Protein-Arginine Deiminase Type 4

A histone modification enzyme, which converts both ARGININE and monomethyl-arginine to CITRULLINE. It is one of several protein-arginine deiminase isoenzymes. It is a gene regulator involved in APOPTOSIS and CELL DIFFERENTIATION and a potential therapeutic target for the treatment of a variety of diseases.

Also Known As:

PAD V Enzyme; PADI4 Protein; PADI5 Protein; Peptidyl Arginine Deiminase Type 4; Peptidyl Arginine Deiminase Type IV; Peptidylarginine Deiminase IV; Peptidylarginine Deiminase Type 4; Peptidylarginine Deiminase Type IV; Peptidylarginine Deiminase V; Protein Arginine Deiminase 4; Protein Arginine Deiminase Type 4; Protein Arginine Deiminase Type IV; Protein-Arginine Deiminase Type IV

Networked: 70 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Protein-Arginine Deiminases: 285
      - Protein-Arginine Deiminase Type 4: 70
        human PADI4 protein
        mouse peptidylarginine deiminase 4
        rat peptidylarginine deiminase 4

Experts

1.	Thompson, Paul R: 7 articles (01/2019 - 08/2005)
2.	Darrah, Erika: 5 articles (01/2018 - 07/2008)
3.	Rosen, Antony: 5 articles (01/2018 - 07/2008)
4.	Yamada, Ryo: 4 articles (01/2016 - 11/2003)
5.	Yamamoto, Kazuhiko: 4 articles (01/2016 - 11/2003)
6.	Knuckley, Bryan: 4 articles (01/2008 - 02/2006)
7.	Chang, Xiaotian: 3 articles (01/2019 - 03/2006)
8.	Suzuki, Akari: 3 articles (01/2016 - 11/2003)
9.	Luo, Yuan: 3 articles (01/2008 - 02/2006)
10.	Bhatia, Monica: 3 articles (06/2007 - 08/2005)

Related Diseases

1.	Lung Injury 01/01/2018 - "Decreasing NETs reduced lung injury and improved survival after DNase I treatment or with partial protein arginine deiminase 4 deficiency (PAD4+/-). "
2.	Rheumatoid Arthritis 05/01/2014 - "The present study was undertaken to investigate the association of peptidyl-arginine-deiminase type IV gene (PADI4) single nucleotide polymorphisms (SNPs) with rheumatoid arthritis (RA) susceptibility, and to determine whether there is any impact of PADI4 polymorphisms on RA subsets or phenotypes in a large Chinese Han cohort. " 06/30/2020 - "Peptidyl Arginine Deiminase Type 4 Gene Promoter Hypo-Methylation in Rheumatoid Arthritis." 01/01/2016 - "Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. " 06/01/2015 - "There are controversial reports regarding the role of peptidylarginine deiminase type 4 (PADI4) gene polymorphisms and risk of Rheumatoid arthritis (RA). " 06/01/2015 - "Association between Peptidylarginine Deiminase Type 4 rs1748033 Polymorphism and Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran."
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/05/2023 - "This study evaluated the association between peptidyl arginine deiminase type IV (PADI4) and interleukin 33 (IL-33) with systemic lupus erythematosus (SLE) and juvenile idiopathic arthritis (JIA). " 01/01/2005 - "Several multiple, large-scale, genetic studies on autoimmune-disease-associated SNPs have been reported recently: peptidylarginine deiminase type 4 (PADI4) in rheumatoid arthritis (RA); solute carrier family 22 members 4 and 5 (SLC22A4 and 5) in RA and Crohn's disease (CD); programmed cell death 1 (PDCD1) in systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), and RA; and protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in T1D, RA, and SLE. "
4.	Autoimmune Diseases (Autoimmune Disease) 12/16/2022 - "Both peptidyl arginine deiminase type IV (PADI4) and interleukin 33 (IL-33) are the key molecular involved in immune responses in autoimmune diseases. " 01/01/2005 - "Several multiple, large-scale, genetic studies on autoimmune-disease-associated SNPs have been reported recently: peptidylarginine deiminase type 4 (PADI4) in rheumatoid arthritis (RA); solute carrier family 22 members 4 and 5 (SLC22A4 and 5) in RA and Crohn's disease (CD); programmed cell death 1 (PDCD1) in systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), and RA; and protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in T1D, RA, and SLE. " 08/01/2014 - "A considerable number of confirmed associations with RA and other autoimmune disease susceptibility loci including peptidylarginine deiminase type 4 (PADI4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), signal transducer and activator of transcription (STAT4), cluster of differentiation 244 (CD244) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4), located outside the MHC have been reported recently. "
5.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/01/2005 - "Several multiple, large-scale, genetic studies on autoimmune-disease-associated SNPs have been reported recently: peptidylarginine deiminase type 4 (PADI4) in rheumatoid arthritis (RA); solute carrier family 22 members 4 and 5 (SLC22A4 and 5) in RA and Crohn's disease (CD); programmed cell death 1 (PDCD1) in systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D), and RA; and protein tyrosine phosphatase nonreceptor type 22 (PTPN22) in T1D, RA, and SLE. "

Related Drugs and Biologics

1.	Deoxyribonuclease I (Nickase)
2.	Epitopes
3.	HLA-DRB1 Chains (HLA DRB1)
4.	Interleukin-33
5.	Protein Tyrosine Phosphatases
6.	Autoantibodies
7.	Antibodies
8.	Enzymes
9.	Vimentin
10.	Citrulline

Related Therapies and Procedures

1.	Therapeutics