Lysophospholipid receptors in vertebrate development, physiology, and pathology.

Abstract

Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune cell trafficking and inflammatory reactions. LP signaling is important in cancer, autoimmunity and inflammatory diseases. Research on LP biology has contributed to the development of a first-generation S1P receptor modulator that has entered phase III clinical trials for the treatment of multiple sclerosis. Further basic research on LP signaling is anticipated to lead to novel therapeutic tools to combat various human diseases.

• Authors: Athanasia Skoura, Timothy Hla
• Journal: Journal of lipid research (J Lipid Res) Vol. 50 Suppl Pg. S293-8 (Apr 2009) ISSN: 0022-2275 [Print] United States
• PMID: 19065000 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Lysophospholipid

Topics

• Animals
• Cardiovascular System (metabolism)
• Disease
• Humans
• Nervous System (metabolism)
• Receptors, Lysophospholipid (immunology, metabolism)
• Reproduction
• Vertebrates (immunology, metabolism)