ischemia in vivo and in vitro. " 01/01/2017 - "Inhibition of Sphingosine-1-phosphate receptors in ischemia reperfusion injured autoimmunity-prone mice."
5.	Neoplasms (Cancer) 01/01/2023 - "Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells against solid tumor." 01/01/2021 - "A Novel Radioimmune 99mTc-Labeled Tracer for Imaging Sphingosine 1-Phosphate Receptor 1 in Tumor Xenografts: An In Vitro and In Vivo Study." 01/01/2023 - "A growing body of evidence indicated that sphingosine-1-phosphate receptor 2 (S1PR2) plays essential roles in the occurrence and development about several human cancers. " 09/03/2021 - "Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation." 11/23/2020 - "Sphingosine-1-phosphate receptor 2 (S1PR2) mediates pleiotropic functions encompassing cell proliferation, survival, and migration, which become collectively de-regulated in cancer. "

Related Drugs and Biologics

1.	Fingolimod Hydrochloride (FTY720)
2.	sphingosine 1-phosphate (sphingosine-1-phosphate)
3.	ozanimod
4.	Enzymes
5.	Interferons
6.	Phosphates (Orthophosphate)
7.	ponesimod
8.	sphingosine kinase
9.	ceralifimod
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Therapeutics
4.	Kidney Transplantation
5.	Transplantation